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Electrophysiological signatures of reward learning in the rodent touchscreen-based Probabilistic Reward Task
Blunted reward learning and reward-related activation within the corticostriatal-midbrain circuitry have been implicated in the pathophysiology of...
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Circadian, Reward, and Emotion Systems in Teens prospective longitudinal study: protocol overview of an integrative reward-circadian rhythm model of first onset of bipolar spectrum disorder in adolescence
BackgroundBipolar spectrum disorders (BSDs) are associated with a heightened sensitivity to rewards and elevated reward-related brain function in...
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Des-acyl ghrelin reduces alcohol intake and alcohol-induced reward in rodents
The mechanisms contributing to alcohol use disorder (AUD) are complex and the orexigenic peptide ghrelin, which enhances alcohol reward, is implied...
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Negative schizotypal traits predict the reduction of reward motivation in effort–reward imbalance
The schizotypy construct is useful for studying the effects of environmental stress on development of subclinical negative symptoms. The relationship...
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An Optional Delinked Reward System: Making Pharmaceutical Innovation Work for Everyone
Conflicts over pharmaceutical pricing are driven by the patients’ need for affordable medicines and the producer’s reward for the investments in...
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NAPE-PLD in the ventral tegmental area regulates reward events, feeding and energy homeostasis
The N -acyl phosphatidylethanolamine-specific phospholipase D (NAPE-PLD) catalyzes the production of N -acylethanolamines (NAEs), a family of...
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Prenatal exposure to alcohol and its impact on reward processing and substance use in adulthood
Heavy maternal alcohol drinking during pregnancy has been associated with altered neurodevelopment in the child but the effects of low-dose alcohol...
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Activation of RMTg projections to the VTA reverse cocaine-induced molecular adaptation in the reward system
The rostromedial tegmental nucleus (RMTg) plays a crucial role in regulating reward-related behavior by exerting inhibitory control over the ventral...
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Altered neural anticipation of reward and loss but not receipt in adolescents with obsessive-compulsive disorder
BackgroundObsessive-compulsive disorder (OCD) is characterized by persistent, unwanted thoughts and repetitive actions. Such repetitive thoughts...
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Women with more severe premenstrual syndrome have an enhanced anticipatory reward processing: a magnetoencephalography study
Laboratory studies reveal that young women with premenstrual syndrome (PMS) often exhibit decreased reward processing during the late luteal phase....
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Managers perception of hospital employees’ effort-reward imbalance
ObjectiveHospitals are frequently associated with poor working conditions that can lead to work stress and increase the risk for reduced employee...
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The ion channel TRPA1 is a modulator of the cocaine reward circuit in the nucleus accumbens
Drug addiction therapies commonly fail because continued drug use promotes the release of excessive and pleasurable dopamine levels. Because the...
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Transdiagnostic considerations of the relationship between reward sensitivity and psychopathological symptoms - a cross-lagged panel analysis
BackgroundReward sensitivity constitutes a potential key mechanism regarding the etiology and maintenance of mental disorders, especially depression....
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Global reward processing deficits predict negative symptoms transdiagnostically and transphasically in a severe mental illness-spectrum sample
Reward processing impairments are a key factor associated with negative symptoms in those with severe mental illnesses. However, past findings are...
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An appetite for aggressive behavior? Female rats, too, derive reward from winning aggressive interactions
While aggression is an adaptive behavior mostly triggered by competition for resources, it can also in and of itself be rewarding. Based on the...
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Effort-reward imbalance and common mental disorders among public sector employees of Iran: a cross-sectional analysis
BackgroundThe effort-reward imbalance (ERI) model is a widely used theoretical model to measure stress in the workplace. The objective of this study...
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Early life stress in male mice blunts responsiveness in a translationally-relevant reward task
Early-life stress (ELS) leaves signatures upon the brain that persist throughout the lifespan and increase the risk of psychiatric illnesses...
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Low doses of lysergic acid diethylamide (LSD) increase reward-related brain activity
Renewed interest in classic psychedelics as treatments for psychiatric disorders warrants a deeper understanding of their neural mechanisms. Single,...
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Altered brain activation during reward anticipation in bipolar disorder
Although altered reward sensitivity has been observed in individuals with bipolar disorder (BD), the brain function findings related to reward...
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Rats choose alcohol over social reward in an operant choice procedure
The interaction between social factors and alcohol addiction is complex, with potential for both positive and negative contributions to drug use and...
