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Extreme behavioural and psychological symptoms of dementia: a case study
BackgroundThe seven tiered behavioural and psychological symptoms of dementia (BPSD) model of service delivery has been used by inpatient units. The...
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Extreme conditioning session augments brain-derived neurotrophic factor in healthy novice participants: a pilot study
PurposeTo analyze the circulating serum levels of the brain-derived neurotrophic factor (BDNF) in novice participants submitted to an extreme...
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Extreme deviations from the normative model reveal cortical heterogeneity and associations with negative symptom severity in first-episode psychosis from the OPTiMiSE and GAP studies
There is currently no quantifiable method to predict long-term clinical outcomes in patients presenting with a first episode of psychosis. A major...
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Potential biomarkers in hypoglycemic brain injury
Oxidative stress is a major underlying mechanism in hypoglycemic brain injury. Several oxidative stress–related proteins were identified through...
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A regional brain volume–based age prediction model for neonates and the derived brain maturation index
ObjectiveTo develop a postmenstrual age (PMA) prediction model based on segmentation volume and to evaluate the brain maturation index using the...
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A clinical guide to rare male sexual disorders
Conditions referred to as ‘male sexual dysfunctions’ usually include erectile dysfunction, ejaculatory disorders and male hypogonadism. However, some...
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Early neurodevelopmental outcomes of extreme preterm infants exposed to paracetamol: a retrospective cohort study
BackgroundParacetamol is commonly used for analgesia and patent ductus arteriosus (PDA) treatment in preterm infants. We aimed to evaluate early...
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A novel methylation signature predicts extreme long-term survival in glioblastoma
PurposeGlioblastoma (GBM) is the most common malignant primary brain tumor with a dismal prognosis of less than 2 years under maximal therapy....
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Clinical implications of brain asymmetries
No two human brains are alike, and with the rise of precision medicine in neurology, we are seeing an increased emphasis on understanding the...
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Fetal brain growth and infant autistic traits
BackgroundStructural differences exist in the brains of autistic individuals. To date only a few studies have explored the relationship between fetal...
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Language performance and brain volumes, asymmetry, and cortical thickness in children born extremely preterm
BackgroundChildren born preterm are more prone to have language difficulties. Few studies focus on children born extremely preterm (EPT) and the...
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The Optimal pressure reactivity index range is disease-specific: A comparison between aneurysmal subarachnoid hemorrhage and traumatic brain injury
PurposeImpaired cerebral pressure autoregulation is common and detrimental after acute brain injuries. Based on the prevalence of delayed cerebral...
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Clinical practice and effect of carbon dioxide on outcomes in mechanically ventilated acute brain-injured patients: a secondary analysis of the ENIO study
PurposeThe use of arterial partial pressure of carbon dioxide (PaCO 2 ) as a target intervention to manage elevated intracranial pressure (ICP) and...
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Acute subdural haematoma exacerbates cerebral blood flow disorder and promotes the development of intraoperative brain bulge in patients with severe traumatic brain injury
BackgroundDecompressive craniectomy (DC) is a routine procedure used for the treatment of severe traumatic brain injury (TBI) with concomitant acute...
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Role of transcranial Doppler in assessment of cerebral blood flow in full term neonates with extreme unconjugated hyperbilirubinemia
PurposeTo evaluate the difference in cerebral blood flow in neonates with and without extreme unconjugated hyperbilirubinemia.
Methods ...
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Brain frailty associated with stroke events in anterior circulation large artery occlusion
ObjectiveTo investigate the factors associated with brain frailty and the effect of brain frailty in patients with anterior circulation large artery...
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Carmustine wafer implantation for supratentorial glioblastomas, IDH-wildtype in “extreme” neurosurgical conditions
We assessed the feasibility of Carmustine wafer implantation in “extreme” conditions (i.e. patients > 80 years and Karnofsky Performance Status...
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Peripheral immunity and risk of incident brain disorders: a prospective cohort study of 161,968 participants
Whether peripheral immunity prospectively influences brain health remains controversial. This study aims to investigate the longitudinal associations...
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Activation of glucagon-like peptide-1 receptors reduces the acquisition of aggression-like behaviors in male mice
Aggression is a complex social behavior, which is provoked in the defense of limited resources including food and mates. Recent advances show that...
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The impact of placental genomic risk for schizophrenia and birth asphyxia on brain development
The placenta plays a role in fetal brain development, and pregnancy and birth complications can be signs of placental dysfunction. Birth asphyxia is...
