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Sex, gender, and subclinical hypertensiveorgan damage—heart
Hypertension-mediated organ damage (HMOD) at cardiac level include a variety of abnormal phenotypes of recognized adverse prognostic value. Although...
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Sex differences in metabolic regulation and diabetes susceptibility
Gender and biological sex impact the pathogenesis of numerous diseases, including metabolic disorders such as diabetes. In most parts of the world,...
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Breast-conserving surgery with whole breast radiation therapy has a subsequent lower mood disorder incidence rate than total mastectomy in early-stage breast cancer patients: a nationwide population-based longitudinal study
PurposeBreast-conserving surgery (BCS) followed by whole breast radiation therapy (BCS-WBRT) or total mastectomy without WBRT (TM-no-WBRT) is the...
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Sex-dependent intra-islet structural rearrangements affecting alpha-to-beta cell interactions lead to adaptive enhancements of Ca2+ dynamics in prediabetic beta cells
Aims/hypothesisPrediabetic pancreatic beta cells can adapt their function to maintain normoglycaemia for a limited period of time, after which...
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Gender-affirming hormone treatment: friend or foe? Long-term follow-up of 755 transgender people
PurposeGender-affirming hormone treatment (GAHT) is one of the main demands of transgender and gender diverse (TGD) people, who are usually...
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Lipidome characterisation and sex-specific differences in type 1 and type 2 diabetes mellitus
BackgroundIn this study, we evaluated the lipidome alterations caused by type 1 diabetes (T1D) and type 2 diabetes (T2D), by determining lipids...
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Polycystic ovary syndrome
Despite affecting ~11–13% of women globally, polycystic ovary syndrome (PCOS) is a substantially understudied condition. PCOS, possibly extending to...
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Improving clinical outcomes through attention to sex and hormones in research
Biological sex, fluctuations in sex steroid hormones throughout life and gender as a social construct all influence every aspect of health and...
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Central precocious puberty during COVID-19 pandemic and sleep disturbance: an exploratory study
BackgroundIncreased incidence of central precocious puberty (CPP) after coronavirus infectious disease-19 lockdown has been reported. Our study aims...
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Hormonal regulation of mammary gland development and lactation
Lactation is critical to infant short-term and long-term health and protects mothers from breast cancer, ovarian cancer and type 2 diabetes mellitus....
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Long-term and sequential treatment for osteoporosis
Osteoporosis is a skeletal disorder that causes impairment of bone structure and strength, leading to a progressively increased risk of fragility...
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Gender differences in clinical and biochemical parameters among patients hospitalized for schizophrenia: towards precision medicine
BackgroundThe scientific literature shows some gender differences in the clinical course of schizophrenia. The aim of this study is to identify...
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Recalcitrant Epistaxis: A case report of Hereditary Haemorrhagic Telangiectasia
Hereditary haemorrhagic telangiectasia, also known as Rendu–Osler–Weber disease, is an autosomal dominant disorder of the fibrovascular tissue common...
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The menstrual cycle regularity and skin: irregular menstrual cycle affects skin physiological properties and skin bacterial microbiome in urban Chinese women
BackgroundThe regularity of the menstrual cycle directly affects women’s health. Many studies have focused on menstrual health; however, menstrual...
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The role of antibody glycosylation in autoimmune and alloimmune kidney diseases
Immunoglobulin glycosylation is a pivotal mechanism that drives the diversification of antibody functions. The composition of the IgG glycome is...
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Infective endocarditis in octogenarians. A retrospective study in a single, high-volume surgical centre
BackgroundInfective endocarditis (IE) is a severe disease associated with high morbidity and mortality. Little is known about the best management of...
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Urinary Oestrogen Excretion in the Goat During the Oestrous Cycle and after Administration of Pregnant Mare Serum Gonadotrophin (PMSG)
Two goats were placed in cages constructed for urine collection. Samples were taken daily and stored in the frozen state until analysis. The urine...
