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Genetic forms of tauopathies: inherited causes and implications of Alzheimer’s disease-like TAU pathology in primary and secondary tauopathies
Tauopathies are a heterogeneous group of neurologic diseases characterized by pathological axodendritic distribution, ectopic expression, and/or...
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FDG-PET in the diagnosis of primary progressive aphasia: a systematic review
Primary progressive aphasia (PPA) is a disease known to affect the frontal and temporal regions of the left hemisphere. PPA is often an indication of...
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Single-nucleus chromatin accessibility profiling highlights distinct astrocyte signatures in progressive supranuclear palsy and corticobasal degeneration
Tauopathies such as progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) exhibit characteristic neuronal and glial inclusions of...
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Identification of high-performing antibodies for the reliable detection of Tau proteoforms by Western blotting and immunohistochemistry
Antibodies are essential research tools whose performance directly impacts research conclusions and reproducibility. Owing to its central role in...
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Repetitive head impacts and chronic traumatic encephalopathy are associated with TDP-43 inclusions and hippocampal sclerosis
Hippocampal sclerosis (HS) is associated with advanced age as well as transactive response DNA-binding protein with 43 kDa (TDP-43) deposits. Both...
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Accuracy of routinely collected hospital administrative discharge data and death certificate ICD-10 diagnostic coding in progressive supranuclear palsy and corticobasal syndrome: a systematic review and validation study
BackgroundWe conducted a systematic review to identify existing ICD-10 coding validation studies in progressive supranuclear palsy and corticobasal...
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Ultrastructural and biochemical classification of pathogenic tau, α-synuclein and TDP-43
Intracellular accumulation of abnormal proteins with conformational changes is the defining neuropathological feature of neurodegenerative diseases....
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The contribution of β-amyloid, Tau and α-synuclein to blood–brain barrier damage in neurodegenerative disorders
Central nervous system (CNS) accumulation of fibrillary deposits made of Amyloid β (A β ), hyperphosphorylated Tau or α -synuclein ( α -syn), present...
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Investigating drug–target interactions in frontotemporal dementia using a network pharmacology approach
BackgroundFrontotemporal dementia (FTD) is the second most common type of dementia in individuals aged below 65 years with no current cure. Current...
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Pathomechanisms of cognitive and behavioral impairment in corticobasal degeneration
Corticobasal degeneration (CBD) is a rare, sporadic, late-onset progressive neurodegenerative disorder of unknown etiology, clinically characterized...
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Exploring experiences and needs of spousal carers of people with behavioural variant frontotemporal dementia (bvFTD) including those with familial FTD (fFTD): a qualitative study
IntroductionCarers of people with frontotemporal dementia (FTD) experience greater challenges than carers of people with other dementias due to the...
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Rainwater Charitable Foundation criteria for the neuropathologic diagnosis of progressive supranuclear palsy
Neuropathologic criteria for progressive supranuclear palsy (PSP) proposed by a National Institute of Neurological Disorders and Stroke (NINDS)...
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Premorbid de novo artistic creativity in frontotemporal dementia (FTD) syndromes
The emergence of new artistic activities or shifts in artistic style in patients with frontotemporal dementia (FTD) syndromes is well documented at...
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Chinese nutraceuticals and physical activity; their role in neurodegenerative tauopathies
The onset of neurodegenerative disease has not only been a major cause of scientific worry, but of economic burden to the health system. This...
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Patterns of neuronal Rhes as a novel hallmark of tauopathies
The farnesyltransferase inhibitor, Lonafarnib, reduces tau inclusions and associated atrophy in familial tauopathy models through activation of...
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Poly-glycine–alanine exacerbates C9orf72 repeat expansion-mediated DNA damage via sequestration of phosphorylated ATM and loss of nuclear hnRNPA3
Repeat expansion in C9orf72 causes amyotrophic lateral sclerosis and frontotemporal lobar degeneration. Expanded sense and antisense repeat RNA...
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Effect of GAPT extract on expression of tau protein and its phosphorylation related enzymes in hippocampal neurons of APPV717I transgenic mice
ObjectiveTo investigate the effect of GAPT, an extract mixture from Radix Ginseng, Rhizoma Acor tatarinowii, Radix Polygalae and Radix Curcuma...
