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Molecular mechanisms of tumour development in glioblastoma: an emerging role for the circadian clock
Glioblastoma is one of the most lethal cancers with current therapeutic options lacking major successes. This underlines the necessity to understand...
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Circadian clock gene Clock-Bmal1 regulates cellular senescence in Chronic obstructive pulmonary disease
Chronic obstructive pulmonary disease (COPD) is a progressive respiratory disease. COPD is associated with accelerated lung aging. Circadian clock is...
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Molecular characterization of the circadian clock in paediatric leukaemia patients: a prospective study protocol
BackgroundIn many organisms, including humans, the timing of cellular processes is regulated by the circadian clock. At the molecular level the...
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Molecular circadian clock disruption in the leukocytes of individuals with type 2 diabetes and overweight, and its relationship with leukocyte–endothelial interactions
Aims/hypothesisAlterations in circadian rhythms increase the likelihood of developing type 2 diabetes and CVD. Circadian rhythms are controlled by...
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Influence of AMPK on the Functioning of the Circadian Clock and Its Possible Role in the Development of Age-Related Metabolic Disorders
AbstractCircadian rhythms ensure the synchronization of the physiology of cells and tissues in accordance with daily changes in the environment....
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Pressure Building Against the Clock: The Impact of Circadian Misalignment on Blood Pressure
Purpose of ReviewMisalignment between the endogenous biological timing system and behavioral activities (i.e., sleep/wake, eating, activity)...
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SIRT1 activation and its circadian clock control: a promising approach against (frailty in) neurodegenerative disorders
With the increase in life expectancy, the incidence of neurodegenerative disorders and their impact worldwide has been increasing in recent years....
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The trilateral interactions between mammalian target of rapamycin (mTOR) signaling, the circadian clock, and psychiatric disorders: an emerging model
Circadian (~24 h) rhythms in physiology and behavior are evolutionarily conserved and found in almost all living organisms. The rhythms are...
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Rapid-acting antidepressants and the circadian clock
A growing number of epidemiological and experimental studies has established that circadian disruption is strongly associated with psychiatric...
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Chronodisruption and Ambulatory Circadian Monitoring in Cancer Patients: Beyond the Body Clock
Purpose of ReviewCircadian rhythms impose daily rhythms a remarkable variety of metabolic and physiological functions, such as cell proliferation,...
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Altered circadian clock gene expression in the sperm of infertile men with asthenozoospermia
PurposeMale infertility is a complex multifactorial pathological condition, and asthenozoospermia (AZS) is one of the most common causes. Current...
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Biological Clock Genes are Crucial and Promising Biomarkers for the Therapeutic Targets and Prognostic Assessment in Gastric Cancer
BackgroundGastric cancer is one of the major public health problems worldwide. Circadian rhythm disturbances driven by circadian clock genes play a...
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Metabolism and exercise: the skeletal muscle clock takes centre stage
Circadian rhythms that influence mammalian homeostasis and overall health have received increasing interest over the past two decades. The molecular...
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Circadian regulation of liver function: from molecular mechanisms to disease pathophysiology
A wide variety of liver functions are regulated daily by the liver circadian clock and via systemic circadian control by other organs and cells...
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Circadian effects of ionizing radiation on reproductive function and clock genes expression in male mouse
BackgroundExposure to the ionizing radiation (IR) encountered outside the magnetic field of the Earth poses a persistent threat to the reproductive...
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The neurophysiologic basis of the human sleep–wake cycle and the physiopathology of the circadian clock: a narrative review
The objectives of this review were to explain the neurologic processes that control the human sleep–wake cycle as well as the pathophysiology of the...
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Clocking cancer: the circadian clock as a target in cancer therapy
Disruption of the cellular pathway modulating endogenous 24-h rhythms, referred to as “the circadian clock”, has been recently proven to be...
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Age-Related Changes in Circadian Rhythm and Association with Nutrition
Purpose of ReviewConsidering the increase in life expectancy, there is a time-related decline in biological functions. Age-related changes are also...
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Effects of volatile anesthetics on circadian rhythm in mice: a comparative study of sevoflurane, desflurane, and isoflurane
PurposeVolatile anesthetics affect the circadian rhythm of mammals, although the effects of different types of anesthetics are unclear. Here, we...
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Combined genotype of HCRTR2 and CLOCK variants in a large family of cluster headache with familial periodicity phenotype
PurposeCluster headache (CH) is a debilitating condition with severe and recurrent headaches characterized by circannual and circadian rhythms. A...
