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Clinical immunotherapy in pancreatic cancer
Pancreatic cancer remains a challenging disease with limited treatment options, resulting in high mortality rates. The predominant approach to...
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Research trends in alopecia areata: a cross-sectional bibliometric analysis of the top cited studies
In the field of alopecia areata research, various focuses including risk factors, epidemiology, molecular pathways, and treatment were constantly...
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A brief report on incidence, radiographic feature and prognostic significance of brain MRI changes after anti-PD-1/PD-L1 therapy in advanced non-small cell lung cancer
IntroductionNeurologic immune-related adverse events (nirAEs) are uncommon but potentially lethal complications of immune checkpoint inhibitor (ICI)...
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Role of gut microbiome in cancer immunotherapy: from predictive biomarker to therapeutic target
Immunotherapy has emerged as an effective treatment for various types of cancers. Recent studies have highlighted a significant correlation between...
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The secretion profile of mesenchymal stem cells and potential applications in treating human diseases
Mesenchymal stromal/stem cells (MSCs) possess multi-lineage differentiation and self-renewal potentials. MSCs-based therapies have been widely...
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Clinical Considerations for RPE Cell Transplantation
Purpose of ReviewTransplantation of retinal pigment epithelium (RPE) derived from either induced pluripotent stem cells (iPSCs) or embryonic stem...
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The application and progression of CRISPR/Cas9 technology in ophthalmological diseases
The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated nuclease (Cas) system is an adaptive immune defence system...
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Immunometabolism: a new dimension in immunotherapy resistance
Immune checkpoint inhibitors (ICIs) have demonstrated unparalleled clinical responses and revolutionized the paradigm of tumor treatment, while...
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Smokers or non-smokers: who benefits more from immune checkpoint inhibitors in treatment of malignancies? An up-to-date meta-analysis
BackgroundImmune checkpoint inhibitors, which are a milestone in anti-cancer therapy, have been applied in the treatment of multiple malignancies....
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The Eye of the Storm: COVID-19 Vaccination and the Eye
The COVID-19 pandemic has galvanized the global response towards the development of new vaccines based on novel technologies at an unprecedented...
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Targeting macrophage migration inhibitory factor (MIF): a promising therapy for inflammatory ocular diseases
Inflammatory ocular diseases are characterized by the presence of a persistent inflammatory response which cause tissue injury, decrease visual...
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Macrophage migration inhibitory factor polymorphism (rs755622) in alopecia areata: a possible role in disease prevention
Alopecia areata (AA) is an organ-specific autoimmune disease that targets the bulb of the hair follicles and results in non-scarring hair loss that...
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Identification of anti-microbial peptides and traces of microbial DNA in infrainfundibular compartments of human scalp terminal hair follicles
BackgroundThe upper follicular compartment, a well-known reservoir of cutaneous microbiota, constitutes a space for intensive cross-barrier dialogue....
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Lens-induced uveitis: an update
Ocular inflammation resulting from a lens pathology is rare in the absence of a cataract or lens trauma because of the lens’ immune privilege. The...
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Toxoplasma gondii-derived antigen modifies tumor microenvironment of Ehrlich solid carcinoma murine model and enhances immunotherapeutic activity of cyclophosphamide
Pathogen-based cancer vaccine is a promising immunotherapeutic weapon to stimulate cancer immunosuppressive state. Toxoplasma gondii is a potent...
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Investigating the effects of PTEN mutations on cGAS-STING pathway in glioblastoma tumours
BackgroundPTEN is a tumour suppressor gene and well-known for being frequently mutated in several cancer types. Loss of immunogenicity can also be...
