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Molecular mechanisms of cellular dysfunction in testes from men with non-obstructive azoospermia
Male factor infertility affects 50% of infertile couples worldwide; the most severe form, non-obstructive azoospermia (NOA), affects 10–15% of...
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Hormonal markers as noninvasive predictors of sperm retrieval in non-obstructive azoospermia
Non-obstructive azoospermia (NOA) is one of the leading causes of male factor infertility, which results from impaired spermatogenesis. Currently,...
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Idiopathic secondary azoospermia occurrence in men with oligospermia over time
PurposeTo investigate the occurrence of idiopathic secondary azoospermia (ISA) in men with oligospermia over time and identify risk factors for ISA...
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A novel ADGRG2 truncating variant associated with X-linked obstructive azoospermia in a large Chinese pedigree
PurposeIn this study, we aimed to identify sterility-related variants in a Chinese pedigree with male infertility and to reveal the different...
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Y chromosome microdeletions in Chinese men with infertility: prevalence, phenotypes, and intracytoplasmic sperm injection outcomes
BackgroundThe incidence of Y chromosome microdeletions varies among men with infertility across regions and ethnicities worldwide. However,...
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Prolactin and spermatogenesis: new lights on the interplay between prolactin and sperm parameters
PurposeTo clarify the relationship between one the most gender-specific hormone, i.e. prolactin (PRL), and semen parameters in men.
Methods ... -
Sperm chromosomal abnormalities in infertile men with failed intracytoplasmic sperm injection (ICSI)
BackgroundMale infertility is a major health problem with multi-factorial etiology. Intracytoplasmic sperm injection (ICSI) has revolutionized the...
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The Germ Cell–Specific Markers ZPBP2 and PGK2 in Testicular Biopsies Can Predict the Presence as well as the Quality of Sperm in Non-obstructive Azoospermia Patients
To assess the role of three testis-specific genes including ZPBP2 , PGK2 , and ACRV1 in the prediction of sperm retrieval result and quality of...
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Does ICSI outcome in obstructive azoospermia differ according to the origin of retrieved spermatozoa or the cause of epididymal obstruction? A comparative study
PurposeTo determine whether ICSI outcomes are affected by sperm source or genital tract inflammatory status.
MethodsA retrospective cohort study was...
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In cases with raised sperm DNA fragmentation, can sperm selection by magnetic-activated cell sorting or testicular sperm aspiration help improve reproductive outcomes?
PurposeTo evaluate the efficacy of magnetic-activated cell sorting (MACS) or testicular sperm aspiration (TESA) to improve reproductive outcomes in...
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Role of microsurgical varicocelectomy in the management of non-obstructive azoospermia with varicocele: our tertiary care centre experience
BackgroundVaricocele is an abnormal dilation and tortuosity of the internal spermatic veins within the pampiniform plexus of the spermatic cord....
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Switching to testicular sperm after a previous ICSI failure with ejaculated sperm significantly improves blastocyst quality without increasing aneuploidy risk
PurposeThe use of testicular sperm is confined to patients with azoospermia, but there is evidence to support its use in males with poor semen...
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Methylation Status of cAMP-responsive Element Modulator (CREM) Gene in Infertile Men and Its Association with Sperm Parameters
The methylation pattern of non-imprinting genes was little studied, although it is widely known that the abnormal methylation levels of imprinting...
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The predictive factors of successful sperm retrieval for men with Y chromosome AZFc microdeletion
PurposeTo identify key predictors for successful sperm retrieval in men with AZFc microdeletion.
MethodsTotally, 71 infertile men with confirmed...
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Microdissection testicular sperm extraction (micro-TESE) in men with infertility due to nonobstructive azoospermia: summary of current literature
PurposeNonobstructive azoospermia (NOA) is associated with intrinsic testicular defects that severely impair sperm production. Although NOA...
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Genetic profiling of azoospermic men to identify the etiology and predict reproductive potential
PurposeTo identify germline mutations related to azoospermia etiology and reproductive potential of surgically retrieved spermatozoa, and to...
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Quality of testicular spermatozoa improves with changes in composition of culture medium
BackgroundSpermatozoa retrieved from the testis and epididymis are deprived of the beneficial effects of seminal fluid. Thus applying an artificial...
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Sperm miR-34c-5p Transcript Content and Its Association with Sperm Parameters in Unexplained Infertile Men
MicroRNAs (miRNAs) play an essential role in regulatory functions during gametogenesis. There is evidence that dysregulation of miR-34c-5p is...
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Clinical, cytogenomic, and molecular characterization of isodicentric Y-chromosome and prediction of testicular sperm retrieval outcomes in azoospermic and severe oligozoospermic infertile men
PurposeSex chromosome abnormalities are associated with male infertility. The aim of this study was to characterize the clinical, cytogenetic, and...
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A loss-of-function variant in ZCWPW1 causes human male infertility with sperm head defect and high DNA fragmentation
BackgroundMale infertility is a global health issue. The more causative genes related to human male infertility should be further explored. The...
