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Neuronal tau pathology worsens late-phase white matter degeneration after traumatic brain injury in transgenic mice
Traumatic brain injury (TBI) causes diffuse axonal injury which can produce chronic white matter pathology and subsequent post-traumatic...
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Tau Pathology in Neurodegenerative Diseases
Aggregation and cellular accumulation of tau protein is a defining feature of tauopathies, a class of histopathologically and clinically...
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CSF MTBR-tau243 is a specific biomarker of tau tangle pathology in Alzheimer’s disease
Aggregated insoluble tau is one of two defining features of Alzheimer’s disease. Because clinical symptoms are strongly correlated with tau...
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APOEε4 potentiates amyloid β effects on longitudinal tau pathology
The mechanisms by which the apolipoprotein E ε4 ( APOE ε4) allele influences the pathophysiological progression of Alzheimer’s disease (AD) are poorly...
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Predicting Cognitive Decline for Non-Demented Adults with High Burden of Tau Pathology, Independent of Amyloid Status
BackgroundAbnormal tau proteins are independent contributors to cognitive impairment. Nevertheless, not all individuals exposed to high-level tau...
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Genetic forms of tauopathies: inherited causes and implications of Alzheimer’s disease-like TAU pathology in primary and secondary tauopathies
Tauopathies are a heterogeneous group of neurologic diseases characterized by pathological axodendritic distribution, ectopic expression, and/or...
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CSF tau phosphorylation occupancies at T217 and T205 represent improved biomarkers of amyloid and tau pathology in Alzheimer’s disease
Cerebrospinal fluid (CSF) amyloid-β peptide (Aβ)42/Aβ40 and the concentration of tau phosphorylated at site 181 (p-tau181) are well-established...
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Earlier Alzheimer’s disease onset is associated with tau pathology in brain hub regions and facilitated tau spreading
In Alzheimer’s disease (AD), younger symptom onset is associated with accelerated disease progression and tau spreading, yet the mechanisms...
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Granulovacuolar degeneration bodies are independently induced by tau and α-synuclein pathology
BackgroundGranulovacuolar degeneration bodies (GVBs) are intracellular vesicular structures that commonly accompany pathological tau accumulations in...
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Methylene blue accelerates liquid-to-gel transition of tau condensates impacting tau function and pathology
Preventing tau aggregation is a potential therapeutic strategy in Alzheimer’s disease and other tauopathies. Recently, liquid–liquid phase separation...
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Physiological expression of mutated TAU impaired astrocyte activity and exacerbates β-amyloid pathology in 5xFAD mice
BackgroundAlzheimer’s disease (AD) is the leading cause of dementia in the world. The pathology of AD is affiliated with the elevation of both tau...
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Phosphorylated tau in the retina correlates with tau pathology in the brain in Alzheimer’s disease and primary tauopathies
The retina is a potential source of biomarkers for the detection of neurodegenerative diseases. Accumulation of phosphorylated tau (p-tau) in the...
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Cognitive, functional, and neuropsychiatric correlates of regional tau pathology in autopsy-confirmed chronic traumatic encephalopathy
BackgroundChronic traumatic encephalopathy (CTE) is a neurodegenerative disease characterized by hyperphosphorylated tau (p-tau) accumulation. The...
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Direct and Indirect Effects of Filamin A on Tau Pathology in Neuronal Cells
In Alzheimer disease (AD), Tau, an axonal microtubule-associated protein, becomes hyperphosphorylated, detaches from microtubules, accumulates, and...
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Proteasomal Stimulation by MK886 and Its Derivatives Can Rescue Tau-Induced Neurite Pathology
Proteasomal degradation of intrinsically disordered proteins, such as tau, is a critical component of proteostasis in both aging and...
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PTPRS is a novel marker for early Tau pathology and synaptic integrity in Alzheimer’s disease
We examined the role of protein tyrosine phosphatase receptor sigma (PTPRS) in the context of Alzheimer’s disease and synaptic integrity. Publicly...
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Chronic pain causes Tau-mediated hippocampal pathology and memory deficits
Persistent pain has been recently suggested as a risk factor for dementia. Indeed, chronic pain is frequently accompanied by maladaptive brain...
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p-tau Ser356 is associated with Alzheimer’s disease pathology and is lowered in brain slice cultures using the NUAK inhibitor WZ4003
Tau hyperphosphorylation and aggregation is a common feature of many dementia-causing neurodegenerative diseases. Tau can be phosphorylated at up to...
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Plasma N-terminal containing tau fragments (NTA-tau): a biomarker of tau deposition in Alzheimer’s Disease
BackgroundNovel phosphorylated-tau (p-tau) blood biomarkers (e.g., p-tau181, p-tau217 or p-tau231), are highly specific for Alzheimer’s disease (AD),...
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Microglial activation protects against accumulation of tau aggregates in nondemented individuals with underlying Alzheimer’s disease pathology
The role of microglia in tau accumulation is currently unclear but could provide an important insight into the mechanisms underlying Alzheimer’s...
