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Frontal deficits and atrophy in a patient with familial encephalopathy with neuroserpin inclusion bodies detected by single-case voxel-based morphometry: a case report
BackgroundFamilial encephalopathy with neuroserpin inclusion bodies (FENIB) is a rare genetic disorder characterized by progressive cognitive decline...
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Clinical characteristics and potential association to Parkinson’s disease and dementia with Lewy bodies in patients with major depressive disorder who received maintenance electroconvulsive therapy: a retrospective chart review study
BackgroundMaintaining remission after electroconvulsive therapy (ECT) is clinically relevant in patients with depression, and maintenance ECT has...
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The enigma of depression in corticobasal degeneration, a frequent but poorly understood co-morbidity
Depression is one of the most frequent neuropsychiatric symptoms in corticobasal degeneration (CBD), a rare, sporadic, and late-onset progressive...
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Pathomechanisms of cognitive and behavioral impairment in corticobasal degeneration
Corticobasal degeneration (CBD) is a rare, sporadic, late-onset progressive neurodegenerative disorder of unknown etiology, clinically characterized...
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Flanagan’s condensed protocol for neurodegenerative diseases. Implementation in a clinical autopsy setting with partial supervision of a neuropathologist
The Condensed Protocol (CP) was originally developed for the evaluation of Alzheimer’s Disease (AD) and other neurodegenerative diseases as a...
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Endemic parkinsonism: clusters, biology and clinical features
The term ‘endemic parkinsonism’ refers to diseases that manifest with a dominant parkinsonian syndrome, which can be typical or atypical, and are...
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A comparative study of short-term phonatory outcomes in primary cases of early glottic cancer treated with radiotherapy versus laser surgery
BackgroundEarly-stage glottic carcinomas can be treated with either laser surgery or radiotherapy. Both approaches have demonstrated similar cure...
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The necroptosis cell death pathway drives neurodegeneration in Alzheimer’s disease
Although apoptosis, pyroptosis, and ferroptosis have been implicated in AD, none fully explains the extensive neuronal loss observed in AD brains....
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Identification of retinal oligomeric, citrullinated, and other tau isoforms in early and advanced AD and relations to disease status
This study investigates various pathological tau isoforms in the retina of individuals with early and advanced Alzheimer’s disease (AD), exploring...
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Cortical threaded pedicle screw improves fatigue strength in decreased bone quality
PurposeInadequate anchoring of pedicle screws in vertebrae with poor bone quality is a major problem in spine surgery. The aim was to evaluate...
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Usage of cadavers in surgical training and research in Japan over the past decade
The “Guidelines for Cadaver Dissection in Education and Research of Clinical Medicine” drafted by the Japan Surgical Society (JSS) and the Japanese...
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An unexpected sudden death due to a choroid plexus papilloma: an autopsy case report
BackgroundChoroid plexus papillomas (CPPs) are histopathologically benign and rare central nervous system tumors. These tumors remain more frequent...
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New and Evolving Treatments for Neurologic Dysphagia
Despite swallowing being a frequently performed daily function, it is highly complex. For a safe swallow to occur, muscles within the head, neck, and...
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Loss of TDP-43 splicing repression occurs early in the aging population and is associated with Alzheimer’s disease neuropathologic changes and cognitive decline
LATE-NC, the neuropathologic changes of limbic-predominant age-related TAR DNA-binding protein 43 kDa (TDP-43) encephalopathy are frequently...
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Mechanisms and clinical management of eosinophilic oesophagitis: an overview
Since the first description of eosinophilic oesophagitis (EoE) less than three decades ago, we have observed a striking increase in the number of...
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Synaptic configuration and reconfiguration in the neocortex are spatiotemporally selective
Brain computation relies on the neural networks. Neurons extend the neurites such as dendrites and axons, and the contacts of these neurites that...
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Histopathologic brain age estimation via multiple instance learning
Understanding age acceleration, the discordance between biological and chronological age, in the brain can reveal mechanistic insights into normal...
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Hepatocellular carcinoma with regional lymphadenopathy caused by sarcoid-like reaction: a case report
BackgroundSarcoid-like reaction (SLR) is a histological pattern of granulomatous inflammation that is clinically differentiated from sarcoidosis....
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Retinal pathological features and proteome signatures of Alzheimer’s disease
Alzheimer’s disease (AD) pathologies were discovered in the accessible neurosensory retina. However, their exact nature and topographical...
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The Guillain-Mollaret triangle: a key player in motor coordination and control with implications for neurological disorders
The dentato-rubro-olivary pathway, also known as the Guillain-Mollaret triangle (GMT) or myoclonic triangle, consists of the dentate nucleus, the red...
