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PGT-A: Houston, we have a problem
Preimplantation genetic testing for aneuploidy (PGT-A) is a common add-on to IVF cycles. As it is presently performed, PGT-A relies on whole genome...
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Combining PGT-A with PGT-M risks trying to do too much
The primary objective of preimplantation genetic testing for monogenic disorders (PGT-M) is to avoid having a child with a serious monogenic disease....
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PGT-M for spinocerebellar ataxia type 1: development of a STR panel and a report of two clinical cases
PurposeTo present the developed preimplantation genetic testing (PGT) for spinocerebellar ataxia type 1 (SCA1) and the outcomes of IVF with PGT.
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High-resolution PGT-A results in incidental identification of patients with small pathogenic copy number variants
PurposeThis study aimed to evaluate whether a high-throughput high-resolution PGT-A method can detect copy number variants (CNVs) that could have...
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Current Applications and Controversies in Preimplantation Genetic Testing for Aneuploidies (PGT-A) in In Vitro Fertilization
Preimplantation genetic testing for aneuploidy (PGT-A) has evolved over recent years, including improvements in embryo culture, biopsy, transfer, and...
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A clinical predictive model for live birth in women of advanced age undergoing PGT cycles
PurposeThe trend of delaying childbirth has resulted in a growing number of advanced-aged women who are opting for preimplantation genetic testing...
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Mosaic embryo transfer versus additional IVF with PGT-A Cycle: a decision model comparing live birth rate and cost
PurposeTo evaluate the relative live birth rate and net cost difference between mosaic embryo transfer and an additional cycle of IVF with PGT-A for...
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Elucidating the PGT-A paradox: marginalising the detriment relegates the benefit
The hypothetical analysis presented offers insight into the effect of maternal age and protocol on the cost-effectiveness of PGT-A to reduce the risk...
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Embryo drop-out rates in preimplantation genetic testing for aneuploidy (PGT-A): a retrospective data analysis from the DoLoRes study
PurposeTo evaluate the decline in transferable embryos in preimplantation genetic testing for aneuploidy (PGT-A) cycles due to (a) non-biopsable...
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Identification of cryptic balanced translocations in couples with unexplained recurrent pregnancy loss based upon embryonic PGT-A results
PurposeThe goal of this study is to determine whether any balanced translocation (BT) had been missed by previous karyotyping in patients with...
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PGT-A improved singleton live birth rate among all age groups of women who underwent elective single blastocyst transfer: a single-centre retrospective study
PurposeThis study assessed the difference in singleton live birth rate (SLBR) between preimplantation genetic testing for aneuploidy (PGT-A) and...
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Cost-effectiveness of IVF with PGT-M/A to prevent transmission of spinal muscular atrophy in offspring of carrier couples
PurposeTo evaluate the cost-effectiveness of in-vitro fertilization with preimplantation genetic testing for aneuploidy and monogenic disorders (IVF...
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An Incidental Detection of a Rare UPD in SNP-Array Based PGT-SR: A Case Report
Uniparental disomies (UPD) refers to the inheritance of both homologs of a chromosome from only one parent with no representative copy from the other...
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AMH independently predicts aneuploidy but not live birth per transfer in IVF PGT-A cycles
BackgroundWhile anti-Müllerian hormone (AMH) predicts quantitative IVF outcomes such as oocyte yield, it is not certain whether AMH predicts markers...
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The impact of a second embryo biopsy for preimplantation genetic testing for monogenic diseases (PGT-M) with inconclusive results on pregnancy potential: results from a matched case–control study
PurposeTo evaluate whether a second biopsy, following a first diagnostic failure on blastocysts tested for preimplantation genetic testing for...
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Previously reported and here added cases demonstrate euploid pregnancies followed by PGT-A as “mosaic” as well as “aneuploid” designated embryos
BackgroundAfter the longest time opposing all transfers of embryos by preimplantation genetic testing for aneuploidy (PGT-A) diagnosed as...
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What to advise to patients with only one good quality blastocyst, PGT-A or not? Outcomes of 2064 cycles
PurposeTo evaluate whether preimplantation genetic testing for aneuploidy (PGT-A) is beneficial for patients who have only one blastocyst available...
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Preimplantation genetic testing for monogenic disorders (PGT-M) offers an alternative strategy to prevent children from being born with hereditary neurological diseases or metabolic diseases dominated by nervous system phenotypes: a retrospective study
BackgroundPreimplantation genetic testing for monogenic disorders (PGT-M) is now widely used as an effective strategy to prevent various monogenic or...
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Outcomes of random-start letrozole protocol with PGT-A in women with breast cancer undergoing fertility preservation
PurposeTo compare the cycle characteristics and outcomes of random-start-controlled ovarian stimulation (RSCOS) protocols to the outcomes of...
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Association of embryo aneuploidy and sperm DNA damage in unexplained recurrent implantation failure patients under NGS-based PGT-A cycles
PurposeRecurrent implantation failure (RIF) is one of the most common conditions affecting In Vitro Fertilization (IVF)/Intracytoplasmic sperm...
