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NAPE-PLD in the ventral tegmental area regulates reward events, feeding and energy homeostasis
The N -acyl phosphatidylethanolamine-specific phospholipase D (NAPE-PLD) catalyzes the production of N -acylethanolamines (NAEs), a family of...
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ADGRL1 is a glucose receptor involved in mediating energy and glucose homeostasis
Aims/hypothesisThe brain is a major consumer of glucose as an energy source and regulates systemic glucose as well as energy balance. Although...
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Short-chain fatty acids are associated with adiposity, energy and glucose homeostasis among different metabolic phenotypes in the Nutritionists’ Health Study
Background and aimsThe gut microbiome is associated with obesity, mainly mediated by bacteria-produced short-chain fatty acids (SCFAs). It is unknown...
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Mitochondrial homeostasis: shaping health and disease
Mitochondria serve as the primary site for metabolizing the three major nutrients, underscoring their pivotal role in cellular energy metabolism and...
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The effects of ghrelin and LEAP-2 in energy homeostasis are modulated by thermoneutrality, high-fat diet and aging
PurposeLiver-expressed antimicrobial peptide 2 (LEAP-2) has been recently identified as the endogenous non-competitive allosteric antagonist of the...
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Interoceptive regulation of skeletal tissue homeostasis and repair
Recent studies have determined that the nervous system can sense and respond to signals from skeletal tissue, a process known as skeletal...
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Multifaceted actions of melanin-concentrating hormone on mammalian energy homeostasis
Melanin-concentrating hormone (MCH) is a small cyclic peptide expressed in all mammals, mainly in the hypothalamus. MCH acts as a robust integrator...
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Repercussion of inflammatory bowel disease on lung homeostasis: The role of photobiomodulation
Inflammatory bowel diseases (IBD) are chronic and multifactorial diseases characterized by dysfunction of the intestinal mucosa and impaired immune...
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The role of claudins in homeostasis
Sequential expression of claudins, a family of tight junction proteins, along the nephron mirrors the sequential expression of ion channels and...
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Homeostasis and dyshomeostasis of the retina
Retinal homeostasis is maintained through a network of the nervous, circulatory, endocrine and immune systems. The integrity of the blood-retinal...
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Adropin promotes testicular functions by modulating redox homeostasis in adult mouse
PurposeAdropin is an emerging metabolic hormone that has a role in regulating energy homeostasis. The present study aimed to explore the impact of...
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Small-molecule amines: a big role in the regulation of bone homeostasis
Numerous small-molecule amines (SMAs) play critical roles in maintaining bone homeostasis and promoting bone regeneration regardless of whether they...
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Sacubitril/valsartan ameliorates tubulointerstitial fibrosis by restoring mitochondrial homeostasis in diabetic kidney disease
BackgroundTubulointerstitial fibrosis plays an important role in the progression of diabetic kidney disease (DKD). Sacubitril/valsartan (Sac/Val)...
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Disorders of phosphate homeostasis in children, part 1: primer on mineral ion homeostasis and the roles of phosphate in skeletal biology
Phosphate has extensive physiological roles including energy metabolism, genetic function, signal transduction and membrane integrity. Regarding the...
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Differential effects of plant-based flours on metabolic homeostasis and the gut microbiota in high-fat fed rats
BackgroundThe gut microbiome is a salient contributor to the development of obesity, and diet is the greatest modifier of the gut microbiome, which...
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Physical frailty is related to oxidative stress through thiol/disulfide homeostasis parameters
AimTo evaluate relationship between frailty and oxidative stress through thiol/disulfide homeostasis parameters [Native thiol (NT), total thiol (TT),...
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Deciphering the role of zinc homeostasis in the tumor microenvironment and prognosis of prostate cancer
BackgroundDysregulation of zinc homeostasis is widely recognized as a hallmark feature of prostate cancer (PCa) based on the compelling clinical and...
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Redox homeostasis dysregulation in noise-induced hearing loss: oxidative stress and antioxidant treatment
Noise exposure is an important cause of acquired hearing loss. Studies have found that noise exposure causes dysregulated redox homeostasis in...
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DEAD-box helicase 17 (DDX17) protects cardiac function by promoting mitochondrial homeostasis in heart failure
DEAD-box helicase 17 (DDX17) is a typical member of the DEAD-box family with transcriptional cofactor activity. Although DDX17 is abundantly...
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Identification of an endocannabinoid gut-brain vagal mechanism controlling food reward and energy homeostasis
The regulation of food intake, a sine qua non requirement for survival, thoroughly shapes feeding and energy balance by integrating both homeostatic...
