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Truncating PICK1 Variant Identified in Azoospermia Affected Mitochondrial Dysfunction in Knockout Mice
ObjectiveThe protein interacting with C kinase 1 ( PICK1 ) plays a critical role in vesicle trafficking, and its deficiency in sperm cells results in...
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Multi-omics study identifies that PICK1 deficiency causes male infertility by inhibiting vesicle trafficking in Sertoli cells
BackgroundInfertility affects approximately 10–15% of reproductive-age men worldwide, and genetic causes play a role in one-third of cases. As a...
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Protein interacting with C-kinase 1 is involved in epithelial-mesenchymal transformation and suppresses progress of gastric cancer
Protein interacting with C-kinase 1 (PICK1) is a 415-aa multidomain scaffold protein encoded by the PICK1 gene. Accumulating evidence suggests that...
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Protein lipidation in health and disease: molecular basis, physiological function and pathological implication
Posttranslational modifications increase the complexity and functional diversity of proteins in response to complex external stimuli and internal...
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Defects in syntabulin-mediated synaptic cargo transport associate with autism-like synaptic dysfunction and social behavioral traits
The formation and maintenance of synapses require long-distance delivery of newly synthesized synaptic proteins from the soma to distal synapses,...
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Unexpected subcellular distribution of a specific isoform of the Coxsackie and adenovirus receptor, CAR-SIV, in human pancreatic beta cells
Aims/hypothesisThe Coxsackie and adenovirus receptor (CAR) is a transmembrane cell-adhesion protein that serves as an entry receptor for...
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Does Manganese Contribute to Methamphetamine-Induced Psychosis?
Purpose of ReviewThis review describes the increasing global problem of methamphetamine (MA) use and development of psychosis, the molecular and...
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SorCS2 is required for social memory and trafficking of the NMDA receptor
Social memory processing requires functional CA2 neurons, however the specific mechanisms that regulate their activity are poorly understood. Here,...
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Thoughts on the popularity of ICSI
PurposeIntracytoplasmic sperm injection (ICSI) is the most widely utilized assisted reproductive technique (ART) worldwide. In this feature, we...
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The role of glutamate transporters in the pathophysiology of neuropsychiatric disorders
Altered glutamate transporter expression is a common feature of many neuropsychiatric conditions, including schizophrenia. Excitatory amino acid...
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Postsynaptic movement disorders: clinical phenotypes, genotypes, and disease mechanisms
Movement disorders comprise a group of heterogeneous diseases with often complex clinical phenotypes. Overlapping symptoms and a lack of diagnostic...
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Overexpression of Protein Kinase Mζ in the Prelimbic Cortex Enhances the Formation of Long-Term Fear Memory
Neuroplasticity in the prefrontal cortex (PFC) after fear conditioning has been suggested to regulate the formation and expression of fear memory....
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Cell-specific abnormalities of glutamate transporters in schizophrenia: sick astrocytes and compensating relay neurons?
Excitatory amino-acid transporters (EAATs) bind and transport glutamate, limiting spillover from synapses due to their dense perisynaptic expression...
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Genetic aspects of monomorphic teratozoospermia: a review
Teratozoospermia is characterized by the presence of spermatozoa with abnormal morphology over 85 % in sperm. When all the spermatozoa display a...
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Syntenin regulates TGF-β1-induced Smad activation and the epithelial-to-mesenchymal transition by inhibiting caveolin-mediated TGF-β type I receptor internalization
Syntenin, a tandem PDZ domain containing scaffold protein, functions as a positive regulator of cancer cell progression in several human cancers. We...
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Clinical Association Between Pharmacogenomics and Adverse Drug Reactions
Adverse drug reactions (ADRs) are a major public health concern and cause significant patient morbidity and mortality. Pharmacogenomics is the study...
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Postmortem Brain: An Underutilized Substrate for Studying Severe Mental Illness
We propose that postmortem tissue is an underutilized substrate that may be used to translate genetic and/or preclinical studies, particularly for...
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Pathogenic disruption of DISC1-serine racemase binding elicits schizophrenia-like behavior via D-serine depletion
Perturbation of Disrupted-In-Schizophrenia-1 (DISC1) and D -serine/NMDA receptor hypofunction have both been implicated in the pathophysiology of...
