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Peripheral immunity is associated with the risk of incident dementia
Central immunity components especially microglia in dementia have been well studied and corresponding immunotherapy gradually caught the attention....
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Alopecia Areata: Current Treatments and New Directions
Alopecia areata is an autoimmune hair loss disease that is non-scarring and is characterized by chronic inflammation at the hair follicle level....
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Assessing for prenatal risk factors associated with infant neurologic morbidity using a multivariate analysis
ObjectiveTo characterize the biochemical and demographic profiles of pregnant people with maternal immune activation (MIA) and identify the prenatal...
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Risk Factors and Hazards of Recipient-Area Perifollicular Erythema After Hair Transplantation: A Multicenter Retrospective Cohort Study
BackgroundRecipient-area perifollicular erythema (RPE) may delay graft growth after hair transplantation. However, there is currently a lack of...
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Identification of a novel pyroptosis-related gene signature in human spermatogenic dysfunction
PurposeTo reveal the underlying roles that pyroptosis-related genes (PRGs) played in human spermatogenic dysfunction.
MethodsOne discovery set and...
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Vaccine Mandates and Cultural Safety
The issues and problems of mandatory vaccination policy and roll out in First Nations communities are unique and do not concern the safety and...
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Pathogenesis of Giant Cell Arteritis and Takayasu Arteritis—Similarities and Differences
Purpose of ReviewGiant cell arteritis (GCA) and Takayasu arteritis (TAK) are auto-inflammatory and autoimmune diseases with a highly selective tissue...
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The impact of patient and public involvement on COVID-19 immunology research: experiences from the UK Coronavirus Immunology Consortium
BackgroundPatient and Public Involvement (PPI) in clinical trial research is recognised as relevant but the active involvement of patients and the...
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Hyalocytes—guardians of the vitreoretinal interface
Originally discovered in the nineteenth century, hyalocytes are the resident macrophage cell population in the vitreous body. Despite this, a...
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The repertoire of tumor-infiltrating lymphocytes within the microenvironment of oral squamous cell carcinoma reveals immune dysfunction
BackgroundThe role of tumor-infiltrating lymphocytes (TILs) in the immune remodeling of tumor microenvironments (TME) in oral squamous cell carcinoma...
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The role of lipid metabolism in cancer radioresistance
Radiotherapy is one of the main therapies for cancer. The process leading to radioresistance is still not fully understood. Cancer radiosensitivity...
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Freeze-dried amniotic membrane graft with a spongy layer in bilateral peripheral ulcerative keratitis: a case report
BackgroundPeripheral ulcerative keratitis (PUK) is a group of inflammatory corneal ulcers with stromal thinning and peripheral localization. Amniotic...
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Cell-based therapies for neurological disorders — the bioreactor hypothesis
Cell-based therapies are an emerging biopharmaceutical paradigm under investigation for the treatment of a range of neurological disorders....
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[99mTc]-labelled anti-Programmed Death-Ligand 1 single-domain antibody SPECT/CT: a novel imaging biomarker for myocardial PD-L1 expression
BackgroundMyocardial programmed death-ligand 1 (PD-L1) expression is implicated in immune checkpoint inhibitor (ICI)-associated myocarditis....
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Nanomedicine‐boosting icaritin-based immunotherapy of advanced hepatocellular carcinoma
Traditional treatments for advanced hepatocellular carcinoma (HCC), such as surgical resection, transplantation, radiofrequency ablation, and...
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Classical epithelial-mesenchymal transition (EMT) and alternative cell death process-driven blebbishield metastatic-witch (BMW) pathways to cancer metastasis
Metastasis is a pivotal event that accelerates the prognosis of cancer patients towards mortality. Therapies that aim to induce cell death in...
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Targeting oncometabolism to maximize immunotherapy in malignant brain tumors
Brain tumors result in significant morbidity and mortality in both children and adults. Recent data indicate that immunotherapies may offer a...
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Clinical immunotherapy in pancreatic cancer
Pancreatic cancer remains a challenging disease with limited treatment options, resulting in high mortality rates. The predominant approach to...
