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NIR-II light in clinical oncology: opportunities and challenges
Novel strategies utilizing light in the second near-infrared region (NIR-II; 900–1,880 nm wavelengths) offer the potential to visualize and treat...
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An ultra-small organic dye nanocluster for enhancing NIR-II imaging-guided surgery outcomes
PurposeThe accuracy of surgery for patients with solid tumors can be greatly improved through fluorescence-guided surgery (FGS). However, existing...
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Enhancing surgical outcomes: accurate identification and removal of prostate cancer with B7-H3-targeted NIR-II molecular imaging
PurposeOne of the main reasons for prostate cancer (PCa) recurrence is the difficulty in identifying and removing cancerous lesions during surgery....
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PET/NIR-II fluorescence imaging and image-guided surgery of glioblastoma using a folate receptor α-targeted dual-modal nanoprobe
PurposeThe surgery of glioblastoma (GBM) requires a maximal resection of the tumor when it is safe and feasible. The infiltrating growth property of...
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Near-infrared II theranostic agents for the diagnosis and treatment of Alzheimer’s disease
BackgroundNear-infrared II theranostic agents have gained great momentum in the research field of AD owing to the appealing advantages. Recently, an...
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Time required for indocyanine green fluorescence emission for evaluating bowel perfusion in left-sided colon and rectal cancer surgery
BackgroundIndocyanine green fluorescence imaging (ICG-FI) has been reported to be useful in reducing the incidence of anastomotic leakage (AL) in...
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Comparative Study of Indocyanine Green Fluorescence Imaging in Lung Cancer with Near-Infrared-I/II Windows
BackgroundWe compare the application of intravenous indocyanine green (ICG) fluorescence imaging in lung cancer with near-infrared-I (NIR-I) and...
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Optical molecular imaging and theranostics in neurological diseases based on aggregation-induced emission luminogens
Optical molecular imaging and image-guided theranostics benefit from special and specific imaging agents, for which aggregation-induced emission...
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Recent advances in aggregation-induced emission luminogens in photoacoustic imaging
Photoacoustic imaging (PAI) is a rapidly emerging modality in biomedical research with the advantages of noncontact operation, high optical...
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Identification of a CEACAM5 targeted nanobody for positron emission tomography imaging and near-infrared fluorescence imaging of colorectal cancer
PurposeHere, we aim to identify a CEACAM5-targeted nanobody and demonstrate its application in positron emission tomography (PET) imaging and...
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Molecular fluorophores for in vivo bioimaging in the second near-infrared window
PurposeThis systematic review aims to summarize the current developments of fluorescence and chemi/bioluminescence imaging based on the molecular...
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Nd-Mn Molecular Cluster with Searched Targets for Oral Cancer Imaging
In this research, we designed a novel NIR II luminescence imaging probe with targeting effect to accurately track oral squamous cell carcinoma (OSCC)...
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Targeted detection of cancer cells during biopsy allows real-time diagnosis of pulmonary nodules
BackgroundThe diagnostic yield of biopsies of solitary pulmonary nodules (SPNs) is low, particularly in sub-solid lesions. We developed a method...
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Non-oncological applications of RGD-based single-photon emission tomography and positron emission tomography agents
IntroductionNon-invasive imaging techniques (especially single-photon emission tomography and positron emission tomography) apply several RGD-based...
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New and effective EGFR-targeted fluorescence imaging technology for intraoperative rapid determination of lung cancer in freshly isolated tissue
PurposeDuring lung cancer surgery, it is very important to define tumor boundaries and determine the surgical margin distance. In previous research,...
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Recent Advances of Organic Near-Infrared II Fluorophores in Optical Properties and Imaging Functions
Near-infrared (NIR) fluorescence imaging (FI) has become a research hotspot because of its distinctive imaging properties: high temporal resolution...
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Presence of non-Newtonian fluid in invasive pulmonary mucinous adenocarcinomas impacts fluorescence during intraoperative molecular imaging of lung cancer
BackgroundIntraoperative molecular imaging (IMI) with folate-targeted NIR tracers has been shown to improve lesion localization in more than 80% of...
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Activatable fluorescent probes for imaging and diagnosis of rheumatoid arthritis
Rheumatoid arthritis (RA) is a systemic autoimmune disease that is primarily manifested as synovitis and polyarticular opacity and typically leads to...
