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Growth speed of large brain metastases between diagnostic and radiosurgical planning MRI and predictors of rapid tumor growth
PurposeWe aimed to assess volumetric changes of large brain metastases (≥ 2 cm) between their diagnosis and planning for treatment with fractionated...
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Fetal brain growth and infant autistic traits
BackgroundStructural differences exist in the brains of autistic individuals. To date only a few studies have explored the relationship between fetal...
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Maternal Uterine Artery Adenoviral Vascular Endothelial Growth Factor (Ad.VEGF-A165) Gene Therapy Normalises Fetal Brain Growth and Microglial Activation in Nutrient Restricted Pregnant Guinea Pigs
Fetal growth restriction (FGR) is associated with uteroplacental insufficiency, and neurodevelopmental and structural brain deficits in the infant....
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New findings on brain actions of growth hormone and potential clinical implications
Growth hormone (GH) is secreted by somatotropic cells of the anterior pituitary gland. The classical effects of GH comprise the stimulation of cell...
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Ultrasonographic evaluation of the early brain growth pattern in very low birth weight infants
BackgroundPreterm infants develop smaller brain volumes compared to term newborns. Our aim is to study early brain growth related to perinatal...
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The neurobiology of insulin-like growth factor I: From neuroprotection to modulation of brain states
After decades of research in the neurobiology of IGF-I, its role as a prototypical neurotrophic factor is undisputed. However, many of its actions in...
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Temporal Evolution of Perihematomal Blood-Brain Barrier Compromise and Edema Growth After Intracerebral Hemorrhage
PurposeThe aim of this study was to investigate the temporal evolution of perihematomal blood-brain barrier (BBB) compromise and edema growth and to...
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Relationship of early brain growth pattern measured by ultrasound with neurological outcome at two years of age in very low birth weight infants
The purpose of this study is to define the impact of early brain growth trajectory in very low birth weight infants (VLBWI) on neurological prognosis...
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Apparent diffusion coefficient value of brain metastasis from lung carcinoma as potential predictor of epidermal growth factor receptor mutation
BackgroundLung carcinoma metastases to the brain occurred in 40% of all lung carcinoma cases and it occupied the top ranking of mortality of cancers....
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Brain white matter alterations in young adult male patients with childhood-onset growth hormone deficiency: a diffusion tensor imaging study
PurposeThis study aimed to detect white matter changes and different effects of thyroid hormone on the white matter integrity in young adult male...
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Maternal PUFAs, Placental Epigenetics, and Their Relevance to Fetal Growth and Brain Development
Dietary polyunsaturated fatty acids (PUFAs), especially omega-3 (n-3) and n-6 long-chain (LC) PUFAs, are indispensable for the fetus’ brain supplied...
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Postoperative Outcomes, and Growth and Brain Injury Outcomes in Spontaneous Intestinal Perforation vs Surgical Necrotizing Enterocolitis in Preterm Infants
ObjectivesTo compare the clinical outcomes in preterm infants following surgical necrotizing enterocolitis (sNEC) and spontaneous intestinal...
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Nerve Growth Factor and Brain-Derived Neurotrophic Factor as Potential Biomarkers of Mirabegron Efficacy in Patients with Overactive Bladder Syndrome
IntroductionOveractive Bladder Syndrome (OAB) significantly impacts quality of life, necessitating improved diagnostic tools and treatment...
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Association between vascular endothelial growth factor-mediated blood–brain barrier dysfunction and stress-induced depression
Several lines of evidence suggest that stress induces the neurovascular dysfunction associated with increased blood–brain barrier (BBB) permeability,...
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Brain volumes and white matter microstructure in 8- to 10-year-old children born with fetal growth restriction
BackgroundFetal growth restriction caused by placental insufficiency is associated with increased risk of poor neurodevelopment, even in the absence...
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Immune checkpoint inhibitor treatment of brain metastasis associated with a less invasive growth pattern, higher T-cell infiltration and raised tumor ADC on diffusion weighted MRI
BackgroundBrain metastases are the most common intracranial tumors with an increasing incidence. They are an important cause of morbidity and...
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Right brain-to-right brain psychotherapy: recent scientific and clinical advances
This article overviews my recent acceptance of a Lifetime Achievement Award from Sapienza University of Rome, in which I discussed three decades of...
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Brain morphometry and estimation of aging brain in subjects with congenital untreated isolated GH deficiency
PurposeIndividuals with isolated GH deficiency (IGHD) due to a mutation in the GHRH receptor gene have a normal life expectancy and above 50 years of...
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Gastrointestinal and brain barriers: unlocking gates of communication across the microbiota–gut–brain axis
Crosstalk between gut and brain has long been appreciated in health and disease, and the gut microbiota is a key player in communication between...
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Genomic medicine advances for brain tumors
Cancer genome profiling has revealed important genetic alterations that serve as prognostic indicators and guides for treatment decisions, enabling...
