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Value of preclinical systematic reviews and meta-analyses in pediatric research
AbstractSimilar to systematic reviews (SRs) in clinical fields, preclinical SRs address a specific research area, furnishing information on current...
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MIB Guides: Preclinical Radiopharmaceutical Dosimetry
Preclinical dosimetry is essential for guiding the design of animal radiopharmaceutical biodistribution, imaging, and therapy experiments, evaluating...
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Introduction to surgery in preclinical years: curriculum development and impact
PurposeExposure to surgery in preclinical years of medical school is traditionally very limited. It is estimated that 59% of students make their...
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Deciphering the different phases of preclinical inflammatory bowel disease
Inflammatory bowel disease (IBD) is an immune-mediated inflammatory disease (IMID) of the gastrointestinal tract and includes two subtypes: Crohn’s...
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Mesenchymal stem cell based therapies for uveitis: a systematic review of preclinical studies
Cell therapy has shown promising results for treating uveitis in preclinical studies. As the field continues to grow towards clinical translation, it...
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“Expression of concern”: publication bias for positive preclinical cardioprotection studies
The present analysis reports on the robustness of preclinical cardioprotection studies with infarct size as endpoint which were published in Basic...
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Targeting histone modifiers in bladder cancer therapy — preclinical and clinical evidence
Bladder cancer in the most advanced, muscle-invasive stage is lethal, and very limited therapeutic advances have been reported for decades. To date,...
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Preclinical magnetic resonance imaging and spectroscopy in the fields of radiological technology, medical physics, and radiology
Magnetic resonance imaging (MRI) is an indispensable diagnostic imaging technique used in the clinical setting. MRI is advantageous over X-ray and...
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IDH inhibition in gliomas: from preclinical models to clinical trials
Gliomas are the most common malignant primary brain tumours in adults and cannot usually be cured with standard cancer treatments. Gliomas show...
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Perinatal compromise affects development, form, and function of the hippocampus part two; preclinical studies
AbstractThe hippocampus is a vital brain structure deep in the medial temporal lobe that mediates a range of functions encompassing emotional...
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Preclinical SPECT and PET: Joint EANM and ESMI procedure guideline for implementing an efficient quality control programme
The aim of this guideline is to provide recommendations for the implementation of an effective and efficient quality control (QC) programme for SPECT...
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Can current preclinical strategies for radiopharmaceutical development meet the needs of targeted alpha therapy?
Preclinical studies are essential for effectively evaluating TAT radiopharmaceuticals. Given the current suboptimal supply chain of these...
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Preclinical models of bladder cancer: BBN and beyond
Preclinical modelling is a crucial component of advancing the understanding of cancer biology and therapeutic development. Several models exist for...
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Criteria for preclinical models of cholangiocarcinoma: scientific and medical relevance
Cholangiocarcinoma (CCA) is a rare malignancy that develops at any point along the biliary tree. CCA has a poor prognosis, its clinical management...
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Transmural cross-sectional findings and bowel damage assessment in preclinical Crohn’s disease: a case-control study
PurposeCrohn’s disease (CD) is a progressive disorder leading to cumulative bowel damage. The Lémann index is a validated tool that can help in...
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Nuclear-Based Labeling of Cellular Immunotherapies: A Simple Protocol for Preclinical Use
Labeling and tracking existing and emerging cell-based immunotherapies using nuclear imaging is widely used to guide the preclinical phases of...
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Evaluating the Performance of Different Criteria in Diagnosing AD and Preclinical AD with the Bayesian Latent Class Model
BackgroundThe diagnostic criteria for Alzheimer’s disease (AD) should be highly sensitive and specific. Clinicians have varying opinions on the...
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Recommendations for robust and reproducible preclinical research in personalised medicine
BackgroundPersonalised medicine is a medical model that aims to provide tailor-made prevention and treatment strategies for defined groups of...
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Substance use and spine density: a systematic review and meta-analysis of preclinical studies
The elucidation of synaptic density changes provides valuable insights into the underlying brain mechanisms of substance use. In preclinical studies,...
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Impaired learning, memory, and extinction in posttraumatic stress disorder: translational meta-analysis of clinical and preclinical studies
Current evidence-based treatments for post-traumatic stress disorder (PTSD) are efficacious in only part of PTSD patients. Therefore, novel...
