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Contactin-associated protein-like 2 (CNTNAP2) mutations impair the essential α-secretase cleavages, leading to autism-like phenotypes
Mutations in the Contactin-associated protein-like 2 ( CNTNAP2 ) gene are associated with autism spectrum disorder (ASD), and ectodomain shedding of...
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Thy1-ApoE4/C/EBPβ double transgenic mice act as a sporadic model with Alzheimer’s disease
Early onset familial Alzheimer’s disease (FAD) with APP, PS1/2 (presenilins) mutation accounts for only a small portion of AD cases, and most are...
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An insight into Alzheimer’s disease and its on-setting novel genes
According to the World Health Organisation, as of 2019, globally around 50 million people suffer from dementia, with approximately another 10 million...
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CNTNAP2 intracellular domain (CICD) generated by γ-secretase cleavage improves autism-related behaviors
As the most prevalent neurodevelopmental disorders in children, autism spectrum disorders (ASD) are characterized by deficits in language...
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The relationship of early- and late-onset Alzheimer’s disease genes with COVID-19
Individuals with Alzheimer’s disease and other neurodegenerative diseases have been exposed to excess risk by the COVID-19 pandemic. COVID-19’s main...
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Notch signaling pathway: a new target for neuropathic pain therapy
The Notch gene, a highly evolutionarily conserved gene, was discovered approximately 110 years ago and has been found to play a crucial role in the...
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Targeting the molecular web of Alzheimer’s disease: unveiling pathways for effective pharmacotherapy
IntroductionAlzheimer’s disease is a neurocognitive disorder that affects elderly people by slowly impaired cognition, dementia, and gets worse with...
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Neuronal hyperexcitability in Alzheimer’s disease: what are the drivers behind this aberrant phenotype?
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder leading to loss of cognitive abilities and ultimately, death. With no cure...
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FGFR2 Controls Growth, Adhesion and Migration of Nontumorigenic Human Mammary Epithelial Cells by Regulation of Integrin β1 Degradation
The role of fibroblast growth factor receptor 2 (FGFR2), an important mediator of stromal paracrine and autocrine signals, in mammary gland...
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The Amyloid-β Pathway in Alzheimer’s Disease
Breakthroughs in molecular medicine have positioned the amyloid-β (Aβ) pathway at the center of Alzheimer’s disease (AD) pathophysiology. While the...
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Chimeric cerebral organoids reveal the essentials of neuronal and astrocytic APOE4 for Alzheimer’s tau pathology
The apolipoprotein E4 ( APOE4 ) genotype is one of the strongest genetic risk factors for Alzheimer’s disease (AD), and is generally believed to cause...
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Remodeling without destruction: non-proteolytic ubiquitin chains in neural function and brain disorders
Ubiquitination is a fundamental posttranslational protein modification that regulates diverse biological processes, including those in the CNS....
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The prohibitin-binding compound fluorizoline inhibits mitophagy in cancer cells
Fluorizoline is a prohibitin-binding compound that triggers apoptosis in several cell lines from murine and human origin, as well as in primary cells...
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Hippocampal delivery of neurotrophic factor-α1/carboxypeptidase E gene prevents neurodegeneration, amyloidosis, memory loss in Alzheimer’s Disease male mice
Alzheimer’s Disease (AD) is a prevalent neurodegenerative disease characterized by tau hyperphosphorylation, Aβ1-42 aggregation and cognitive...
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Advanced molecular therapies for neurological diseases: focus on stroke, alzheimer's disease, and parkinson's disease
Neurological diseases (NDs) are one of the leading causes of disability and the second leading cause of death globally. Among these stroke,...
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The Development of Pharmacological Therapies for Alzheimer’s Disease
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that currently has no cure. The aged population is growing globally, creating an...
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Abelmoschus esculentus subfractions attenuate Aβ and tau by regulating DPP-4 and insulin resistance signals
BackgroundInsulin resistance could be associated with the development of Alzheimer disease (AD). The neuropathological hallmarks of AD are beta...
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The puzzle of preserved cognition in the oldest old
Although epidemiological studies predict an exponential increase in the prevalence of dementia with age, recent studies have demonstrated that the...
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Synaptic degeneration in Alzheimer disease
Alzheimer disease (AD) is characterized by progressive cognitive decline in older individuals accompanied by the presence of two pathological protein...
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Alzheimer-related genes show accelerated evolution
Alzheimerʼs disease (AD) is a neurodegenerative disorder of unknown cause with complex genetic and environmental traits. While AD is extremely...
