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Melatonin in infants—physiology, pathophysiology and intervention options
The effectiveness of melatonin in nonorganic sleep disorders in children and adolescents has been examined in 33 randomised controlled studies [
1 ]....
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Prophylactic effect of exogenous melatonin and melatonin receptor agonists on postoperative delirium in elderly patients: a systemic review and meta-analysis of randomized controlled trials
BackgroundThe prophylactic effect of exogenous melatonin and melatonin receptor agonists (MMRAs) on postoperative delirium (POD) in elderly patients...
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Melatonin bei Schlafstörungen im Kindes- und Jugendalter
State of researchTo date 33 randomized controlled trials (RCT) of varying quality on the effects of oral melatonin administration in comparison to...
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Lower plasma melatonin levels in non-hypoxic premature newborns associated with neonatal pain
We analyzed plasma melatonin levels in different groups of preterm newborns without hypoxia and their relationship with several perinatal variables...
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New Perspectives on the Role and Therapeutic Potential of Melatonin in Cardiovascular Diseases
Cardiovascular diseases (CVDs) are the leading cause of death and disability worldwide. It is essential to develop novel interventions to...
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Is melatonin as an ergogenic hormone a myth? a systematic review and meta-analysis
PurposeMelatonin supplementation has been disclosed as an ergogenic substance. However, the effectiveness of melatonin supplementation in healthy...
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Peculiarities of melatonin levels in preterm infants
BackgroundMelatonin plays an important role in organism functioning, child growth, and development. Of particular importance is melatonin for preterm...
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Neuroprotective effects of maternal melatonin administration in early-onset placental insufficiency and fetal growth restriction
BackgroundEarly-onset fetal growth restriction (FGR) is associated with adverse outcomes. We hypothesised that maternal melatonin administration will...
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The dark side of apnea: altered 24-hour melatonin secretion in obstructive sleep apnea (OSAS) is disease severity dependent
PurposeMelatonin aids in the synchronization of the circadian rhythm to the external environment. Few studies have tried to elucidate the...
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Bioavailability of Oniria®, a Melatonin Prolonged-Release Formulation, Versus Immediate-Release Melatonin in Healthy Volunteers
BackgroundMelatonin is an endogenous substance which plays a key role in sleep induction by reducing sleep onset latency; it has been approved by the...
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Melatonin improves influenza virus infection-induced acute exacerbation of COPD by suppressing macrophage M1 polarization and apoptosis
BackgroundInfluenza A viruses (IAV) are extremely common respiratory viruses for the acute exacerbation of chronic obstructive pulmonary disease...
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Circadian rhythms of melatonin and its relationship with anhedonia in patients with mood disorders: a cross-sectional study
BackgroundMood disorders are strongly associated with melatonin disturbances. However, it is unclear whether there is a difference in melatonin...
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Assessment of serum level of melatonin in migraine: a case control study
BackgroundMigraine attacks are reported to be severe enough to affect daily living events and can affect different age groups including early...
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The association of melatonin use and hip fracture: a matched cohort study
SummaryBy using propensity-score matched cohorts, we compared the risk of incident hip fracture between melatonin initiators and hypnotic...
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Maternal melatonin levels and temporal dietary intake: results from MY-CARE cohort study
Chrononutrition emerges as a novel approach to promote circadian alignment and metabolic health by means of time-of-the-day dietary intake. However,...
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Effect of melatonin on developmental competence, mitochondrial distribution, and intensity of fresh and vitrified/thawed in vitro matured buffalo oocytes
Background: In livestock breeding, oocyte cryopreservation is crucial for preserving and transferring superior genetic traits. This study was...
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Melatonin or its analogs as premedication to prevent emergence agitation in children: a systematic review and meta-analysis
BackgroundEmergence agitation (EA) is a prevalent complication in children following general anesthesia. Several studies have assessed the...
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Impact of the supplementation of melatonin on oxidative stress marker and serum endothelin-1 in patients with metabolic syndrome
ObjectiveMetabolic syndrome (MetS) is characterized by the cluster of risk factors associated with diabetes and cardiovascular diseases. Given the...
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European expert guidance on management of sleep onset insomnia and melatonin use in typically developing children
Sleeping problems are prevalent among children and adolescents, often leading to frequent consultations with pediatricians. While...
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Evaluating the effectiveness of melatonin in reducing the risk of foot ulcers in diabetic patients
ObjectivesDiabetes and its complications, as a major health concern, are associated with morbidity and mortality around the world. One of these...
