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CAR virus receptor mediates erythroid differentiation and migration and is downregulated in MDS
Myelodysplastic syndromes (MDS) are myeloid neoplasms presenting with dysplasia in the bone marrow (BM) and peripheral cytopenia. In most patients...
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Oncolytic adenovirus coding for shedding-resistant MICA enhances immune responses against tumors
Cancer immunotherapies strive to overcome tumor-induced immune suppression and activate antitumor immune responses. Although cytotoxic T lymphocytes...
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Safety, tolerability and immunogenicity of PRV-101, a multivalent vaccine targeting coxsackie B viruses (CVBs) associated with type 1 diabetes: a double-blind randomised placebo-controlled Phase I trial
Aims/hypothesisInfection with coxsackie B viruses (CVBs) can cause diseases ranging from mild common cold-type symptoms to severe life-threatening...
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Interferon Alpha-Expressing Oncolytic Adenovirus for Treatment of Esophageal Adenocarcinoma
IntroductionEsophageal adenocarcinoma (EAC) has increased in incidence in Western countries, and its poor prognosis necessitates the development of...
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Interleukin-7-loaded oncolytic adenovirus improves CAR-T cell therapy for glioblastoma
BackgroundT cell with chimeric antigen receptors (CAR-T) has presented remarkable efficacy for blood cancer as an emerging immunotherapy. However,...
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Acute myocarditis during adjuvant therapies for breast cancer: a case report
BackgroundWith the improvement of optimal perioperative drug therapy for breast cancer patients, physicians now have to treat the adverse effects and...
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Pericardial effusion caused by viral pericarditis in a patient receiving peritoneal dialysis
BackgroundAcute pericarditis causes acute inflammation of the pericardium. Although most cases of pericarditis are idiopathic with no identifiable...
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An inactivated novel chimeric FAdV-4 containing fiber of FAdV-8b provides full protection against hepatitis-hydropericardium syndrome and inclusion body hepatitis
Fowl adenovirus serotype 4 (FAdV-4) and FAdV-8b are causative agents of hepatitis-hydropericardium syndrome (HHS) and inclusion body hepatitis (IBH),...
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Cardiac arrhythmias in viral infections
BackgroundThe current COVID-19 pandemic has led to many studies examining its arrhythmogenic effects. However, there are many other viruses that are...
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The countdown to type 1 diabetes: when, how and why does the clock start?
‘The clock to type 1 diabetes has started when islet antibodies are first detected’, commented George Eisenbarth with regard to the pathogenesis of...
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Oncolytic virotherapy: basic principles, recent advances and future directions
Oncolytic viruses (OVs) have attracted growing awareness in the twenty-first century, as they are generally considered to have direct oncolysis and...
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Enhancing the antitumor activity of an engineered TRAIL-coated oncolytic adenovirus for treating acute myeloid leukemia
The use of oncolytic viruses has emerged as a promising therapeutic approach due to the features of these viruses, which selectively replicate and...
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Changing clinical characteristics of pediatric inpatients with pneumonia during COVID-19 pandamic: a retrospective study
BackgroundThe COVID-19 pandemic have impacts on the prevalence of other pathogens and people’s social lifestyle. This study aimed to compare the...
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Telomerase-specific oncolytic immunotherapy for promoting efficacy of PD-1 blockade in osteosarcoma
Immune checkpoint inhibitors including anti-programmed cell death 1 (PD-1) antibody have recently improved clinical outcome in certain cancer...
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Wuhan 3 years after the outbreak of the pandemic—cardiological insights and perspectives
In November 2019, Wuhan, a city in Central China, became the center of an outbreak of pneumonia of unknown cause, which was later named “coronavirus...
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Oncolytic viral vectors in the era of diversified cancer therapy: from preclinical to clinical
With the in-depth research and wide application of immunotherapy recently, new therapies based on oncolytic viruses are expected to create new...
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Oncolytic adenoviruses and the treatment of pancreatic cancer: a review of clinical trials
PurposePancreatic ductal adenocarcinoma (PDAC) remains a common and difficult cancer to treat. Surgical resection and chemotherapy are standard of...
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Unexpected subcellular distribution of a specific isoform of the Coxsackie and adenovirus receptor, CAR-SIV, in human pancreatic beta cells
Aims/hypothesisThe Coxsackie and adenovirus receptor (CAR) is a transmembrane cell-adhesion protein that serves as an entry receptor for...
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Oncolytic viruses against cancer, promising or delusion?
Cancer treatment is one of the most challenging topics in medical sciences. Different methods such as chemotherapy, tumor surgery, and immune...
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Subacute thyroiditis presenting as simple acute headache was misdiagnosed as meningitis: case report and literature review
BackgroundThe relationship between headache and thyrotoxicosis has been occasionally mentioned in case reports, but there are few related reports....
