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Retinal functional and structural changes in patients with Parkinson’s disease
BackgroundVisual dysfunction have been well reported as one of the non-motor symptoms in Parkinson’s disease (PD). The aim of this study was to...
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LSVT® BIG versus progressive structured mobility training through synchronous telerehabilitation in Parkinson’s disease: A randomized controlled trial
BackgroundParkinson’s disease (PD) is a common neurodegenerative illness associated with motor symptoms.
AimThe aim of study was to compare the...
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Advanced therapies in Parkinson’s disease: an individualized approach to their indication
Device aided therapies (DAT) comprising the intrajejunal administration of levodopa/carbidopa intestinal gel (LCIG) and levodopa/carbidopa/entacapone...
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Development and early qualitative evidence of two novel patient-reported outcome instruments to assess daily functioning in people with early-stage Parkinson’s
BackgroundPrevious research on concepts that are important to people living with early-stage Parkinson’s indicated that ‘ functional ’ slowness, fine...
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Old problems, new solutions: harnessing technology and innovation in Parkinson’s disease—evidence and experiences from Thailand
The prevalence of Parkinson’s disease (PD) is increasing rapidly worldwide, but there are notable inequalities in its distribution and in the...
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Relationship between serum uric acid levels and the outcome of STN-DBS in Parkinson’s disease
BackgroundUric acid is a natural antioxidant and it has been shown that low levels of uric acid may be a risk factor for the development of...
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Effects of virtual reality versus motor imagery versus routine physical therapy in patients with parkinson’s disease: a randomized controlled trial
BackgroundParkinson’s Disease (PD) is the second most common progressive neurodegenerative disorder, mostly affecting balance and motor function...
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Unraveling the interplay between dyskinesia and overactive bladder symptoms in Parkinson’s disease: a comprehensive cohort study based on the long-term follow-up database of Parkinson’s disease
ObjectivesOveractive bladder (OAB) and dyskinesia are frequent complications in patients with Parkinson’s disease (PD). However, the correlation...
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Transcriptomic analysis reveals associations of blood-based A-to-I editing with Parkinson’s disease
BackgroundAdenosine-to-inosine (A-to-I) editing is the most common type of RNA editing in humans and the role of A-to-I RNA editing remains unclear...
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Validation of the Italian version of the Parkinson’s Disease- Cognitive Functional Rating Scale
A key distinguishing factor between mild cognitive impairment (MCI) and dementia in Parkinson’s disease (PD) lies in the notable decrease in...
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Mesenchymal stromal cell biotherapy for Parkinson’s disease premotor symptoms
Parkinson’s disease (PD) is a neurodegenerative disorder with motor deficits due to nigrostriatal dopamine depletion and with the non-motor/premotor...
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Parkinson’s disease therapy: what lies ahead?
The worldwide prevalence of Parkinson’s disease (PD) has been constantly increasing in the last decades. With rising life expectancy, a longer...
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Neck rigidity: a pitfall for video head-impulse tests in Parkinson’s disease
Video head impulse tests (video-HITs) are commonly used for vestibular evaluation; however, the results can be contaminated by various artifacts,...
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Effectiveness of vestibular rehabilitation on postural balance in Parkinson’s disease: a systematic review and meta-analysis of randomized controlled trials
IntroductionPostural balance impairment can affect the quality of life of patients with Parkinson’s disease. Previous studies have described...
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Neuroimaging correlates of postural instability in Parkinson’s disease
BackgroundPostural instability (PI) is a common disabling symptom in Parkinson’s disease (PD), but little is known on its pathophysiological basis.
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Assessing the validity of a Parkinson’s care evaluation: the PRIME-NL study
IntroductionThe PRIME-NL study prospectively evaluates a new integrated and personalized care model for people with parkinsonism, including...
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Impact of deep brain stimulation therapy on the vertebral sagittal balance in Parkinson’s disease patients
Parkinson’s disease (PD) is characterized by cardinal motor signs: 4–6 Hz resting tremor, rigidity, and bradykinesia. In addition, 3–18% of PD...
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Genetic testing for Parkinson’s disease in clinical practice
The identification of disease-causing mutations or strong risk factors for Parkinson’s disease in genes encoding proteins such as α-synuclein (SNCA),...
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Disease Stage and Motor Fluctuation Duration Predict Drug Tolerability: A Real-Life, Prospective Italian Multicenter Study on the Use of Opicapone in Parkinson’s Disease
BackgroundOpicapone is a third-generation catechol- O -methyl-transferase inhibitor currently used for the treatment of motor fluctuations in...
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Factors associated with a placebo effect in Parkinson’s disease in clinical trials: a meta-analysis
ObjectivesOutcomes of clinical trials of treatment in patients with Parkinson’s disease (PD) may be influenced by placebo effects. The aim of this...
