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Leptin deficiency, a potential mechanism for impaired fetal lung development in uteroplacental insufficiency?
Uteroplacental insufficiency (UPI) is a major cause of fetal growth restriction (FGR). Leptin, an adipokine, has been shown to play a vital role in...
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Uteroplacental insufficiency decreases leptin expression and impairs lung development in growth-restricted newborn rats
BackgroundThe study aimed to analyze the effect of uteroplacental insufficiency (UPI) on leptin expression and lung development of intrauterine...
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Altered leptin level in autism spectrum disorder and meta-analysis of adipokines
BackgroundIncreasing evidence suggests that leptin is involved in the pathology of autism spectrum disorder (ASD). In this study, our objective was...
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Predictive and prognostic value of leptin status in asthma
Asthma is closely associated with inflammation. We evaluated the predictive and prognostic value of leptin status in asthma. We searched the...
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PCSK9 and leptin plasma levels in anorexia nervosa
AimProprotein convertase subtilisin/kexin type 9 (PCSK9) is a regulator of low-density-lipoprotein cholesterol (LDL-C), a major risk factor for...
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Effect of acute and long-term exercise on leptin levels in depressed outpatients
BackgroundDepression is a leading cause of disability worldwide and a significant contributor to the global burden of disease. Altered leptin levels...
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Maturational effect of leptin on CO2 chemosensitivity in newborn rats
BackgroundLeptin augments central CO 2 chemosensitivity and stabilizes breathing in adults. Premature infants have unstable breathing and low leptin...
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Association between leptin and NAFLD: a two-sample Mendelian randomization study
BackgroundThe etiology of nonalcoholic fatty liver disease (NAFLD) involves a complex interaction of genetic and environmental factors. Previous...
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The interaction between rs 3,807,992 genotypes with the dietary inflammatory index on Leptin, Leptin resistance, and Galectin 3 in obese and overweight women
ObjectiveObesity is related to increasing leptin and some inflammatory factors that are associated with low-grade inflammation. Moreover, several...
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Impact of leptin or melatonin on Sema4D overexpression-related bone metabolism
PurposeThe current study aims to investigate the regulatory impact of leptin or melatonin on bone metabolism as well as the underlying mechanism in...
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Calorie restriction-induced leptin reduction and T-lymphocyte activation in blood and adipose tissue in men with overweight and obesity
BackgroundT-Lymphocyte activation is modulated by the adipokine leptin and serum concentrations of this hormone can be reduced with short-term...
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Association of Leptin with Glucose Intolerance and Gestational Diabetes Mellitus in Pregnant Women: Prospective Analytical Case–Control Study
This study aimed to investigate the use of leptin as a marker for gestational diabetes by analyzing any correlation between serum leptin levels...
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Leptin and ghrelin dynamics: unraveling their influence on food intake, energy balance, and the pathophysiology of type 2 diabetes mellitus
PurposeType 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance and impaired glucose homeostasis. In...
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Elevated serum leptin may be associated with disease activity and secondary osteoporosis in Chinese patients with rheumatoid arthritis
IntroductionRheumatoid arthritis (RA) is a systemic chronic autoimmune disease in adults that is associated with significant joint issues and...
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Associations between chronic widespread pain, pressure pain thresholds, leptin, and metabolic factors in individuals with knee pain
ObjectiveThe aim was to study associations between chronic widespread pain, widespread pain sensitivity, leptin, and metabolic factors in individuals...
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Musical therapy attenuates neuroma pain by modifying leptin expression
BackgroundAccumulating evidence reveals that music therapy appears to help patients with pain. However, there is a limited understanding of the...
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Effect of C-reactive protein deficiency on insulin resistance reversal in rats with polycystic ovary syndrome through augmented leptin action
BackgroundC-reactive protein(CRP), is an inflammatory marker that weaken leptin bioavailability and insulin sensitivity to disturb energy and glucose...
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Leptin receptor deficiency impedes metabolic surgery related-weight loss through inhibition of energy expenditure in db/db mice
BackgroundRoux-en-Y gastric bypass (RYGB) surgery is an effective metabolic surgery against diabetes and obesity. Clinical evidence indicates that...
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Correlation analysis between polymorphism of leptin and IGFI genes and body measurements in Barki and Farafra sheep
BackgroundGrowth performance, which can be evaluated using various body measurements, is crucial for providing red meat for human consumption. This...
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Relationship between leptin and white blood cells: a potential role in infection susceptibility and severity—the Olivetti Heart Study
A number of evidence showed an emerging role of leptin on immune system, involving inflammation, and innate and adaptive immunity. Few observational...
