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Tau pathology as determinant of changes in atrophy and cerebral blood flow: a multi-modal longitudinal imaging study
PurposeTau pathology is associated with concurrent atrophy and decreased cerebral blood flow (CBF) in Alzheimer’s disease (AD), but less is known...
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Correlating tau pathology to brain atrophy using a physics-based Bayesian model
Misfolded tau proteins are a classical hallmark of Alzheimer’s disease. Increasing evidence indicates that tau—and not amyloid—is the main agent in...
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Spatiotemporal characterization of cellular tau pathology in the human locus coeruleus–pericoerulear complex by three-dimensional imaging
Tau pathology of the noradrenergic locus coeruleus (LC) is a hallmark of several age-related neurodegenerative disorders, including Alzheimer’s...
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Native PLGA nanoparticles attenuate Aβ-seed induced tau aggregation under in vitro conditions: potential implication in Alzheimer’s disease pathology
Evidence suggests that beta-amyloid (Aβ)-induced phosphorylation/aggregation of tau protein plays a critical role in the degeneration of neurons and...
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Spinal Cord Injury Causes Prominent Tau Pathology Associated with Brain Post-Injury Sequela
Spinal cord injury (SCI) can result in significant neurological impairment and functional and cognitive deficits. It is well established that SCI...
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FGFR3 drives Aβ-induced tau uptake
The amyloid cascade hypothesis suggests that amyloid beta (Aβ) contributes to initiating subsequent tau pathology in Alzheimer’s disease (AD)....
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Staging tau pathology with tau PET in Alzheimer’s disease: a longitudinal study
A biological research framework to define Alzheimer’ disease with dichotomized biomarker measurement was proposed by National Institute on...
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Inhibition of CK2 mitigates Alzheimer’s tau pathology by preventing NR2B synaptic mislocalization
Alzheimer’s disease (AD) is a neurodegenerative disorder that exhibits pathological changes in both tau and synaptic function. AD patients display...
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Cellular and pathological functions of tau
Tau protein is involved in various cellular processes, including having a canonical role in binding and stabilization of microtubules in neurons....
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Detection of astrocytic tau pathology facilitates recognition of chronic traumatic encephalopathy neuropathologic change
Traumatic brain injury (TBI) is associated with the development of a range of neurodegenerative pathologies, including chronic traumatic...
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Associations among locus coeruleus catecholamines, tau pathology, and memory in aging
The locus coeruleus (LC) is the brain’s major source of the neuromodulator norepinephrine, and is also profoundly vulnerable to the development of...
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Islet amyloid polypeptide cross-seeds tau and drives the neurofibrillary pathology in Alzheimer’s disease
BackgroundThe pathologic accumulation and aggregation of tau is a hallmark of tauopathies including Alzheimer’s disease (AD). However, the molecular...
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Synergistic interaction of high blood pressure and cerebral beta-amyloid on tau pathology
BackgroundHypertension has been associated with Alzheimer’s disease (AD) dementia as well as vascular dementia. However, the underlying...
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Failure of DNA double-strand break repair by tau mediates Alzheimer’s disease pathology in vitro
DNA double-strand break (DSB) is the most severe form of DNA damage and accumulates with age, in which cytoskeletal proteins are polymerized to...
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Mass spectrometric simultaneous quantification of tau species in plasma shows differential associations with amyloid and tau pathologies
Blood phosphorylated tau (p-tau) biomarkers, at differing sites, demonstrate high accuracy to detect Alzheimerʼs disease (AD). However, knowledge on...
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Antisense oligonucleotide-based targeting of Tau-tubulin kinase 1 prevents hippocampal accumulation of phosphorylated tau in PS19 tauopathy mice
Tau tubulin kinase-1 (TTBK1), a neuron-specific tau kinase, is highly expressed in the entorhinal cortex and hippocampal regions, where early tau...
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Increase in wasteosomes (corpora amylacea) in frontotemporal lobar degeneration with specific detection of tau, TDP-43 and FUS pathology
Wasteosomes (or corpora amylacea) are polyglucosan bodies that appear in the human brain with aging and in some neurodegenerative diseases, and have...
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Pathological and neurophysiological outcomes of seeding human-derived tau pathology in the APP-KI NL-G-F and NL-NL mouse models of Alzheimer’s Disease
The two main histopathological hallmarks that characterize Alzheimer’s Disease are the presence of amyloid plaques and neurofibrillary tangles. One...
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Tau seed amplification assay reveals relationship between seeding and pathological forms of tau in Alzheimer’s disease brain
Tau seed amplification assays (SAAs) directly measure the seeding activity of tau and would therefore be ideal biomarkers for clinical trials...
