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Enhanced cognitive flexibility and phasic striatal dopamine dynamics in a mouse model of low striatal tonic dopamine
The catecholamine neuromodulators dopamine and norepinephrine are implicated in motor function, motivation, and cognition. Although roles for...
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Dopamine transporter blockade during adolescence increases adult dopamine function, impulsivity, and aggression
Sensitive developmental periods shape neural circuits and enable adaptation. However, they also engender vulnerability to factors that can perturb...
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Brain connectivity changes to fast versus slow dopamine increases
The rewarding effects of stimulant drugs such as methylphenidate (MP) depend crucially on how fast they raise dopamine in the brain. Yet how the rate...
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Rethinking Parkinson's disease: could dopamine reduction therapy have clinical utility?
Following reports of low striatal dopamine content in Parkinson’s disease, levodopa was shown to rapidly reverse hypokinesis, establishing the model...
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Increasing dopamine synthesis in nigrostriatal circuits increases phasic dopamine release and alters dorsal striatal connectivity: implications for schizophrenia
One of the most robust neurochemical abnormalities reported in patients with schizophrenia is an increase in dopamine (DA) synthesis and release,...
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Interactions of calmodulin kinase II with the dopamine transporter facilitate cocaine-induced enhancement of evoked dopamine release
Typical and atypical dopamine uptake inhibitors (DUIs) prefer distinct conformations of the dopamine transporter (DAT) to form ligand-transporter...
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Seasonal variation in D2/3 dopamine receptor availability in the human brain
PurposeBrain functional and physiological plasticity is essential to combat dynamic environmental challenges. The rhythmic dopamine signaling...
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Prefrontal cortical dopamine deficit may cause impaired glucose metabolism in schizophrenia
The brain neurotramsmitter dopamine may play an important role in modulating systemic glucose homeostasis. In seven hundred and four drug- naïve...
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Role of dopamine agonists in Parkinson's disease therapy
Dopamine agonists are an important component of Parkinson's therapy. When weighing up the various therapy options, therapy with levodopa has recently...
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Chronic social stressors and striatal dopamine functioning in humans: A systematic review of SPECT and PET studies
The dopamine hypothesis of schizophrenia posits that elevated striatal dopamine functioning underlies the development of psychotic symptoms. Chronic...
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cAMP-mediated upregulation of HCN channels in VTA dopamine neurons promotes cocaine reinforcement
Chronic cocaine exposure induces enduring neuroadaptations that facilitate motivated drug taking. Hyperpolarization-activated cyclic nucleotide-gated...
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Methylphenidate undermines or enhances divergent creativity depending on baseline dopamine synthesis capacity
Catecholamine-enhancing psychostimulants, such as methylphenidate have long been argued to undermine creative thinking. However, prior evidence for...
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Effects of psychedelic, DOI, on nucleus accumbens dopamine signaling to predictable rewards and cues in rats
Psychedelics produce lasting therapeutic responses in neuropsychiatric diseases suggesting they may disrupt entrenched associations and catalyze...
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Subcutaneous adipose tissue dopamine D2 receptor is increased in prediabetes and T2D
PurposeTo evaluate the dopaminergic signaling in human adipose tissue in the context of obesity and type 2 diabetes (T2D) and potential direct...
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Dopamine D2 receptors in nucleus accumbens cholinergic interneurons increase impulsive choice
Impulsive choice, often characterized by excessive preference for small, short-term rewards over larger, long-term rewards, is a prominent feature of...
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The development of compulsive coping behavior depends on dorsolateral striatum dopamine-dependent mechanisms
Humans greatly differ in how they cope with stress, a natural behavior learnt through negative reinforcement. Some individuals engage in displacement...
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Dopamine dysfunction in depression: application of texture analysis to dopamine transporter single-photon emission computed tomography imaging
Dopamine dysfunction has been associated with depression. However, results of recent neuroimaging studies on dopamine transporter (DAT), which...
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Cardiac 18F-dopamine positron emission tomography predicts the type of phenoconversion of pure autonomic failure
PurposePure autonomic failure (PAF) is a rare disease characterized by neurogenic orthostatic hypotension (nOH), no known secondary cause, and lack...
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Toxic interactions between dopamine, α-synuclein, monoamine oxidase, and genes in mitochondria of Parkinson’s disease
Parkinson’s disease is characterized by its distinct pathological features; loss of dopamine neurons in the substantia nigra pars compacta and...
