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The effects of AdipoRon on cytochrome P450-related gene expression, acute steroidogenic regulatory protein, and structure of ovary in polycystic ovary syndrome model
PurposeOne of the most common causes of infertility in adult women is polycystic ovary syndrome (PCOS) which has been identified with symptoms such...
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Adiponectin receptor agonist AdipoRon ameliorates renal inflammation in diet-induced obese mice and endotoxin-treated human glomeruli ex vivo
Aims/hypothesisChronic low-grade inflammation with local upregulation of proinflammatory molecules plays a role in the progression of obesity-related...
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AdipoRon Attenuates Hypertension-Induced Epithelial-Mesenchymal Transition and Renal Fibrosis via Promoting Epithelial Autophagy
Hypertension-induced epithelial-mesenchymal transition (EMT) is a major mechanism of renal fibrosis. Adiponectin protects against...
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AdipoRon, an adiponectin receptor agonist, protects contrast-induced nephropathy by suppressing oxidative stress and inflammation via activation of the AMPK pathway
BackgroundContrast-induced nephropathy (CIN), a complication caused by using contrast medium during diagnostic and interventional procedures, occurs...
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Chronic oral administration of adipoRon reverses cognitive impairments and ameliorates neuropathology in an Alzheimer’s disease mouse model
Circulating adiponectin (APN) levels decrease with age and obesity. On the other hand, a reduction in APN levels is associated with neurodegeneration...
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Anti-depressive-like behaviors of APN KO mice involve Trkb/BDNF signaling related neuroinflammatory changes
Major depression disorder is a severe mental illness often linked with metabolic disorders. Adiponectin is an adipocyte-secreted circulatory hormone...
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Adiporon, an adiponectin receptor agonist acts as an antidepressant and metabolic regulator in a mouse model of depression
Major depression is a psychiatric disorder with complex etiology. About 30% of depressive patients are resistant to antidepressants that are...
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Potential Protective Function of Adiponectin in Diabetic Retinopathy
Adiponectin, one of the most ubiquitous adipokines found in the blood, plays a major role in glucolipid metabolism and energy metabolism and...
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Drug development research for novel adiponectin receptor-targeted antidiabetic drugs contributing to healthy longevity
It is well recognized that the decrease of adiponectin associated with high-fat diet and lack of exercise accounts for the onset of insulin...
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Duchenne muscular dystrophy: pathogenesis and promising therapies
Duchenne muscular dystrophy (DMD) is a severe, progressive, muscle-wasting disease, characterized by progressive deterioration of skeletal muscle...
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An adiponectin-S1P axis protects against lipid induced insulin resistance and cardiomyocyte cell death via reduction of oxidative stress
BackgroundAdiponectin exerts several beneficial cardiovascular effects, however their specific molecular mechanisms require additional understanding....
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Ceramides and other sphingolipids as drivers of cardiovascular disease
Increases in calorie consumption and sedentary lifestyles are fuelling a global pandemic of cardiometabolic diseases, including coronary artery...
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Potential factors result in diminished ovarian reserve: a comprehensive review
The ovarian reserve is defined as the quantity of oocytes stored in the ovary or the number of oocytes that can be recruited. Ovarian reserve can be...
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Molecular mechanisms of exercise contributing to tissue regeneration
Physical activity has been known as an essential element to promote human health for centuries. Thus, exercise intervention is encouraged to battle...
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AMPK as a mediator of tissue preservation: time for a shift in dogma?
Ground-breaking discoveries have established 5′-AMP-activated protein kinase (AMPK) as a central sensor of metabolic stress in cells and tissues....
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Mitochondrial dynamics in health and disease: mechanisms and potential targets
Mitochondria are organelles that are able to adjust and respond to different stressors and metabolic needs within a cell, showcasing their plasticity...
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Adiponectin modulates ventral tegmental area dopamine neuron activity and anxiety-related behavior through AdipoR1
Adiponectin, a metabolic hormone secreted by adipocytes, can cross the blood–brain barrier to act on neurons in different brain regions, including...
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Metabolism regulator adiponectin prevents cardiac remodeling and ventricular arrhythmias via sympathetic modulation in a myocardial infarction model
The stellate ganglia play an important role in cardiac remodeling after myocardial infarction (MI). This study aimed to investigate whether...
