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Hsc70 promotes anti-tumor immunity by targeting PD-L1 for lysosomal degradation
Immune checkpoint inhibition targeting the PD-1/PD-L1 pathway has become a powerful clinical strategy for treating cancer, but its efficacy is...
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Root microbiota confers rice resistance to aluminium toxicity and phosphorus deficiency in acidic soils
Aluminium (Al) toxicity impedes crop growth in acidic soils and is considered the second largest abiotic stress after drought for crops worldwide....
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Evaluating the Comprehensive Performance of Herbaceous Peonies at low latitudes by the Integration of Long-running Quantitative Observation and Multi-Criteria Decision Making Approach
Enlarging the planting area of economic plants, such as the “Southward Planting of Herbaceous Peony” ( Paeonia lactiflora . Pall), is significant for...
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Multiscale architecture design of 3D printed biodegradable Zn-based porous scaffolds for immunomodulatory osteogenesis
Reconciling the dilemma between rapid degradation and overdose toxicity is challenging in biodegradable materials when shifting from bulk to porous...
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Comprehensive multi-omics analysis reveals WEE1 as a synergistic lethal target with hyperthermia through CDK1 super-activation
Hyperthermic intraperitoneal chemotherapy’s role in ovarian cancer remains controversial, hindered by limited understanding of hyperthermia-induced...
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Guapiaçu virus, a new insect-specific flavivirus isolated from two species of Aedes mosquitoes from Brazil
Classical insect-flaviviruses (cISFVs) and dual host-related insect-specific flavivirus (dISFV) are within the major group of insect-specific...
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Current prevalence of perioperative early venous thromboembolism and risk factors in Chinese adult patients with inguinal hernia (CHAT-1)
Venous thromboembolism (VTE) is an important postoperative complication. We investigated and analyzed the current inguinal hernia treatment methods...
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Overestimation of the effect of climatic warming on spring phenology due to misrepresentation of chilling
Spring warming substantially advances leaf unfolding and flowering time for perennials. Winter warming, however, decreases chilling accumulation...
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Alpine-style nappes thrust over ancient North China continental margin demonstrate large Archean horizontal plate motions
Whether modern-style plate tectonics operated on early Earth is debated due to a paucity of definitive records of large-scale plate convergence,...
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Biological fermentation pilot-scale systems and evaluation for commercial viability towards sustainable biohydrogen production
Featuring high caloric value, clean-burning, and renewability, hydrogen is a fuel believed to be able to change energy structure worldwide....
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Damage accumulation mechanism in PIN diode limiters induced via multiple microwave pulses
Positive-intrinsic-negative (PIN) diodes are widely used as limiters to protect sensitive components from damage in radio frequency (RF) receiver...
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Health assessment of important tributaries of Three Georges Reservoir based on the benthic index of biotic integrity
China’s Three Gorges Reservoir (TGR) is the largest water conservancy project in the world, and plays a significant role in flood control and water...
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Transgenic soybean expressing a thermostable phytase as substitution for feed additive phytase
Phytase is one of the most effective feed additives to increase the availability of phosphorus and minerals by catalyzing the hydrolysis of phytic...
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Stress breaks universal aging behavior in a metallic glass
Numerous disordered materials display a monotonous slowing down in their internal dynamics with age. In the case of metallic glasses, this general...
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Exploring the trade-offs between electric heating policy and carbon mitigation in China
China has enacted a series of policies since 2015 to substitute electricity for in-home combustion for rural residential heating. The Electric...
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Inferring multilayer interactome networks shaping phenotypic plasticity and evolution
Phenotypic plasticity represents a capacity by which the organism changes its phenotypes in response to environmental stimuli. Despite its pivotal...
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Fish species composition, distribution and community structure in the lower reaches of Ganjiang River, Jiangxi, China
The Ganjiang River (length: 823 km; drainage area: 82,809 km 2 ) is the largest river that flows into Poyang Lake and an important tributary of the...
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Metabolite signatures of diverse Camellia sinensis tea populations
The tea plant ( Camellia sinensis ) presents an excellent system to study evolution and diversification of the numerous classes, types and variable...
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Socioeconomic, environmental and lifestyle factors associated with gestational diabetes mellitus: A matched case-control study in Beijing, China
Gestational diabetes mellitus (GDM) is a common health problem during pregnancy and its prevalence is increasing globally, especially in China. The...
