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Rescue in vitro maturation using ovarian support cells of human oocytes from conventional stimulation cycles yields oocytes with improved nuclear maturation and transcriptomic resemblance to in vivo matured oocytes
PurposeDetermine if the gene expression profiles of ovarian support cells (OSCs) and cumulus-free oocytes are bidirectionally influenced by...
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Embryo Culture Medium Has No Impact on Mosaicism Rates: a Sibling Oocyte Study
Human embryos cultured in vitro can contain two or more cytogenetically distinct cell lineages known as “chromosomal mosaicism”. Since mosaicism is...
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Is a day 7 blastocyst predictive of the reproductive potential of sibling day 5 and day 6 blastocysts?
PurposeTo explore if a day 7 blastocyst is predictive of the reproductive potential of sibling day 5 or day 6 blastocysts?
MethodsRetrospective...
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Advanced Maternal Age Affects the Cryosusceptibility of Ovulated but not In Vitro Matured Mouse Oocytes
Oocyte cryopreservation is offered to women of various age groups for both health and social reasons. Oocytes derived from either controlled ovarian...
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Effects of different oocyte cytoplasmic granulation patterns on embryo development and euploidy: a sibling oocyte control study
PurposeThis study evaluated the relationship between cytoplasmic granulation patterns and the developmental potential of mature sibling oocytes.
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More blastocysts are produced from fewer oocytes in ICSI compared to IVF – results from a sibling oocytes study and definition of a new key performance indicator
BackgroundWhich fertilization method, between ICSI and IVF in split insemination treatments, has the highest clinical efficiency in producing...
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Does smooth endoplasmic reticulum aggregation in oocytes impact the chromosome aneuploidy of the subsequent embryos? A propensity score matching study
BackgroundThe appearance of smooth endoplasmic reticulum aggregation (SERa) is one of the most common dysmorphic phenotypes of oocytes, however, the...
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Improved maturation competence of ovarian tissue oocytes using a biphasic in vitro maturation system for patients with gynecological malignancy: a study on sibling oocytes
PurposeTo investigate the developmental competence of ovarian tissue oocytes from patients with gynecological tumors using a biphasic in vitro...
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Degenerative Oocytes in the Aspirated Cohort Are Not Due to the Aspirating Needle: a Prospective Randomized Pilot Study with Sibling Oocytes
The aim of this study is to compare two different needles (17G vs. 20-17G variable diameter) used for OPU and to assess whether the different stress...
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Effect of A23187 ionophore treatment on human blastocyst development—a sibling oocyte study
PurposeTo investigate whether treatment with commercially available ready-to-use A23187 ionophore (GM508-CultActive) improves embryo development...
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In vitro maturation (IVM) of human immature oocytes: is it still relevant?
In vitro maturation (IVM) of human immature oocytes has been shown to be a viable option for patients at risk of ovarian hyperstimulation syndrome...
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Successful Live Birth Outcome Following Assisted Activation of Failed Fertilized Oocytes
Here, we report on a rare case of a live birth following assisted oocyte activation of failed fertilized oocytes. A 34-year-old nulliparous woman...
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Influx of zwitterionic buffer after intracytoplasmic sperm injection (ICSI) membrane piercing alters the transcriptome of human oocytes
Purpose/study questionDoes piercing oocyte membranes during ICSI allow the influx of surrounding zwitterionic buffer into human oocytes and result in...
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Potential effects of assisted reproductive technology on telomere length and telomerase activity in human oocytes and early embryos
Telomeres are repetitive DNA sequences at eukaryotic chromosome ends and function in maintaining genome integrity and stability. These unique...
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Cytoplasmic Transfer Improves Human Egg Fertilization and Embryo Quality: an Evaluation of Sibling Oocytes in Women with Low Oocyte Quality
The aim of this study was to evaluate if cytoplasmic transfer can improve fertilization and embryo quality of women with oocytes of low quality....
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Egg donor self-reports of ovarian hyperstimulation syndrome: severity by trigger type, oocytes retrieved, and prior history
PurposeTo evaluate self-reported survey data provided by US oocyte donors on their experiences with ovarian hyperstimulation syndrome and possible...
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Developmental potential of immature human oocytes aspirated after controlled ovarian stimulation
PurposeIntracytoplasmic sperm injection (ICSI) for initially immature oocytes that mature in vitro is controversial and practice varies widely. While...
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Ionophore application for artificial oocyte activation and its potential effect on morphokinetics: a sibling oocyte study
PurposeTo evaluate whether ionophore application at the oocyte stage changes the morphokinetics of the associated embryos in cases of artificial...
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The effect of amorphous calcium carbonate as a culture media supplement on embryonic development of murine sibling embryos
PurposeThe aim of this study was to compare the addition in culture media of stabilized amorphous calcium carbonate (ACC) versus calcium chloride...
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Rapamycin improves the quality and developmental competence of mice oocytes by promoting DNA damage repair during in vitro maturation
BackgroundIncreasing evidence has shown that the mammalian target of rapamycin (mTOR) pathway plays a critical role in oocyte meiosis and embryonic...
