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The proteome of granulovacuolar degeneration and neurofibrillary tangles in Alzheimer’s disease
Granulovacuolar degeneration (GVD) is a common feature in Alzheimer’s disease (AD). The occurrence of GVD is closely associated with that of...
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The necroptosis cell death pathway drives neurodegeneration in Alzheimer’s disease
Although apoptosis, pyroptosis, and ferroptosis have been implicated in AD, none fully explains the extensive neuronal loss observed in AD brains....
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Necrosome complex detected in granulovacuolar degeneration is associated with neuronal loss in Alzheimer’s disease
Alzheimer’s disease (AD) is characterized by a specific pattern of neuropathological changes, including extracellular amyloid β (Aβ) deposits,...
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Frontotemporal lobar degeneration with TAR DNA-binding protein 43 (TDP-43): its journey of more than 100 years
Frontotemporal lobar degeneration (FTLD) with TDP-43-immunoreactive inclusions (FTLD–TDP) is a neurodegenerative disease associated with clinical,...
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Increased prevalence of granulovacuolar degeneration in C9orf72 mutation
Granulovacuolar degeneration (GVD) is usually found in Alzheimer’s disease (AD) cases or in elderly individuals. Its severity correlates positively...
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Granulovacuolar degeneration bodies are neuron-selective lysosomal structures induced by intracellular tau pathology
Granulovacuolar degeneration bodies (GVBs) are membrane-bound vacuolar structures harboring a dense core that accumulate in the brains of patients...
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Friend or foe: role of pathological tau in neuronal death
Neuronal death is one of the most common pathological hallmarks of diverse neurological diseases, which manifest varying degrees of cognitive or...
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LATE-NC staging in routine neuropathologic diagnosis: an update
An international consensus report in 2019 recommended a classification system for limbic-predominant age-related TDP-43 encephalopathy...
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Nucleus Pulposus Cells from Calcified Discs Promote the Degradation of the Extracellular Matrix through Upregulation of the GATA3 Expression
ObjectiveDisc calcification is strongly associated with disc degeneration; however, the underlying mechanisms driving its pathogenesis are poorly...
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Flanagan’s condensed protocol for neurodegenerative diseases. Implementation in a clinical autopsy setting with partial supervision of a neuropathologist
The Condensed Protocol (CP) was originally developed for the evaluation of Alzheimer’s Disease (AD) and other neurodegenerative diseases as a...
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The clinical importance of suspected non-Alzheimer disease pathophysiology
The development of biomarkers for Alzheimer disease (AD) has led to the origin of suspected non-AD pathophysiology (SNAP) — a heterogeneous...
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Qihuang Granule protects the retinal pigment epithelium from oxidative stress via regulation of the alternative complement pathway
BackgroundAge-related macular degeneration (AMD) is a leading cause of vision loss in elderly people, and dry AMD is the most common type of AMD....
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Regulated cell death and its role in Alzheimer’s disease and amyotrophic lateral sclerosis
Despite considerable research efforts, it is still not clear which mechanisms underlie neuronal cell death in neurodegenerative diseases. During the...
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Alzheimer disease neuropathology in a patient previously treated with aducanumab
Amyloid beta (Aβ) plaque is a defining pathologic feature of Alzheimer disease (AD). Aducanumab, a monoclonal IgG1 that selectively binds aggregated...
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Brain FDG-PET correlates of saccadic disorders in early PSP
BackgroundNew diagnostic criteria of Progressive Supranuclear Palsy (PSP) have highlighted the interest of Eye Movement Records (EMR) at the early...
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Identification of retinal oligomeric, citrullinated, and other tau isoforms in early and advanced AD and relations to disease status
This study investigates various pathological tau isoforms in the retina of individuals with early and advanced Alzheimer’s disease (AD), exploring...
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Hippocampal subfield volumetry in corticobasal syndrome of diverse underlying pathologies
IntroductionMultiple pathologies may underlie corticobasal syndrome (CBS), including Alzheimer’s disease (AD). Typical amnestic AD is characterized...
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Retinal pathological features and proteome signatures of Alzheimer’s disease
Alzheimer’s disease (AD) pathologies were discovered in the accessible neurosensory retina. However, their exact nature and topographical...
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Mutation ∆K281 in MAPT causes Pick’s disease
Two siblings with deletion mutation ∆K281 in MAPT developed frontotemporal dementia. At autopsy, numerous inclusions of hyperphosphorylated 3R Tau...
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Glycogen Synthase Kinase-3β, NLRP3 Inflammasome, and Alzheimer’s Disease
Alzheimer’s disease (AD) is the most prevalent cause of dementia worldwide. Because of the progressive neurodegeneration, individual cognitive and...
