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Apolipoprotein D concentration in Parkinson’s disease patients
BackgroundParkinson’s disease (PD) is distinguished recently by an increase in inflammation and oxidative stress. Apolipoprotein D (Apo D) is a...
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Clinical characteristics of patients with suspected Alzheimer’s disease within a CSF Aß-ratio grey zone
BackgroundThe AT(N) research framework for Alzheimer's disease (AD) remains unclear on how to best deal with borderline cases. Our aim was to...
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Exploring the impact of 40 Hz multi-luminaire light exposure in Alzheimer's dementia: insights from a convenient sampling, non-randomized case–control study
BackgroundRecent studies propose 40 Hz neural activity induction as a promising approach for managing Alzheimer's dementia (AD). However, traditional...
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Memantine administration prevented chorea movement in Huntington’s disease: a case report
BackgroundHuntington’s disease is an autosomal dominant inherited disorder characterized by personality changes (such as irritability and...
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Molecular Hydrogen in Health and Disease
Molecular hydrogen (H2) has emerged as a promising therapeutic and preventive medical gas. Hydrogen gas has garnered significant attention in recent...
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Associations of screen-based sedentary activities with all cause dementia, Alzheimer’s disease, vascular dementia: a longitudinal study based on 462,524 participants from the UK Biobank
BackgroundCurrent drug treatments for dementia aren't effective. Studying gene-environment interactions can help develop personalized early...
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Cerebrospinal fluid biomarkers and genetic factors associated with normal pressure hydrocephalus and Alzheimer’s disease: a narrative review
BackgroundNormal pressure hydrocephalus is a neurologic disease leading to enlargement of ventricles which is presented with gait and balance...
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Plasma neurofilament light as a promising biomarker in neuronal intranuclear inclusion disease
Neuronal intranuclear inclusion disease (NIID) is a rare neurodegenerative disorder lacking reliable biomarkers. This study investigates plasma...
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FUS-mediated blood–brain barrier disruption for delivering anti-Aβ antibodies in 5XFAD Alzheimer’s disease mice
PurposeAmyloid-β (Aβ) peptides, the main component of amyloid plaques found in the Alzheimer's disease (AD) brain, are implicated in its...
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The role of immune and inflammatory-related indicators in cognitive dysfunction and disease severity in patients with parkinson’s disease
We aimed to explore the role of immune and inflammatory indicators in cognitive dysfunction and disease severity in patients with Parkinson's...
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Identifying the mediating role of inflammation on the relationship between socioeconomic status and Alzheimer’s disease: a Mendelian randomization analysis and mediation analysis
Background and objectivesObservational studies have demonstrated a significant association between socio-economic status (SES) and Alzheimer's...
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NFL and GFAP in (pre)symptomatic RVCL-S carriers: a monogenic cerebral small vessel disease
BackgroundNeurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) have emerged as biomarkers for cerebral small vessel disease...
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Plasma neurofilament light levels correlate with white matter damage prior to Alzheimer’s disease: results from ADNI
BackgroundThe blood biomarker neurofilament light (NFL) is one of the most widely used for monitoring Alzheimer's disease (AD). According to recent...
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Therapeutic Mechanism of Kai Xin San on Alzheimer’s Disease Based on Network Pharmacology and Experimental Validation
ObjectiveTo explore the specific pharmacological molecular mechanisms of Kai Xin San (KXS) on treating Alzheimer’s disease (AD) based on network...
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Huntington’s Disease: Latest Frontiers in Therapeutics
Purpose of ReviewHuntington’s disease (HD) is an autosomal-dominant disorder caused by a pathological expansion of a trinucleotide repeat (CAG) on...
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Association between Mediterranean diet and dementia and Alzheimer disease: a systematic review with meta-analysis
BackgroundDementia affects 5–8% of the population aged over 65 years (~50 million worldwide). Several factors are associated with increased risk,...
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The promising guide to LC–MS analysis and cholinesterase activity of Luffa cylindrica (L.) fruit using in vitro and in-silico analyses
BackgroundLuffa cylindrica (L.) is an annual climbing plant that produces fibrous fruit and can also be used as a vegetable in northern parts of...
