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“De novo replication repair deficient glioblastoma, IDH-wildtype” is a distinct glioblastoma subtype in adults that may benefit from immune checkpoint blockade
Glioblastoma is a clinically and molecularly heterogeneous disease, and new predictive biomarkers are needed to identify those patients most likely...
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Extracellular vesicles in glioblastoma: a challenge and an opportunity
Glioblastoma is a highly heterogeneous tumor whose pathophysiological complexities dictate both the diagnosis of disease severity as well as response...
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Spinal and cervical nodal metastases in a patient with glioblastoma
This article presents the rare case of a 54-year-old gentleman with primary glioblastoma developing multiple extracranial metastases 7 months after...
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Surgical site infections after glioblastoma surgery: boon or bane?
BackgroundSurgical site infections (SSIs) are among the most common postoperative complications. Glioblastoma multiforme is the most frequent...
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Beyond fluorescence-guided resection: 5-ALA-based glioblastoma therapies
Glioblastoma is the most common primary malignant brain tumor. Despite advances in multimodal concepts over the last decades, prognosis remains poor....
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Resolving spatial response heterogeneity in glioblastoma
PurposeSpatial intratumoral heterogeneity poses a significant challenge for accurate response assessment in glioblastoma. Multimodal imaging coupled...
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Novel Clinical Trials and Approaches in the Management of Glioblastoma
Purpose of ReviewThe purpose of this review is to discuss a wide variety of novel therapies recently studied or actively undergoing study in patients...
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Glioblastoma: a comprehensive approach combining bibliometric analysis, Latent Dirichlet Allocation, and HJ-Biplot
Glioblastoma is a common and aggressive malignant central nervous system tumor in adults. This study aims to evaluate and analyze the scientific...
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Androgen deficiency is associated with a better prognosis in glioblastoma
BackgroundThe androgen receptor (AR) has been demonstrated to play a role in the pathogenesis of glioblastoma; however, the implications of...
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Postoperative disappearance of leptomeningeal enhancement around the brainstem in glioblastoma
PurposeLeptomeningeal enhancement (LME) suggests leptomeningeal dissemination (LMD) of tumor cells, which is a complication of end-stage...
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Prognostic values and immune infiltration of KLF15, AQP7, AGPAT9 in glioma and glioblastoma
BackgroundsThe overall survival of patients with lower-grade gliomas and glioblastoma varies greatly. No reliable or existing procedures can...
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Disease Assessments in Patients with Glioblastoma
Purpose of ReviewThe neuro-oncology team faces a unique challenge when assessing treatment response in patients diagnosed with glioblastoma. Magnetic...
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The effect of indicators of CALLY index on survival in glioblastoma
IntroductionGlioblastoma is the most common primary brain tumor in adults. Recently, research has been published on the potential prognostic...
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A peculiar case of pure intraventricular glioblastoma
Glioblastoma (formerly named glioblastoma multiforme) is the most common primary central nervous system tumor, representing 45% of all cases and 15%...
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Temporal change of DNA methylation subclasses between matched newly diagnosed and recurrent glioblastoma
The longitudinal transition of phenotypes is pivotal in glioblastoma treatment resistance and DNA methylation emerged as an important tool for...
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Molecular mechanisms of tumour development in glioblastoma: an emerging role for the circadian clock
Glioblastoma is one of the most lethal cancers with current therapeutic options lacking major successes. This underlines the necessity to understand...
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Low rCBV values in glioblastoma tumor progression under chemoradiotherapy
PurposeAfter standard treatment for glioblastoma, perfusion MRI remains challenging for differentiating tumor progression from post-treatment...
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Proapoptotic and proautophagy effect of H1-receptor antagonist desloratadine in human glioblastoma cell lines
Glioblastomas are aggressive and usually incurable high-grade gliomas without adequate treatment. In this study, we aimed to investigate the...
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Current approaches in glioblastoma multiforme immunotherapy
Glioblastoma multiform (GBM) is the most prevalent CNS (central nervous system) tumor in adults, with an average survival length shorter than 2 years...
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EZH2-Myc driven glioblastoma elicited by cytomegalovirus infection of human astrocytes
Mounting evidence is identifying human cytomegalovirus (HCMV) as a potential oncogenic virus. HCMV has been detected in malignant gliomas. EZH2 and...
