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Introducing neurofilament light chain measure in psychiatry: current evidence, opportunities, and pitfalls
The recent introduction of new-generation immunoassay methods allows the reliable quantification of structural brain markers in peripheral matrices....
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Serum levels of neurofilament light chains in pediatric multiple sclerosis: a systematic review and meta-analysis
BackgroundMultiple sclerosis is a neuro-inflammatory disease that affects adults and children and causes somatic and cognitive symptoms. Diagnosis...
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Serum neurofilament light as a predictor of outcome in subarachnoid haemorrhage
BackgroundPrognostication of clinical outcome in patients suffering from aneurysmal subarachnoid haemorrhage (SAH) is a challenge. There are no...
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Plasma neurofilament light as a promising biomarker in neuronal intranuclear inclusion disease
Neuronal intranuclear inclusion disease (NIID) is a rare neurodegenerative disorder lacking reliable biomarkers. This study investigates plasma...
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Serum neurofilament light chain in COVID-19 and the influence of renal function
COVID-19 is associated with various neurological symptoms. Serum neurofilament light chain (sNfL) is a robust marker for neuroaxonal injury. Recent...
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Neurofilament light as a predictor of long- and short-term outcomes in critically ill children
PurposePlasma neurofilament light (NFL) is a marker of neuronal injury, associated with poor neurological outcomes in adults and neonates in a wide...
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Blood neurofilament light chain in Parkinson’s disease
Blood neurofilament light chain (NfL) is an easily accessible, highly sensitive and reliable biomarker for neuroaxonal damage. Currently, its role in...
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Neurofilament light chains to assess sepsis-associated encephalopathy: Are we on the track toward clinical implementation?
Sepsis is the most common cause of admission to intensive care units worldwide. Sepsis patients frequently suffer from sepsis-associated...
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Correlation analysis between smoke exposure and serum neurofilament light chain in adults: a cross-sectional study
BackgroundSmoke exposure is a prevalent and well-documented risk factor for various diseases across different organ systems. Serum neurofilament...
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Serum neurofilament light chain associates with symptom burden in Lyme neuroborreliosis patients: a longitudinal cohort study from Norway
ObjectivesSerum neurofilament light chain (sNfL), an indicator of neuronal damage, is increasingly recognized as a potential biomarker for disease...
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Serum neurofilament light chain levels in migraine patients: a monocentric case–control study in China
PurposeSerum neurofilament light chain (sNfL) can reflect nerve damage. Whether migraine can cause neurological damage remain unclear. This study...
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Plasma concentrations of glial fibrillary acidic protein, neurofilament light, and tau in Alexander disease
IntroductionAlexander disease (AxD) is a rare leukodystrophy caused by dominant gain-of-function mutations in the gene encoding the astrocyte...
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Association Between Serum Neurofilament Light Chain and Cognitive Performance Among Older Adults in the United States: A Cross-Sectional Study
IntroductionSerum neurofilament light chain (sNfL) is an emerging biomarker of neuronal damage in several neurological disorders. Its association...
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Bronchopulmonary dysplasia is not related to neurofilament light for neuroaxonal damage in preterm infants
BackgroundNeurofilament light (NfL) has been identified as a biomarker for neuroaxonal damage in preterm infants, but its relation with...
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Neurofilament Light Chain in Adult and Pediatric Multiple Sclerosis: A Promising Biomarker to Better Characterize Disease Activity and Personalize MS Treatment
Many biological markers have been explored in multiple sclerosis (MS) to better quantify disease burden and better evaluate response to treatments,...
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Long COVID: plasma levels of neurofilament light chain in mild COVID-19 patients with neurocognitive symptoms
It is well known the potential of severe acute respiratory coronavirus type 2 (SARS-CoV-2) infection to induce post-acute sequelae, a condition...
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Neurofilament light chain: a promising diagnostic biomarker for functional motor disorders
ObjectiveFunctional motor disorders (FMDs) are disabling neurological conditions characterized by abnormal movements which are inconsistent and...
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Plasma neurofilament light admission levels and development of axonal pathology in mild traumatic brain injury
BackgroundIt is known that blood levels of neurofilament light (NF-L) and diffusion-weighted magnetic resonance imaging (DW-MRI) are both associated...
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Cluster analysis dissecting cognitive deficits in older adults with major depressive disorder and the association with neurofilament light chain
BackgroundCognitive impairment is a growing problem with increasing burden in global aging. Older adults with major depressive disorder (MDD) have...
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Serum neurofilament light chain as a prognostic marker of all-cause mortality in a national sample of US adults
Neurofilament light chain (NfL) is a neuron-specific structural protein released into the extracellular space, including body fluids, upon...
