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Association of IL-4 (− 590 C/T) and IL-6 (− 174 G/C) gene polymorphism in South Indian CKD patients
AimThe present study was undertaken to examine the role of IL-4 (− 590 C/T) (rs2243250) and IL-6 (− 174G/C) (rs1800795) polymorphism and the serum...
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PCR-positive meningococcal CSF infection without pleocytosis but high IL-6 and IL-8
BackgroundMeningococcal meningitis is still a severe disease causing high mortality and morbidity rates. Early diagnosis is crucial to ensure prompt...
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Assessment of selected interleukins (IL-6, IL-17A, IL-18, IL-23) and chemokines (RANTES, IP-10) in children with acute and chronic urticaria
BackgroundUrticarial lesions develop as a result of the activation of mast cells which, through the release of mediators, influence the formation of...
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Serum concentrations of proinflammatory biomarker interleukin-6 (IL-6) as a predictor of postoperative complications after elective colorectal surgery
BackgroundThe aim of this prospective study was to evaluate the role of serum IL-6 as a potential predictive biomarker of postoperative complications...
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The double-edged effects of IL-6 in liver regeneration, aging, inflammation, and diseases
Interleukin-6 (IL-6) is a pleiotropic cytokine and exerts its complex biological functions mainly through three different signal modes, called cis- , trans-...
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P. gingivalis in oral-prostate axis exacerbates benign prostatic hyperplasia via IL-6/IL-6R pathway
BackgroundBenign prostatic hyperplasia (BPH) is the most common disease in elderly men. There is increasing evidence that periodontitis increases the...
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Cytokine storm and translating IL-6 biology into effective treatments for COVID-19
As of May 3, 2023, the Coronavirus disease 2019 (COVID-19) pandemic has resulted in more than 760 million confirmed cases and over 6.9 million...
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The involvement of RIPK4 in TNF-α-stimulated IL-6 and IL-8 production by melanoma cells
PurposeThe receptor-interacting protein kinase (RIPK4) has an oncogenic function in melanoma, regulates NF-κB and Wnt/β-catenin pathways, and is...
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Association between psychiatric admissions in patients with schizophrenia and IL-6 plasma levels polygenic score
Schizophrenia diagnosis and admission history were associated with a polygenic score (PGS) for schizophrenia based on a subset of variants that act...
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MMP1, IL-1β, sTNFR-1, and IL-6 are prognostic factors for patients with unresectable or metastatic renal cell carcinoma treated with immune checkpoint inhibitors
BackgroundFew studies have reported reliable prognostic factors for immune checkpoint inhibitors (ICIs) in renal cell carcinoma (RCC). Therefore, we...
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Mitochondrial DNA is a key driver in cigarette smoke extract-induced IL-6 expression
Smoking is an independent risk factor for atherosclerosis, the primary pathogenesis of which is inflammation. We recently reported that cigarette...
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Serum Sirt6 as a Potential Biomarker for Osteoarthritis and its Correlation with IL-6 Alterations
ObjectiveThe study aimed to assess Sirt6 levels in serum of knee osteoarthritis (OA) patients compared to healthy individuals to evaluate its...
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Elevated serum IFN-γand IFN-γ/IL-6 ratio in Kikuchi-Fujimoto disease
BackgroundKikuchi-Fujimoto disease (KFD) is typically a benign, self-limiting inflammatory disease. The diagnosis of KFD can be challenging for...
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Paradoxical effect of anti-inflammatory drugs on IL-6 mRNA expression in patients with PTSD during treatment
The pathophysiology of posttraumatic stress disorder (PTSD) is associated with the activation of the innate immune system, including cytokines like...
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An epithelial gene signature of trans-IL-6 signaling defines a subgroup of type 2-low asthma
BackgroundAsthma is stratified into type 2-high and type 2-low inflammatory phenotypes. Limited success has been achieved in developing drugs that...
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IL-6 induces periostin production in human ACL remnants: a possible mechanism causing post-traumatic osteoarthritis
ObjectivePerostin (POSTN) and IL-6 consistently elevated after ACL injury, and ACL has been proposed as the major source of POSTN. However, there is...
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Diagnostic value of IL-6 for patients with asthma: a meta-analysis
BackgroundIL-6 is a pleotropic cytokine that acts as a pro-inflammatory mediator and acute-phase response inducer, but has also been reported to...
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Associations between IL-1α, IL-1β, TNFα, and IL-6 variations, and susceptibility to transposition of the great arteries
BackgroundTo evaluate the relationship between IL-1α -889C/T (rs1800587), IL-1β -511C > T (rs16944), TNFα -308G > A (rs1800629), TNFα -238G > A...
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IL-6 Levels Correlate with Prognosis and Immunosuppressive Stromal Cells in Patients with Colorectal Cancer
BackgroundThe prognosis for patients with colorectal cancer (CRC) is determined by tumor characteristics as well as the host immune response. This...
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Serum IL-6 as a Surrogate Biomarker of Post-operative Complications in Invasive Orthopaedic Surgeries: A Prospective Observational Study
BackgroundInterleukin-6 (IL-6) is a cytokine released in response to tissue injury. Elevated serum IL-6 levels in trauma patients have been linked...
