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Serum tau protein elevation in migraine: a cross-sectional case–control study
BackgroundMigraine is a disorder associated with neuropeptide release, pain and inflammation. Tau protein has recently been linked to inflammatory...
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Plasma glial fibrillary acidic protein and tau: predictors of neurological outcome after cardiac arrest
BackgroundThe purpose was to evaluate glial fibrillary acidic protein (GFAP) and total-tau in plasma as predictors of poor neurological outcome after...
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Plasma concentrations of glial fibrillary acidic protein, neurofilament light, and tau in Alexander disease
IntroductionAlexander disease (AxD) is a rare leukodystrophy caused by dominant gain-of-function mutations in the gene encoding the astrocyte...
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Brain vasculature accumulates tau and is spatially related to tau tangle pathology in Alzheimer’s disease
Insoluble pathogenic proteins accumulate along blood vessels in conditions of cerebral amyloid angiopathy (CAA), exerting a toxic effect on vascular...
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OPTN attenuates the neurotoxicity of abnormal Tau protein by restoring autophagy
OPTN is an autophagy receptor involved in autophagic degradation. Here we studied the role of OPTN in attenuating the neurotoxicity induced by...
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Serum tau protein and myelin basic protein in pediatric patients with congenital heart defects undergoing cardiac surgery: preliminary assessment as novel neuromarkers of brain injury
IntroductionNeurological impairment is a big concern in the development of patients with congenital heart defects (CHD). A number of neuromarkers...
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Tau suppresses microtubule-regulated pancreatic insulin secretion
Tau protein is implicated in the pathogenesis of Alzheimer’s disease (AD) and other tauopathies, but its physiological function is in debate. Mostly...
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Tau seeding and spreading in vivo is supported by both AD-derived fibrillar and oligomeric tau
Insoluble fibrillar tau, the primary constituent of neurofibrillary tangles, has traditionally been thought to be the biologically active, toxic form...
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Serum Tau-A and Tau-C Levels and Their Association with Cognitive Impairment and Dementia Progression in a Memory Clinic Derived Cohort
BackgroundSerum-measured fragments of Tau cleaved by ADAM-10 (Tau-A) and Caspase-3 (Tau-C) have been found linked to change in cognitive function and...
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MSUT2 regulates tau spreading via adenosinergic signaling mediated ASAP1 pathway in neurons
Inclusions comprised of microtubule-associated protein tau (tau) are implicated in a group of neurodegenerative diseases, collectively known as...
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Tau depletion in human neurons mitigates Aβ-driven toxicity
Alzheimer’s disease (AD) is an age-related neurodegenerative condition and the most common type of dementia, characterised by pathological...
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A Genetic Validation of the Neurodegeneration Biomarkers Tau-A and Tau-C - A Mendelian Randomization Study
BackgroundDisease modifying treatments for dementia are only just surfacing, and their development is still significantly hindered by the lack of...
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Semorinemab Pharmacokinetics and The Effect on Plasma Total Tau Pharmacodynamics in Clinical Studies
BackgroundSemorinemab is a monoclonal antibody that targets the N-terminal domain of the tau protein that is in clinical development for the...
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Identification of high-performing antibodies for the reliable detection of Tau proteoforms by Western blotting and immunohistochemistry
Antibodies are essential research tools whose performance directly impacts research conclusions and reproducibility. Owing to its central role in...
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Tau: a biomarker of Huntington’s disease
Developing effective treatments for patients with Huntington’s disease (HD)—a neurodegenerative disorder characterized by severe cognitive, motor and...
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Loss of TMEM106B exacerbates Tau pathology and neurodegeneration in PS19 mice
TMEM106B , a gene encoding a lysosome membrane protein, is tightly associated with brain aging, hypomyelinating leukodystrophy, and multiple...
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Tau reduction attenuates autism-like features in Fmr1 knockout mice
BackgroundFragile X syndrome (FXS) is a leading cause of autism spectrum disorder (ASD) and resulted from a loss of the FMR1 -encoded fragile X...
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Immunotherapies Targeting Amyloid and Tau Protein in Alzheimer’s Disease: Should We Move Away from Diseases and Focus on Biological Targets? A Systematic Review and Expert Opinion
IntroductionAlzheimer’s disease (AD) is the most common cause of dementia worldwide, making it a major public health issue. Anti-amyloid and anti-tau...
