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Astrocytes in the adult dentate gyrus—balance between adult and developmental tasks
Astrocytes, a major glial cell type in the brain, are indispensable for the integration, maintenance and survival of neurons during development and...
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Astrocytes modulate cerebral blood flow and neuronal response to cocaine in prefrontal cortex
Cocaine affects both cerebral blood vessels and neuronal activity in brain. Cocaine can also disrupt astrocytes, which modulate neurovascular...
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Revisiting the critical roles of reactive astrocytes in neurodegeneration
Astrocytes, an integral component of the central nervous system (CNS), contribute to the maintenance of physiological homeostasis through their roles...
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Review on the role of hypothalamic astrocytes in the neuroendocrine control of metabolism
Astrocytes are the most numerous type of glial cells found in the nervous system. They regulate energy homeostasis in collaboration with the neuronal...
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Functional roles of reactive astrocytes in neuroinflammation and neurodegeneration
Despite advances in uncovering the mechanisms that underlie neuroinflammation and neurodegenerative disease, therapies that prevent neuronal loss...
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The Role of Astrocytes in Migraine with Cortical Spreading Depression: Protagonists or Bystanders? A Narrative Review
Cortical spreading depression (CSD) is a slow wave of cortical depolarization closely associated with migraines with an aura. Previously, it was...
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Aberrant CHCHD2-associated mitochondriopathy in Kii ALS/PDC astrocytes
Amyotrophic Lateral Sclerosis/Parkinsonism-Dementia Complex (ALS/PDC), a rare and complex neurological disorder, is predominantly observed in the...
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Does decreased autophagy and dysregulation of LC3A in astrocytes play a role in major depressive disorder?
Astrocytic dysfunction contributes to the molecular pathogenesis of major depressive disorder (MDD). However, the astrocytic subtype that mainly...
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A comprehensive exploration of astrocytes in migraine: a bibliometric and visual analysis
BackgroundMigraine, as a prevalent neurologic disorder, involves intricate and yet incompletely elucidated pathophysiological mechanisms. A plethora...
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Modulatory effect of exercise on reactive astrocytes in the somatosensory cortex of epileptic rats
BackgroundAstrocytes as the most abundant brain cells play a variety of critical roles in neuroplasticity and normal brain function. Many epileptic...
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Voltage-gated potassium channels control extended access cocaine seeking: a role for nucleus accumbens astrocytes
Dopaminergic signaling in the nucleus accumbens shell (NAc) regulates neuronal activity relevant to reward-related learning, including...
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Spinal cord astrocytes regulate myocardial ischemia–reperfusion injury
Astrocytes play a key role in the response to injury and noxious stimuli, but its role in myocardial ischemia–reperfusion (I/R) injury remains...
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Protein profiling of extracellular vesicles from iPSC-derived astrocytes of patients with ALS/PDC in Kii peninsula
BackgroundAmyotrophic lateral sclerosis/Parkinsonism-dementia complex in Kii peninsula, Japan (Kii ALS/PDC), is an endemic neurodegenerative disease...
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Astrocytes in the initiation and progression of epilepsy
Epilepsy affects ~65 million people worldwide. First-line treatment options include >20 antiseizure medications, but seizure control is not achieved...
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Activation of astrocytes in the basal forebrain in mice facilitates isoflurane-induced loss of consciousness and prolongs recovery
ObjectivesGeneral anesthesia results in a state of unconsciousness that is similar to sleep. In recent years, increasing evidence has reported that...
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Brain stars take the lead during critical periods of early postnatal brain development: relevance of astrocytes in health and mental disorders
In the brain, astrocytes regulate shape and functions of the synaptic and vascular compartments through a variety of released factors and...
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Induced pluripotent stem cell-derived astrocytes from patients with schizophrenia exhibit an inflammatory phenotype that affects vascularization
Molecular and functional abnormalities of astrocytes have been implicated in the etiology and pathogenesis of schizophrenia (SCZ). In this study, we...
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Mechanobiological responses of astrocytes in optic nerve head due to biaxial stretch
BackgroundElevated intraocular pressure (IOP) is the main risk factor for glaucoma, which might cause the activation of astrocytes in optic nerve...
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Development of opioid-induced hyperalgesia depends on reactive astrocytes controlled by Wnt5a signaling
Opioids are the frontline analgesics for managing various types of pain. Paradoxically, repeated use of opioid analgesics may cause an exacerbated...
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EZH2-Myc driven glioblastoma elicited by cytomegalovirus infection of human astrocytes
Mounting evidence is identifying human cytomegalovirus (HCMV) as a potential oncogenic virus. HCMV has been detected in malignant gliomas. EZH2 and...
