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Drug repurposing for opioid use disorders: integration of computational prediction, clinical corroboration, and mechanism of action analyses
Morbidity and mortality from opioid use disorders (OUD) and other substance use disorders (SUD) is a major public health crisis, yet there are few...
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Psychostimulant Augmentation of Antidepressant Therapy in Depression: a Systematic Review and Meta-Analysis
Purpose of ReviewTo evaluate the effectiveness of psychostimulant augmentation of antidepressants in the treatment of depression in adults.
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Efficacy of atypical antipsychotics in the treatment of fecal incontinence in children and adolescents: a randomized clinical trial
ObjectivesFunctional retentive overflow incontinence (retentive FI) is the most common cause of fecal soiling in children. Based on the clinical...
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Distinct roles for dopamine clearance mechanisms in regulating behavioral flexibility
Dopamine plays a crucial role in adaptive behavior, and dysfunctional dopamine is implicated in multiple psychiatric conditions characterized by...
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A Scoping Review on Strategies that Enhance Medication Adherence in Children and Adolescents with Attention Deficit Hyperactivity Disorder and Associated Outcomes
Purpose of ReviewThe goal of this review was to summarize interventions aimed at improving medication adherence in pediatric ADHD. Specifically, we...
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Long-term medication for ADHD (LMA) trial: 2-year prospective observational study in children and adolescents. Core symptoms, daily functioning, and comorbidity outcomes
More knowledge is needed about long-term ADHD medication and symptom, daily functioning, comorbidity, and tolerability outcomes. This “Long-term...
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The Paradoxical Clinical Course of Persons with Gambling Disorder and Comorbid Attention-Deficit/Hyperactivity Disorder (ADHD)
The co-occurrence of gambling disorder (GD) and attention-deficit/hyperactivity disorder (ADHD) has been widely reported. In this study, we aimed to...
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Effects of repetitive transcranial magnetic stimulation in children and young people with psychiatric disorders: a systematic review
Repetitive transcranial magnetic stimulation (rTMS) has demonstrated benefits in adults with psychiatric disorders, but its clinical utility in...
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An overview on neurobiology and therapeutics of attention-deficit/hyperactivity disorder
Attention-Deficit/Hyperactivity Disorder (ADHD) is a prevalent psychiatric condition characterized by developmentally inappropriate symptoms of...