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Current State of Systemic Therapies for Advanced Renal Cell Carcinoma
Purpose of ReviewDue to the rapidly changing field of kidney cancer therapeutics, addressing the state of the art systemic therapy regimens, and...
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Postmortem evidence of brain inflammatory markers in bipolar disorder: a systematic review
Bipolar disorder (BD) is a chronic affective disorder with extreme mood swings that include mania or hypomania and depression. Though the exact...
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Intratumoural microbiota: a new frontier in cancer development and therapy
Human microorganisms, including bacteria, fungi, and viruses, play key roles in several physiological and pathological processes. Some studies...
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Up-to-date knowledge about the association between multiple sclerosis and the reactivation of human endogenous retrovirus infections
BackgroundAlthough existing studies show that reactivation of the human endogenous retrovirus (HERVs) plays a leading role in multiple sclerosis (MS)...
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Mechanism-based criteria to improve therapeutic outcomes in progressive multiple sclerosis
In contrast to the multiple disease-modifying therapies that are available for relapsing–remitting multiple sclerosis (MS), the therapeutic options...
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Current Status on Immunological Therapies for Type 1 Diabetes Mellitus
Purpose of ReviewType 1 diabetes (T1D) occurs when there is destruction of beta cells within the islets of Langerhans in the pancreas due to...
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Novel open reading frames in human accelerated regions and transposable elements reveal new leads to understand schizophrenia and bipolar disorder
Schizophrenia (SCZ) and bipolar disorder are debilitating neuropsychiatric disorders arising from a combination of environmental and genetic factors....
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The Involvement of Cell Adhesion Molecules, Tight Junctions, and Gap Junctions in Human Placentation
Placentation is a major determinant of the success of pregnancy. It is regulated by several factors such as cell adhesion molecules, tight junctions,...
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Methyltransferase-like proteins in cancer biology and potential therapeutic targeting
RNA modification has recently become a significant process of gene regulation, and the methyltransferase-like (METTL) family of proteins plays a...
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Metabolic memory: mechanisms and diseases
Metabolic diseases and their complications impose health and economic burdens worldwide. Evidence from past experimental studies and clinical trials...
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Infectious agents and amyotrophic lateral sclerosis: another piece of the puzzle of motor neuron degeneration
Amyotrophic lateral sclerosis (ALS) is the most common neurodegenerative disease affecting motor neurons (MN). This fatal disease is characterized by...
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A profile and review of findings from the Early Markers for Autism study: unique contributions from a population-based case–control study in California
BackgroundThe Early Markers for Autism (EMA) study is a population-based case–control study designed to learn more about early biologic processes...
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Novel Therapeutic Approaches and Targets Currently Under Evaluation for Renal Cell Carcinoma: Waiting for the Revolution
Management of metastatic renal cell carcinoma has drastically changed in the last few years, witnessing the advent of more and more target therapies...
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Long Noncoding RNA UCA1 Overexpression Is Associated with Poor Prognosis in Digestive System Malignancies: A Meta-analysis
Long noncoding RNA (lncRNA) urothelial carcinoma associated 1 (UCA1) has been reported to be highly expressed in many kinds of cancers. This...
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Cellular immunotherapy: a clinical state-of-the-art of a new paradigm for cancer treatment
Cancer immunotherapy has opened a new chapter in Medical Oncology. Many novel therapies are under clinical testing and some have already been...
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DNA methylation signature on phosphatidylethanol, not on self-reported alcohol consumption, predicts hazardous alcohol consumption in two distinct populations
The process of diagnosing hazardous alcohol drinking (HAD) is based on self-reported data and is thereby vulnerable to bias. There has been an...
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Investigation of candidate genes and mechanisms underlying obesity associated type 2 diabetes mellitus using bioinformatics analysis and screening of small drug molecules
BackgroundObesity associated type 2 diabetes mellitus is a metabolic disorder ; however, the etiology of obesity associated type 2 diabetes mellitus...
