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Dynamics of serum levels of TNF-α in a longitudinal follow-up study in 98 patients with juvenile idiopathic arthritis treated with anti-TNF-α biological drugs
ObjectiveTo determine the dynamics of serum levels of TNF-α in patients with juvenile idiopathic arthritis (JIA) treated with anti-TNF-α biological...
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The role of the cytokine TNF-α in choroidal neovascularization: a systematic review
TNF-α is a multifunctional cytokine produced by macrophages and T cells. This proinflammatory substance is considered to play a crucial role in the...
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Relationship between plasma TNF-α levels and agitation symptoms in first episode patients with schizophrenia
BackgroundIncreasing evidence suggested that immune abnormalities involved in the pathophysiology of schizophrenia. However, the relationship between...
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Effect of huankuile on colon injury in rats with ulcerative colitis by reducing TNF-α and MMP9
ObjectiveTo explore the mechanism of huankuile (HKL) in colon injury repair in rats with ulcerative colitis (UC).
MethodsFifty SPF Wistar male rats...
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RyR2 Stabilizer Attenuates Cardiac Hypertrophy by Downregulating TNF-α/NF-κB/NLRP3 Signaling Pathway through Inhibiting Calcineurin
The effect of Ryanodine receptor2 (RyR2) and its stabilizer on cardiac hypertrophy is not well known. C57/BL6 mice underwent transverse aortic...
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The relationship between sarcopenia and serum irisin and TNF-α levels in newly diagnosed cancer patients
ObjectiveSarcopenia in patients with cancer makes patients physically weak and adversely affects their compliance with treatment. In this study, we...
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Assessment of TNF-α expression in unstable atherosclerotic plaques, serum IL-6 and TNF-α levels in patients with acute coronary syndrome and rheumatoid arthritis
The role of inflammatory cytokines is well researched in acute coronary syndrome (ACS) and rheumatoid arthritis (RA), but not in the presence of both...
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The involvement of RIPK4 in TNF-α-stimulated IL-6 and IL-8 production by melanoma cells
PurposeThe receptor-interacting protein kinase (RIPK4) has an oncogenic function in melanoma, regulates NF-κB and Wnt/β-catenin pathways, and is...
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TNF-α in the serum and synovial fluid of patients with rheumatoid arthritis: correlation with sonographic parameters: a cross-sectional study
BackgroundRheumatoid arthritis (RA) is a chronic, inflammatory joint condition characterized by overproduction of pro-inflammatory cytokines. We...
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Sex and race differences in urinary Tumor Necrosis Factor-α (TNF-α) levels: Secondary analysis of the DASH-sodium trial
Previous work in mouse models shows that urinary TNF-α levels become elevated when dietary salt (NaCl) intake increases. To examine if this...
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Secoemestrin C Ameliorates Psoriasis-like Skin Inflammation in Mice by Suppressing the TNF-α/NF-κB Signaling Pathway
ObjectiveSecoemestrin C (SC), an epitetrathiodioxopiperazine isolated from Aspergillus nidulans , has been previously reported to have...
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The Acid Sphingomyelinase Inhibitor Amitriptyline Ameliorates TNF-α-Induced Endothelial Dysfunction
PurposeInflammation associated endothelial cell (EC) dysfunction is key to atherosclerotic disease. Recent studies have demonstrated a protective...
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Baicalein alleviates TNF-α-induced apoptosis of human nucleus pulposus cells through PI3K/AKT signaling pathway
BackgroundNucleus pulposus (NP) cell apoptosis contributed to disc degeneration. Baicalein, a natural steroid saponin, has been demonstrated to have...
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The Effect of Thymoquinone on the TNF-α/OTULIN/NF-κB Axis Against Cisplatin-İnduced Testicular Tissue Damage
One of the adverse effects of the antineoplastic drug cisplatin (CS) is damage to testicular tissue. This study aimed to examine the potential...
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Cost-Utility Analysis of TNF-α Inhibitors, B Cell Inhibitors, and JAK Inhibitors Versus csDMARDs for Rheumatoid Arthritis Treatment
IntroductionRheumatoid arthritis (RA) is a progressive and debilitating disease, causing persistent joint pain that limits daily activities requiring...
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TNF-α activates RELA expression via TNFRSF1B to upregulate OPA1 expression and inhibit chondrogenic differentiation of human adipose stem cells
BackgroundTumor necrosis factor-alpha (TNF-α), one of the pro-inflammatory cytokines mediating the local inflammatory process in joints, inhibits...
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TP53 gain-of-function mutations promote osimertinib resistance via TNF-α–NF-κB signaling in EGFR-mutated lung cancer
EGFR tyrosine kinase inhibitors (TKIs) are effective against EGFR -mutated lung cancer, but tumors eventually develop resistance to these drugs....
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Circulating levels of C1q/TNF-α‐related protein 6 (CTRP6) in coronary artery disease and its correlation with inflammatory markers
IntroductionCirculating levels of C1q/TNF-α‐related protein 6 (CTRP6) is an adipokine that is involved in regulation of glucose and lipid metabolism,...
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Low-energy LED red light inhibits the NF-κB pathway and promotes hPDLSCs proliferation and osteogenesis in a TNF-α environment in vitro
There are few studies on the effect of low-energy LED red light on periodontal tissue regeneration in an inflammatory environment. In this study,...
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Inhibition of the type 1 diabetes candidate gene PTPN2 aggravates TNF-α-induced human beta cell dysfunction and death
Aims/hypothesisTNF-α plays a role in pancreatic beta cell loss in type 1 diabetes mellitus. In clinical interventions, TNF-α inhibition preserves...
