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  1. Sex-specific differences in ICOS+ T helper cell differentiation in systemic lupus erythematosus patients with low disease activity

    Systemic lupus erythematosus (SLE) is a sex biased chronic autoimmune disease affecting predominantly females during reproductive ages. Changes in...

    Lisa Wu, Florian Kälble, ... Andrea Steinborn in Clinical and Experimental Medicine
    Article Open access 01 March 2024
  2. Laparoscopy versus ultrasonography for the evaluation of Müllerian duct remnants in male patients with disorder of sex differentiation

    Background

    The diagnosis of male differences of sex development is a challenging multidisciplinary team task, that requires external genital...

    Mohamed Sayed Abd El-Monsif, Noha Arafa, ... Ahmed M. K. Wishahy in Egyptian Pediatric Association Gazette
    Article Open access 27 May 2024
  3. Genetic control of typical and atypical sex development

    Sex development relies on the sex-specific action of gene networks to differentiate the bipotential gonads of the growing fetus into testis or...

    Alejandra P. Reyes, Nayla Y. León, ... Vincent R. Harley in Nature Reviews Urology
    Article 05 April 2023
  4. Sex Differences in Circulating Biomarkers of Heart Failure

    Purpose of RevSiew

    Evidence is scaling up for sex differences in heart failure; however, clinical relevance of sex-specific differential thresholds...

    Roopa A. Rao, Anju Bhardwaj, ... Eman Hamad in Current Heart Failure Reports
    Article 07 December 2023
  5. X chromosome agents of sexual differentiation

    Understanding sex differences in physiology and disease requires the identification of the molecular agents that cause phenotypic sex differences....

    Arthur P. Arnold in Nature Reviews Endocrinology
    Article 15 June 2022
  6. Sex differences in trajectories of cortical development in autistic children from 2–13 years of age

    Previous studies have reported alterations in cortical thickness in autism. However, few have included enough autistic females to determine if there...

    Derek S. Andrews, Kersten Diers, ... Christine Wu Nordahl in Molecular Psychiatry
    Article Open access 16 May 2024
  7. Marked intestinal trans-differentiation by autoimmune gastritis along with ectopic pancreatic and pulmonary trans-differentiation

    Background

    Autoimmune gastritis (AIG) is a prevalent chronic inflammatory disease with oncogenic potential that causes destruction of parietal cells...

    Chihiro Takeuchi, Junichi Sato, ... Mitsuhiro Fujishiro in Journal of Gastroenterology
    Article Open access 14 November 2023
  8. Sex and survival outcomes in patients with renal cell carcinoma receiving first-line immune-based combinations

    Background

    There is an ongoing debate as to whether sex could be associated with immune checkpoint inhibitor (ICI) benefit. Existing literature data...

    Lorena Incorvaia, Fernando Sabino Marques Monteiro, ... Matteo Santoni in Cancer Immunology, Immunotherapy
    Article Open access 04 June 2024
  9. Sex bias in immune response: it is time to include the sex variable in studies of autoimmune rheumatic diseases

    Healthy females and males differ in their immune cell composition and function and females generally mount stronger immune response than males and...

    Lazaros I. Sakkas, Ian C. Chikanza in Rheumatology International
    Article 16 September 2023
  10. Mechanisms and consequences of sex differences in immune responses

    Biological sex differences refer to differences between males and females caused by the sex chromosome complement (that is, XY or XX), reproductive...

    Shannon E. Dunn, Whitney A. Perry, Sabra L. Klein in Nature Reviews Nephrology
    Article 22 November 2023
  11. Sex matters: acute functional connectivity changes as markers of remission in late-life depression differ by sex

    The efficacy of antidepressant treatment in late-life is modest, a problem magnified by an aging population and increased prevalence of depression....

    James D. Wilson, Andrew R. Gerlach, ... Carmen Andreescu in Molecular Psychiatry
    Article 06 July 2023
  12. Sex-based Differences in Heart Failure Biomarkers

    Purpose of Review

    Differences in HF biomarker levels by sex may be due to hormonal, genetic, and fat distribution differences. Knowledge of these...

    Ainhoa Robles-Mezcua, Nelsa González Aguado, ... José M. García-Pinilla in Current Heart Failure Reports
    Article 20 May 2024
  13. Ovarian endometrioid carcinoma with a sex cord-like pattern: a morphological, immunohistochemical, and molecular analysis

    Sex cord-like endometrioid carcinoma (SCLEC) is an uncommon entity which may constitute a diagnostic challenge. This study aimed to perform a...

    Antonio Travaglino, Damiano Arciuolo, ... Gian Franco Zannoni in Virchows Archiv
    Article Open access 29 February 2024
  14. Sex differences in energy metabolism: natural selection, mechanisms and consequences

    Metabolic homeostasis operates differently in men and women. This sex asymmetry is the result of evolutionary adaptations that enable women to resist...

    Franck Mauvais-Jarvis in Nature Reviews Nephrology
    Article 03 November 2023
  15. Sex hormones and neuromyelitis optica spectrum disorder: a bidirectional Mendelian randomization study

    Background

    Females are considered to have an increased susceptibility to neuromyelitis optica spectrum disorder (NMOSD) than males, especially...

    Yaxian Hu, Fei Zou, Wei Lu in Neurological Sciences
    Article 02 April 2024
  16. Sex and gender in neurodevelopmental conditions

    Health-related conditions often differ qualitatively or quantitatively between individuals of different birth-assigned sexes and gender identities,...

    Sven Bölte, Janina Neufeld, ... Meng-Chuan Lai in Nature Reviews Neurology
    Article 06 February 2023
  17. First trimester identification of fetal sex by ultrasound

    Purpose

    The hypothesis was fetal sex determination by ultrasound at 11–14 weeks’ gestation has sufficient accuracy to be clinically relevant.

    ...
    Emma C. Schaefer, David S. McKenna, Jiri D. Sonek in Archives of Gynecology and Obstetrics
    Article 03 May 2023
  18. Analyses of sex-based clinicopathological differences among patients with gastrointestinal neuroendocrine neoplasms in Europe

    Background

    Previous studies have found variations in cancer types, tumor progression, and disease outcomes between men and women. However, there is...

    Henning Jann, Sarah Krieg, ... Christoph Roderburg in Journal of Cancer Research and Clinical Oncology
    Article Open access 27 March 2023
  19. Sex impacts treatment decisions in multiple sclerosis

    Background

    Individual disease-modifying treatment (DMT) decisions might differ between female and male people with MS (pwMS).

    Objective ...
    Harald Hegen, Klaus Berek, ... Franziska Di Pauli in Journal of Neurology
    Article Open access 05 March 2024
  20. Sex and blood group determination from hair using ATR-FTIR spectroscopy and chemometrics

    Examination of hair with its intact root is commonly used for DNA profiling of the donor. However, its use for gathering other types of information...

    Sweety Sharma, Srishti Gupta, Praveen Kumar Yadav in International Journal of Legal Medicine
    Article 18 November 2023
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