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The insulin secretory granule is a hotspot for autoantigen formation in type 1 diabetes
In type 1 diabetes, the insulin-producing beta cells of the pancreas are destroyed through the activity of autoreactive T cells. In addition to...
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Secretory granule exocytosis and its amplification by cAMP in pancreatic β-cells
The sequence of events for secreting insulin in response to glucose in pancreatic β-cells is termed “ stimulus-secretion coupling ”. The core of...
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Association between protein undernutrition and diabetes: Molecular implications in the reduction of insulin secretion
Undernutrition is still a recurring nutritional problem in low and middle-income countries. It is directly associated with the social and economic...
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Presence of immunogenic alternatively spliced insulin gene product in human pancreatic delta cells
Aims/hypothesisTranscriptome analyses revealed insulin-gene-derived transcripts in non-beta endocrine islet cells. We studied alternative splicing of...
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Metabolism-secretion coupling in glucose-stimulated insulin secretion
Pancreatic β-cells in the islets of Langerhans secrete insulin in response to blood glucose levels. Precise control of the amount of insulin secreted...
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Capillary contact points determine beta cell polarity, control secretion and are disrupted in the db/db mouse model of diabetes
Aims/hypothesisAlmost all beta cells contact one capillary and insulin granule fusion is targeted to this region. However, there are reports of beta...
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Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression
Aims/hypothesisGenome-wide studies have uncovered multiple independent signals at the RREB1 locus associated with altered type 2 diabetes risk and...
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The role of insulin and incretin-based drugs in biliary tract cancer: epidemiological and experimental evidence
Insulin and incretin-based drugs are important antidiabetic agents with complex effects on cell growth and metabolism. Emerging evidence shows that...
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Prolonged culture of human pancreatic islets under glucotoxic conditions changes their acute beta cell calcium and insulin secretion glucose response curves from sigmoid to bell-shaped
Aims/hypothesisThe rapid remission of type 2 diabetes by a diet very low in energy correlates with a marked improvement in glucose-stimulated insulin...
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Insulin-like growth factor 1 receptor inhibits the proliferation of acute myeloid leukaemia cells via NK cell activation
Acute myeloid leukaemia (AML) denotes a heterogeneous category of cancers occurring within the bone marrow that are initiated by the unrestricted...
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miR-25 and miR-92b regulate insulin biosynthesis and pancreatic β-cell apoptosis
PurposePancreatic β-cell failure is a central hallmark of the pathogenesis of diabetes mellitus; however, the molecular basis underlying chronic...
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Opposing effects on regulated insulin secretion of acute vs chronic stimulation of AMP-activated protein kinase
Aims/hypothesisAlthough targeted in extrapancreatic tissues by several drugs used to treat type 2 diabetes, the role of AMP-activated protein kinase...
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Efficacy and safety of Jian-Pi Huo-Xue granule for non-alcoholic fatty liver disease: study protocol for a randomized, double-blind, placebo-controlled trial
BackgroundNon-alcoholic fatty liver disease (NAFLD) has become the most prevalent form of chronic liver disease, with a global prevalence of 25%...
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Progressive endoplasmic reticulum stress over time due to human insulin gene mutation contributes to pancreatic beta cell dysfunction
Aims/hypothesisWe studied the effects of heterozygous human INS gene mutations on insulin secretion, endoplasmic reticulum (ER) stress and other...
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A distinct transcriptional signature of antidepressant response in hippocampal dentate gyrus granule cells
Major depressive disorder is the most prevalent mental illness worldwide, still its pharmacological treatment is limited by various challenges, such...
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Mechanism of insulin resistance in obesity: a role of ATP
Obesity increases the risk of type 2 diabetes through the induction of insulin resistance. The mechanism of insulin resistance has been extensively...
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GLP-1 metabolite GLP-1(9–36) is a systemic inhibitor of mouse and human pancreatic islet glucagon secretion
Aims/hypothesisDiabetes mellitus is associated with impaired insulin secretion, often aggravated by oversecretion of glucagon. Therapeutic...
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Felix dies natalis, insulin… ceterum autem censeo “beta is better”
One hundred years after its discovery, insulin remains the life-saving therapy for many patients with diabetes. It has been a 100-years-old success...
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The making of insulin in health and disease
The discovery of insulin in 1921 has been one of greatest scientific achievements of the 20th century. Since then, the availability of insulin has...
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RFX6 haploinsufficiency predisposes to diabetes through impaired beta cell function
Aims/hypothesisRegulatory factor X 6 (RFX6) is crucial for pancreatic endocrine development and differentiation. The RFX6 variant p.His293LeufsTer7...
