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Cushing’s disease and bone
Bone impairment associated with Cushing’s disease (CD) is a complex disorder, mainly involving deterioration of bone quality and resulting in an...
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Dynamic functional connectivity changes associated with psychiatric traits and cognitive deficits in Cushing’s disease
Cushing’s disease is a rare neuroendocrine disorder with excessive endogenous cortisol, impaired cognition, and psychiatric symptoms. Evidence from...
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Different patient versus provider perspectives on living with Cushing’s disease
ContextPatients with Cushing’s disease (CD) face challenges living with and receiving appropriate care for this rare, chronic condition. Even with...
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Cardiac disease in Cushing’s syndrome. Emphasis on the role of cardiovascular magnetic resonance imaging
BackgroundCushing’s Syndrome (CS) is associated with increased cardiovascular morbidity and mortality. In endogenous CS, cardiovascular mortality...
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Cushing’s disease: role of bilateral adrenalectomy
IntroductionLaparoscopic bilateral adrenalectomy (BAD) is one of the treatments of Cushing’s Disease (CD), but its indications and outcome is debated.
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Pituitary apoplexy in cushing’s disease: a single center study and systematic literature review
IntroductionPituitary apoplexy (PA) in Cushing’s disease (CD) is rare with data limited to case reports/series.
MethodsWe retrospectively reviewed...
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HOW I DO IT: Cushing’s disease—selective adenomectomy via an endoscopic transsphenoidal approach
BackgroundAn ACTH-secreting pituitary adenoma is the most common cause of excessive endogenous glucocorticoid production resulting in Cushing’s...
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Repeat endoscopic endonasal transsphenoidal surgery for residual or recurrent Cushing’s disease: safety, feasibility, and success
PurposeThe success and outcomes of repeat endoscopic transsphenoidal surgery (ETS) for residual or recurrent Cushing’s disease (CD) are underreported...
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Modern imaging in Cushing’s disease
Management of Cushing’s disease is informed by dedicated imaging of the sella and parasellar regions. Although magnetic resonance imaging (MRI)...
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Proximal muscle weakness as the sole manifestation of Cushing’s disease, misdiagnosed as dermatomyositis: a case report
BackgroundCushing’s syndrome consists of signs and symptoms related to prolonged exposure to high levels of glucocorticoid, and should be considered...
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Cushing’s disease: adrenal steroidogenesis inhibitors
Cushing’s disease (CD), caused by an adrenocorticotropic hormone (ACTH)-secreting pituitary tumor, is the most common form of Cushing’s syndrome...
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The hypothalamic-pituitary-gonad axis in male Cushing’s disease before and after curative surgery
ObjectiveGonadal and sexual disturbances are commonly encountered in patients with Cushing’s disease. Nevertheless, the prevalence of hypogonadism in...
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The relationship between temporal muscle thickness and disease activity in Cushing’s disease
ObjectiveThis study aimed to investigate the relationship between hypercortisolism and temporal muscle thickness (TMT) in Cushing's disease (CD).
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Cardiovascular health and mortality in Cushing’s disease
Exposure to cortisol excess in Cushing’s disease (CD) results in increased cardiovascular morbidity and reduces survival, with cardiovascular disease...
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Pregnancy after pituitary surgery does not influence the recurrence of Cushing’s disease
PurposePregnancy is associated with the activation of the hypothalamus–pituitary–adrenal axis, which can cause a misdiagnosis of Cushing’s syndrome....
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Cushing’s disease: role of preoperative and primary medical therapy
Transsphenoidal surgery is the first-line treatment for Cushing’s disease. However, some situations may require the use of a primary medical...
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Machine learning models for differential diagnosis of Cushing’s disease and ectopic ACTH secretion syndrome
BackgroundUsing machine learning (ML) to explore the noninvasive differential diagnosis of Cushing’s disease (CD) and ectopic corticotropin (ACTH)...
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Genetics of Cushing’s disease: from the lab to clinical practice
Cushing’s disease is a rare, but devastating condition, caused by corticotroph tumors. It rarely manifests as syndrome and very few isolated cases...
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Pituitary surgery for Cushing’s disease
BackgroundSurgery is currently the first-line treatment of Cushing’s disease. Surgery for Cushing’s patients requires technical specificity,...
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Pituitary surgery in Cushing’s disease: first line treatment and role of reoperation
Cushing’s disease is the most common cause of endogenous hypercortisolemia, and transsphenoidal surgery remains the first line therapy for removal of...
