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Brain vasculature accumulates tau and is spatially related to tau tangle pathology in Alzheimer’s disease
Insoluble pathogenic proteins accumulate along blood vessels in conditions of cerebral amyloid angiopathy (CAA), exerting a toxic effect on vascular...
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Tau proteins in blood as biomarkers of Alzheimer’s disease and other proteinopathies
Alzheimer’s disease (AD), the most common age-dependent neurodegenerative disorder, is characterized neuropathologically by extracellular Aβ plaques...
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Tau: a biomarker of Huntington’s disease
Developing effective treatments for patients with Huntington’s disease (HD)—a neurodegenerative disorder characterized by severe cognitive, motor and...
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A Genetic Validation of the Neurodegeneration Biomarkers Tau-A and Tau-C - A Mendelian Randomization Study
BackgroundDisease modifying treatments for dementia are only just surfacing, and their development is still significantly hindered by the lack of...
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Tau seeding and spreading in vivo is supported by both AD-derived fibrillar and oligomeric tau
Insoluble fibrillar tau, the primary constituent of neurofibrillary tangles, has traditionally been thought to be the biologically active, toxic form...
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Toward standardization of tau PET imaging corresponding to various tau PET tracers: a multicenter phantom study
ObjectiveTau positron emission tomography (PET) imaging is a recently developed non-invasive tool that can detect the density and extension of tau...
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Tau suppresses microtubule-regulated pancreatic insulin secretion
Tau protein is implicated in the pathogenesis of Alzheimer’s disease (AD) and other tauopathies, but its physiological function is in debate. Mostly...
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Tau depletion in human neurons mitigates Aβ-driven toxicity
Alzheimer’s disease (AD) is an age-related neurodegenerative condition and the most common type of dementia, characterised by pathological...
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Identification of high-performing antibodies for the reliable detection of Tau proteoforms by Western blotting and immunohistochemistry
Antibodies are essential research tools whose performance directly impacts research conclusions and reproducibility. Owing to its central role in...
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MSUT2 regulates tau spreading via adenosinergic signaling mediated ASAP1 pathway in neurons
Inclusions comprised of microtubule-associated protein tau (tau) are implicated in a group of neurodegenerative diseases, collectively known as...
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Tau-targeting therapies for Alzheimer disease: current status and future directions
Alzheimer disease (AD) is the most common cause of dementia in older individuals. AD is characterized pathologically by amyloid-β (Aβ) plaques and...
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Serum tau protein elevation in migraine: a cross-sectional case–control study
BackgroundMigraine is a disorder associated with neuropeptide release, pain and inflammation. Tau protein has recently been linked to inflammatory...
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Predicting Cognitive Decline for Non-Demented Adults with High Burden of Tau Pathology, Independent of Amyloid Status
BackgroundAbnormal tau proteins are independent contributors to cognitive impairment. Nevertheless, not all individuals exposed to high-level tau...
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Phosphorylated tau in the retina correlates with tau pathology in the brain in Alzheimer’s disease and primary tauopathies
The retina is a potential source of biomarkers for the detection of neurodegenerative diseases. Accumulation of phosphorylated tau (p-tau) in the...
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p-tau Ser356 is associated with Alzheimer’s disease pathology and is lowered in brain slice cultures using the NUAK inhibitor WZ4003
Tau hyperphosphorylation and aggregation is a common feature of many dementia-causing neurodegenerative diseases. Tau can be phosphorylated at up to...
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Loss of TMEM106B exacerbates Tau pathology and neurodegeneration in PS19 mice
TMEM106B , a gene encoding a lysosome membrane protein, is tightly associated with brain aging, hypomyelinating leukodystrophy, and multiple...
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The contribution of β-amyloid, Tau and α-synuclein to blood–brain barrier damage in neurodegenerative disorders
Central nervous system (CNS) accumulation of fibrillary deposits made of Amyloid β (A β ), hyperphosphorylated Tau or α -synuclein ( α -syn), present...
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Longitudinal striatal dopamine transporter binding and cerebrospinal fluid alpha-synuclein, amyloid beta, total tau, and phosphorylated tau in Parkinson’s disease
BackgroundPrevious studies investigated CSF levels of α-synuclein (α-syn), amyloid-β (Aβ1-42), total tau (t-tau), and phosphorylated tau (p-tau) with...
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Friend or foe: role of pathological tau in neuronal death
Neuronal death is one of the most common pathological hallmarks of diverse neurological diseases, which manifest varying degrees of cognitive or...
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Tau reduction attenuates autism-like features in Fmr1 knockout mice
BackgroundFragile X syndrome (FXS) is a leading cause of autism spectrum disorder (ASD) and resulted from a loss of the FMR1 -encoded fragile X...
