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mRNA vaccine boosters and impaired immune system response in immune compromised individuals: a narrative review
Over the last 24 months, there has been growing evidence of a correlation between mRNA COVID-19 vaccine boosters and increased prevalence of COVID-19...
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The maternal gut microbiome in pregnancy: implications for the developing immune system
The gut microbiome has important roles in host metabolism and immunity, and microbial dysbiosis affects human physiology and health. Maternal...
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Targeting the innate immune system in pediatric and adult AML
While the introduction of T cell-based immunotherapies has improved outcomes in many cancer types, the development of immunotherapies for both adult...
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Immune cells: potential carriers or agents for drug delivery to the central nervous system
Drug delivery systems (DDS) have recently emerged as a promising approach for the unique advantages of drug protection and targeted delivery....
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Melittin as a safe compound to BALB/c mice immune system; a tiered approach immunotoxicity screening
BackgroundMaintenance of immune system integrity is a vital requirement to protect human body against pathogens/cancers. Natural compounds have long...
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No association between blood-based markers of immune system and migraine status: a population-based cohort study
BackgroundAlthough some evidence implicates the immune system in migraine attacks, its role during attack-free periods remains largely unexplored....
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A novel immune checkpoint score system for prognostic evaluation in pancreatic adenocarcinoma
BackgroundPancreatic adenocarcinoma (PAAD) remains a lethal malignancy making the detection of novel prognostic biomarkers urgent. Limited studies...
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Vitamin D, the immune system, and its relationship with diseases
BackgroundVitamin D is classified as an immunomodulatory hormone that is synthesized because of skin exposure to sunlight. It is known to come into...
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Impact of progesterone on the immune system in women: a systematic literature review
PurposeThe immune system is influenced by many factors, including female sex hormones. The extent of this influence, however, is not completely...
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The mutual relationship between the host immune system and radiotherapy: stimulating the action of immune cells by irradiation
The effects of irradiation on tumor tissue and the host immune system are interrelated. The antitumor effect of irradiation is attenuated in the...
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Functionalized chitosan-G-poly caprolactone vaccine delivery system fabricated to display antigen–antibody immune complexes of Mycobacterium tuberculosis elicits immune response in Ex-vivo model
BackgroundVaccine development against tuberculosis remains a global health imperative, necessitating robust immunogenicity and safety profiles....
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The role of the immune system in posttraumatic stress disorder
Posttraumatic stress disorder (PTSD) develops in a subset of individuals upon exposure to traumatic stress. In addition to well-defined psychological...
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A mammalian lung's immune system minimizes tissue damage by initiating five major sequential phases of defense
The mammalian lungs encounter several pathogens, but have a sophisticated multi-phase immune defense. Furthermore, several immune responses to...
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Why does the immune system destroy pancreatic β-cells but not α-cells in type 1 diabetes?
A perplexing feature of type 1 diabetes (T1D) is that the immune system destroys pancreatic β-cells but not neighbouring α-cells, even though both...
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Building digital twins of the human immune system: toward a roadmap
Digital twins, customized simulation models pioneered in industry, are beginning to be deployed in medicine and healthcare, with some major...
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The immune system as a driver of mitochondrial disease pathogenesis: a review of evidence
BackgroundGenetic mitochondrial diseases represent a significant challenge to human health. These diseases are extraordinarily heterogeneous in...
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Peripheral nervous system adverse events associated with immune checkpoint inhibitors
BackgroundImmune checkpoint inhibitors (ICIs) represent an effective cancer immunotherapy yet are associated with immune-related adverse events...
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The impact of different training intensities on athletes' immune system function and the management of upper respiratory traction infections: a narrative review
Athletes employ high-intensity training to promote their physical fitness. However, high-intensity training can harm the immune system, making...
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Defects of the Innate Immune System and Related Immune Deficiencies
The innate immune system is the host’s first line of defense against pathogens. Toll-like receptors (TLRs) are pattern recognition receptors that...
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Cognitive impairments correlate with increased central nervous system immune activation after allogeneic haematopoietic stem cell transplantation
Murine studies indicate that, after allogeneic haematopoietic stem cell transplantation (aHSCT), donor-derived macrophages replace damaged microglia...
