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HHLA2 in intrahepatic cholangiocarcinoma: an immune checkpoint with prognostic significance and wider expression compared with PD-L1
BackgroundIntrahepatic cholangiocarcinoma (ICC) is a highly mortal malignancy with limited therapeutic options. Immunotherapies targeting PD-1/PD-L1...
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Global long terminal repeat activation participates in establishing the unique gene expression programme of classical Hodgkin lymphoma
Long terminal repeat (LTR) elements are wide-spread in the human genome and have the potential to act as promoters and enhancers. Their expression is...
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Prospects in the Search for Peptides for Specific Regulation of Aging
AbstractThe interspecies differences in the mean lifespan and the composition of transposon sequences, the tissue- and stage-specific activation of...
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5-hydroxymethylcytosine but not MTAP methylation status can stratify malignant pleural mesothelioma based on the lineage of origin
BackgroundMalignant pleural mesothelioma (MPM) is an aggressive tumor with poor prognosis, mainly associated with work or environmental exposure to...
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The complement system: a gateway to gene–environment interactions in schizophrenia pathogenesis
The pathogenesis of schizophrenia is considered to be multi-factorial, with likely gene–environment interactions (GEI). Genetic and environmental...
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Molecular Subtypes of Prostate Cancer
Purpose of ReviewThis review will examine the taxonomy of PCa subclasses across disease states, explore the relationship among specific alterations,...
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Competitive glucose metabolism as a target to boost bladder cancer immunotherapy
Bladder cancer — the tenth most frequent cancer worldwide — has a heterogeneous natural history and clinical behaviour. The predominant histological...
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Neuropil contraction in relation to Complement C4 gene copy numbers in independent cohorts of adolescent-onset and young adult-onset schizophrenia patients–a pilot study
A recent report suggested Complement 4 (C4A) gene copy numbers (GCN) as risk factors for schizophrenia. Rodent model showed association of C4 with...
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Expression and Regulation of Retinoic Acid Receptor Responders in the Human Placenta
IntroductionRetinoic acid (RA) signaling through its receptors (RARA, RARB, RARG, and the retinoic X receptor RXRA) is essential for healthy...
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Impact of HLA-G polymorphism on the outcome of allogeneic hematopoietic stem cell transplantation for metastatic renal cell carcinoma
Renal cell carcinoma (RCC) is particularly sensitive to immune intervention. HLA-G, a non-classical HLA class I molecule with immunomodulatory...
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Immuno-psychiatry: an agenda for clinical practice and innovative research
BackgroundThe diagnostic scheme for psychiatric disorders is currently based purely on descriptive nomenclature given that biomarkers subtypes and...
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Generating testable hypotheses for schizophrenia and rheumatoid arthritis pathogenesis by integrating epidemiological, genomic, and protein interaction data
Patients with schizophrenia and their relatives have reduced prevalence of rheumatoid arthritis. Schizophrenia and rheumatoid arthritis genome-wide...
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Two endogenous retroviral loci appear to contribute to Multiple Sclerosis
BackgroundTwo endogenous retroviral loci seem to be involved in the human disease Multiple sclerosis (MS).
ResultsThe two retroviral loci synergize...
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Epigenetics in SLE
Purpose of ReviewSystemic lupus erythematosus is a severe autoimmune/inflammatory condition of unknown pathophysiology. Though genetic predisposition...
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Integrin α8 Is Abundant in Human, Rat, and Mouse Trophoblasts
ObjectiveIntegrins exert regulatory functions in placentogenesis. Null mutation of certain integrin α subunits leads to placental defects with...
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A family study of complex chromosome rearrangement involving chromosomes 1, 8, and 11 and its reproductive consequences
Complex chromosome translocations are structural chromosomal rearrangements involving three or more chromosomes and more than two breakpoints. A...
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Pathophysiological and diagnostic implications of cortical dysfunction in ALS
Cortical dysfunction — specifically, the development of hyperexcitability — seems to be an early and intrinsic feature of sporadic and familial...
