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An ultra-small organic dye nanocluster for enhancing NIR-II imaging-guided surgery outcomes
PurposeThe accuracy of surgery for patients with solid tumors can be greatly improved through fluorescence-guided surgery (FGS). However, existing...
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NIR-II light in clinical oncology: opportunities and challenges
Novel strategies utilizing light in the second near-infrared region (NIR-II; 900–1,880 nm wavelengths) offer the potential to visualize and treat...
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Enhancing surgical outcomes: accurate identification and removal of prostate cancer with B7-H3-targeted NIR-II molecular imaging
PurposeOne of the main reasons for prostate cancer (PCa) recurrence is the difficulty in identifying and removing cancerous lesions during surgery....
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PET/NIR-II fluorescence imaging and image-guided surgery of glioblastoma using a folate receptor α-targeted dual-modal nanoprobe
PurposeThe surgery of glioblastoma (GBM) requires a maximal resection of the tumor when it is safe and feasible. The infiltrating growth property of...
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Near-infrared II theranostic agents for the diagnosis and treatment of Alzheimer’s disease
BackgroundNear-infrared II theranostic agents have gained great momentum in the research field of AD owing to the appealing advantages. Recently, an...
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Molecular fluorophores for in vivo bioimaging in the second near-infrared window
PurposeThis systematic review aims to summarize the current developments of fluorescence and chemi/bioluminescence imaging based on the molecular...
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POD Nanozyme optimized by charge separation engineering for light/pH activated bacteria catalytic/photodynamic therapy
The current feasibility of nanocatalysts in clinical anti-infection therapy, especially for drug-resistant bacteria infection is extremely restrained...
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Lessons learned in application driven imaging agent design for image-guided surgery
To meet the growing demand for intraoperative molecular imaging, the development of compatible imaging agents plays a crucial role. Given the unique...
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Recent Advances of Organic Near-Infrared II Fluorophores in Optical Properties and Imaging Functions
Near-infrared (NIR) fluorescence imaging (FI) has become a research hotspot because of its distinctive imaging properties: high temporal resolution...
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Comparison of Near-Infrared Imaging Agents Targeting the PTPmu Tumor Biomarker
PurposeMaximal, safe resection of solid tumors is considered a critical first step in successful cancer treatment. The advent of fluorescence...
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Fluorescence imaging in colorectal surgery
BackgroundFluorescent imaging is an emerging technological tool that can guide surgeons during surgery by highlighting anatomical structures and...
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Current and Developing Lymphatic Imaging Approaches for Elucidation of Functional Mechanisms and Disease Progression
Study of the lymphatic system, compared to that of the other body systems, has been historically neglected. While scientists and clinicians have, in...
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Non-invasive molecular imaging for precision diagnosis of metastatic lymph nodes: opportunities from preclinical to clinical applications
Lymph node metastasis is an indicator of the invasiveness and aggressiveness of cancer. It is a vital prognostic factor in clinical staging of the...
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Molecular image–guided surgery in gynaecological cancer: where do we stand?
PurposeThe aim of this review is to give an overview of the current status of molecular image–guided surgery in gynaecological malignancies, from...
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The Efficacy and Safety of an Indocyanine Green-Macroaggregated Albumin-Hyaluronic Acid Mixture (LuminoMark™) for Surgical Localization of Recurrent Thyroid Cancer
BackgroundThe recurrence of thyroid cancer poses challenges compounded by postoperative fibrosis and anatomic changes. By overcoming the limitations...
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Enhanced Photodynamic Therapy by Improved Light Energy Capture Efficiency of Porphyrin Photosensitizers
Photodynamic therapy (PDT) has garnered increasing attention in cancer treatment because of its advantages such as minimal invasiveness and...
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Synergistic effect of mesoporous silica nanocarrier-assisted photodynamic therapy and anticancer agent activity on lung cancer cells
Investigating combined treatment methodologies is crucial for addressing the complex nature of cancer. As an emerging strategy, nano-biotechnology...