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Regional hippocampal atrophy reflects memory impairment in patients with early relapsing remitting multiple sclerosis
BackgroundResearch work has shown that hippocampal subfields are atrophic to varying extents in multiple sclerosis (MS) patients. However, studies...
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Prognostic value of scalp EEG ictal patterns in epilepsy surgery of hippocampal sclerosis
BackgroundTemporal lobe epilepsy associated with hippocampal sclerosis (TLE-HS) is a surgically treatable epileptic syndrome. While the core of...
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Repetitive head impacts and chronic traumatic encephalopathy are associated with TDP-43 inclusions and hippocampal sclerosis
Hippocampal sclerosis (HS) is associated with advanced age as well as transactive response DNA-binding protein with 43 kDa (TDP-43) deposits. Both...
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Clinical Evaluation of a Quantitative Imaging Biomarker Supporting Radiological Assessment of Hippocampal Sclerosis
Objective:To evaluate the influence of quantitative reports (QReports) on the radiological assessment of hippocampal sclerosis (HS) from MRI of...
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Acute symptomatic seizures and hippocampal sclerosis: the major contributor for post-stroke epilepsy?
ObjectiveHippocampal sclerosis (HS) is a prominent biomarker of epilepsy. If acquired later in life, it usually occurs in the context of degenerative...
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Hippocampal sclerosis is associated with celiac disease type immunity in patients with drug-resistant temporal lobe epilepsy
BackgroundA prior small-scale single center study suggested an association between celiac disease (CD)-type immunity and refractory temporal lobe...
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Characterization of hippocampal sclerosis of aging and its association with other neuropathologic changes and cognitive deficits in the oldest-old
Hippocampal sclerosis of aging (HS-A) is a common age-related neuropathological lesion characterized by neuronal loss and astrogliosis in subiculum...
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Early identification of seizure freedom with medical treatment in patients with mesial temporal lobe epilepsy and hippocampal sclerosis
BackgroundMesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) is usually associated with a poor response to antiseizure medications....
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Effect of BDNF Val66Met polymorphism on hippocampal subfields in multiple sclerosis patients
Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism was shown to strongly affect BDNF function, but its role in modulating gray matter...
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Regulation of Keap1-Nrf2 axis in temporal lobe epilepsy—hippocampal sclerosis patients may limit the seizure outcomes
BackgroundAccumulation of reactive oxygen species (ROS) exacerbates neuronal loss during seizure-induced excitotoxicity. Keap1 (Kelch-like...
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Memory-guided navigation in amyotrophic lateral sclerosis
BackgroundPrevious studies have yielded inconsistent results about hippocampal involvement in non-demented patients with amyotrophic lateral...
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Reduced myelin in patients with isolated hippocampal sclerosis as assessed by SyMRI
PurposeSynthetic MRI (SyMRI) enables to quantify brain tissue and morphometry. We aimed to investigate the WM and myelin alterations in patients with...
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Hippocampal sclerosis and epilepsy surgery in neurofibromatosis type 1: case report of a 3-year-old child explored by SEEG and review of the literature
PurposeEpilepsy associated with neurofibromatosis type 1 (NF1) is infrequent and usually controlled with anti-epileptic drugs. However, in some...
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Cognitive impairment in multiple sclerosis: from phenomenology to neurobiological mechanisms
Multiple sclerosis (MS) is an autoimmune-mediated disease of the central nervous system characterized by inflammation, demyelination and chronic...
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Volumetric hippocampal changes in glioblastoma: a biomarker for neuroplasticity?
PurposeThe pleiotropic effect of gliomas on the development of cognitive disorders and structural brain changes has garnered increasing interest in...
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Matrix metalloproteinase 9 (MMP-9) activity, hippocampal extracellular free water, and cognitive deficits are associated with each other in early phase psychosis
Increasing evidence points toward the role of the extracellular matrix, specifically matrix metalloproteinase 9 (MMP-9), in the pathophysiology of...
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Resting state functional connectivity modifications in monoaminergic circuits underpin fatigue development in patients with multiple sclerosis
Dysregulation of monoaminergic networks might have a role in the pathogenesis of fatigue in multiple sclerosis (MS). We investigated longitudinal...
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Abnormal thalamic functional connectivity correlates with cardiorespiratory fitness and physical activity in progressive multiple sclerosis
BackgroundAltered thalamic volumes and resting state (RS) functional connectivity (FC) might be associated with physical activity (PA) and...
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Hippocampal sclerosis without visually detectable hippocampal MRI abnormalities: automated subfield volumetric analysis
PurposeThis study aims to investigate hippocampal subfield volumes in patients with hippocampal sclerosis (HS) without visually detectable MRI...
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Baroreflex sensitivity is associated with markers of hippocampal gliosis and dysmyelination in patients with psychosis
PurposeHippocampal dysfunction plays a key role in the pathology of psychosis. Given hippocampal sensitivity to changes in cerebral perfusion,...
