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An ultra-small organic dye nanocluster for enhancing NIR-II imaging-guided surgery outcomes
PurposeThe accuracy of surgery for patients with solid tumors can be greatly improved through fluorescence-guided surgery (FGS). However, existing...
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PET/NIR-II fluorescence imaging and image-guided surgery of glioblastoma using a folate receptor α-targeted dual-modal nanoprobe
PurposeThe surgery of glioblastoma (GBM) requires a maximal resection of the tumor when it is safe and feasible. The infiltrating growth property of...
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NIR-II light in clinical oncology: opportunities and challenges
Novel strategies utilizing light in the second near-infrared region (NIR-II; 900–1,880 nm wavelengths) offer the potential to visualize and treat...
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Enhancing surgical outcomes: accurate identification and removal of prostate cancer with B7-H3-targeted NIR-II molecular imaging
PurposeOne of the main reasons for prostate cancer (PCa) recurrence is the difficulty in identifying and removing cancerous lesions during surgery....
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The current status and future prospects for molecular imaging-guided precision surgery
Molecular imaging technologies are increasingly used to diagnose, monitor, and guide treatment of i.e., cancer. In this review, the current status...
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Lessons learned in application driven imaging agent design for image-guided surgery
To meet the growing demand for intraoperative molecular imaging, the development of compatible imaging agents plays a crucial role. Given the unique...
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Prospective validation of tumor folate receptor expression density with the association of pafolacianine fluorescence during intraoperative molecular imaging–guided lung cancer resections
PurposePafolacianine, a folate receptor alpha-targeted NIR tracer, has demonstrated clear efficacy in intraoperative molecular imaging–guided (IMI)...
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Molecular image–guided surgery in gynaecological cancer: where do we stand?
PurposeThe aim of this review is to give an overview of the current status of molecular image–guided surgery in gynaecological malignancies, from...
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Identification of a Suitable Untargeted Agent for the Clinical Translation of ABY-029 Paired-Agent Imaging in Fluorescence-Guided Surgery
PurposeNon-specific uptake and retention of molecular targeted agents and heterogeneous tissue optical properties diminish the ability to...
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The Evolution of Fluorescence-Guided Surgery
There has been continual development of fluorescent agents, imaging systems, and their applications over the past several decades. With the recent...
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Near-infrared fluorescence imaging-guided lymphatic mapping in thoracic esophageal cancer surgery
PurposeIdentifying the lymphatic drainage pathway is important for accurate lymph node (LN) dissection in esophageal cancer (EC). This study aimed to...
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Clinical translation and implementation of optical imaging agents for precision image-guided cancer surgery
IntroductionThe field of tumor-specific fluorescence-guided surgery has seen a significant increase in the development of novel tumor-targeted...
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Detection of Residual Peritoneal Metastases Following Cytoreductive Surgery Using Pegsitacianine, a pH-Sensitive Imaging Agent: Final Results from a Phase II Study
BackgroundFor patients with peritoneal carcinomatosis, extent of disease and completeness of cytoreductive surgery (CRS) are major prognostic factors...
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Cysteine Cathepsins in Breast Cancer: Promising Targets for Fluorescence-Guided Surgery
The majority of breast cancer patients is treated with breast-conserving surgery (BCS) combined with adjuvant radiation therapy. Up to 40% of...
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Comparative Study of Indocyanine Green Fluorescence Imaging in Lung Cancer with Near-Infrared-I/II Windows
BackgroundWe compare the application of intravenous indocyanine green (ICG) fluorescence imaging in lung cancer with near-infrared-I (NIR-I) and...
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Evaluation of OTL38-Generated Tumor-to-Background Ratio in Intraoperative Molecular Imaging-Guided Lung Cancer Resections
IntroductionCancer surgery has multiple challenges including localizing small lesions, ensuring negative margins, and identifying synchronous...
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A Standardized Framework for Fluorescence-Guided Margin Assessment for Head and Neck Cancer Using a Tumor Acidosis Sensitive Optical Imaging Agent
PurposeIntra-operative management of the surgical margin in patients diagnosed with head and neck squamous cell carcinoma (HNSCC) remains challenging...
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Fundamentals and developments in fluorescence-guided cancer surgery
Fluorescence-guided surgery using tumour-targeted imaging agents has emerged over the past decade as a promising and effective method of...
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Lung cancer surgery: innovations and future perspectives
Nine decades ago in 1933, Evarts A. Graham performed the first successful pneumonectomy in a patient with primary pulmonary squamous cell carcinoma....
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Effective application of indocyanine green for visualization of the thoracic duct during video-assisted thoracoscopic surgery for chylothorax: a case report
BackgroundChylothorax is an accumulation of typically milky-appearing lymphatic fluid within the pleural cavity. High-output chylothorax may lead to...
