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Psychogenic Aging: A Novel Prospect to Integrate Psychobiological Hallmarks of Aging
Psychological factors are amongst the most robust predictors of healthspan and longevity, yet are rarely incorporated into scientific and medical...
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Ovarian Aging
Ovarian aging is a core factor in female aging, leading not only to reduced reproductive function such as infertility, recurrent pregnancy loss and...
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Brain Aging
AbstractBrain aging is part of the aging of the whole body, largely determining the success of general aging and the quality of life of an older...
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Epigenetic regulation of aging: implications for interventions of aging and diseases
Aging is accompanied by the decline of organismal functions and a series of prominent hallmarks, including genetic and epigenetic alterations. These...
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Aging and aging-related diseases: from molecular mechanisms to interventions and treatments
Aging is a gradual and irreversible pathophysiological process. It presents with declines in tissue and cell functions and significant increases in...
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Psychosocial and biological pathways to aging
While the biological hallmarks of aging are widely recognized as fundamental mechanisms of biological aging, more recently, there have been calls...
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Obesity and Accelerated Aging
The population of older adults with obesity is rapidly increasing. Through shared pathophysiologic mechanisms, obesity exacerbates the age-related...
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Basic Epigenetic Mechanisms of Aging
AbstractThe process of aging is a complex biological phenomenon that is influenced by multiple factors, including genetics, environment, and...
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Female germline stem cells: aging and anti-aging
The delay of ovarian aging and the fertility preservation of cancer patients are the eternal themes in the field of reproductive medicine. Acting as...
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Inflammation and aging: signaling pathways and intervention therapies
Aging is characterized by systemic chronic inflammation, which is accompanied by cellular senescence, immunosenescence, organ dysfunction, and...
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Metabolic syndrome and epigenetic aging: a twin study
BackgroundMetabolic syndrome (MetS) is associated with premature aging, but whether this association is driven by genetic or lifestyle factors...
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Mechanisms of Neurocognitive Adaptation during Aging Process
AbstractHuman aging is associated with an increased risk of various geriatric syndromes, cognitive impairment being among the most frequent. The most...
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Trauma, adversity, and biological aging: behavioral mechanisms relevant to treatment and theory
Although stress and adversity are largely universal experiences, people exposed to greater hardship are at increased risk for negative health...
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Targeting the “hallmarks of aging” to slow aging and treat age-related disease: fact or fiction?
Aging is a major risk factor for a number of chronic diseases, including neurodegenerative and cerebrovascular disorders. Aging processes have...
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Ovarian aging: energy metabolism of oocytes
In women who are getting older, the quantity and quality of their follicles or oocytes and decline. This is characterized by decreased ovarian...
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Key Age-Friendly Components of Municipalities that Foster Social Participation of Aging Canadians: Results from the Canadian Longitudinal Study on Aging
Municipalities can foster the social participation of aging adults. Although making municipalities age-friendly is recognized as a promising way to...
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Transcriptional Regulation in the Control of Aging and Longevity
AbstractTranscription regulation is required for correct differential gene expression, which determines the development and function of all cells in...
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The Impact of Aging on Multiple Sclerosis
Purpose of ReviewMultiple sclerosis (MS) is a chronic, immune-mediated demyelinating disorder of the central nervous system. Age is one of the most...
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Posttraumatic stress disorder, trauma, and accelerated biological aging among post-9/11 veterans
People who experience trauma and develop posttraumatic stress disorder (PTSD) are at increased risk for poor health. One mechanism that could explain...
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Validation of the Health Assessment Tool (HAT) based on four aging cohorts from the Swedish National study on Aging and Care
BackgroundAs global aging accelerates, routinely assessing the functional status and morbidity burden of older patients becomes paramount. The aim of...
