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Evaluation of Murine Host Sex as a Biological Variable in Transplanted Human Intestinal Organoid Development
BackgroundHuman intestinal organoids (HIOs), when transplanted into immunocompromised mice (tHIOs), demonstrate significant growth and maturation....
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Sex differences in the use of mechanical ventilation in a neurointensive care population: a retrospective study
BackgroundIn the general intensive care unit (ICU) women receive invasive mechanical ventilation (IMV) less frequently than men. We investigated...
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A sex-specific genome-wide association study of depression phenotypes in UK Biobank
There are marked sex differences in the prevalence, phenotypic presentation and treatment response for major depression. While genome-wide...
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Multi-parametric non-contrast cardiac magnetic resonance for the differentiation between cardiac amyloidosis and hypertrophic cardiomyopathy
AimTo evaluate the ability of fast strain-encoded (SENC) cardiac magnetic resonance (CMR) derived myocardial strain and native T1 mapping to...
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Influence of diabetes mellitus on the pathological profile of aortic stenosis: a sex-based approach
BackgroundDiabetes mellitus (DM) accelerates the progression of aortic stenosis (AS), but how their underlying molecular mechanisms interact is not...
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Sex differences in long-term kidney fibrosis following neonatal nephron loss during ongoing nephrogenesis
BackgroundClinical studies suggest that female sex plays a protective role in the development and progression of kidney disease. Recent experimental...
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Associations between neighborhood stress and maternal sex steroid hormones in pregnancy
BackgroundNeighborhood stressors (e.g., crime and deprivation) have been associated with adverse pregnancy outcomes including preterm birth and low...
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Exploring specific associations of childhood maltreatment with social cognition in drug-naive first-episode major depressive disorder: a sex-centric approach
Childhood maltreatment (CM) has been linked to social cognition deficits in major depressive disorder (MDD), but little is known about sex-specific...
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Growth differentiation factor 15 (GDF-15) in endocrinology
Human growth differentiation factor 15 (GDF-15) is a widely distributed protein that has shown to play multiple roles in both physiological and...
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Sinonasal mucosal melanoma with smooth muscle differentiation: a potential pathological diagnostic pitfall
BackgroundSinonasal mucosal melanoma (SNMM) is a rare malignant melanoma originating from melanocytes derived from multipotent neural crest cells....
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Spectrum of Genital and Extragenital Anomalies in Malformation Syndromes Associated With 46, XY Disorders of Sex Development: A Single Center Experience
ObjectivesThis study aimed at integrating the clinical and phenotypic characteristics, hormonal profile and genetic diagnosis of children with...
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Heart Failure in the Elderly: the Role of Biological and Sociocultural Aspects Related to Sex
Purpose of ReviewHeart failure (HF) entails poor prognosis, with high morbidity and mortality burden, particularly in elderly patients. Notably,...
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Sex differences in glycolipidic disorders after exposure to maternal hyperglycemia during early development
PurposeThe aim of this review was to summarize sex differences in glycolipid metabolic phenotypes of human and animal models after exposure to...
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Sex-dependent risk factors for PTSD: a prospective structural MRI study
Female individuals are more likely to be diagnosed with PTSD following trauma exposure than males, potentially due, in part, to underlying...
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Sex differences in health-related quality of life and psychological distress among colorectal cancer patients: a 2-year longitudinal study
PurposeWhile sex differences in the incidence and mortality of colorectal cancer (CRC) are well documented, less is known about sex differences in...
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Malignant testicular unclassified sex cord stromal tumor: a case report
BackgroundMost testicular tumors are germ cell tumors; sex cord stromal tumors are infrequent, accounting for only 3–5% of testicular tumors....
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Serum growth differentiation factor-15 (GDF-15) is a biomarker of cardiac manifestations in children with COVID-19
BackgroundCOVID-19 leads to severe overwhelming inflammation in some patients mediated by various cytokines (cytokine storm) that usually leads to...
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Exploratory analysis of new craniometric measures for the investigation of biological sex using open-access statistical and machine-learning tools on a cone-beam computed tomography sample
Investigation of the biological sex of human remains is a crucial aspect of physical anthropology. However, due to varying states of skeletal...
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Latent Class Analysis of Online Platforms for Partner-Seeking and Sexual Behaviors Among Men Who Have Sex with Men from Central Kentucky
Little is known whether engagement in sexual behaviors associated with potential HIV risks differs by subgroups of men who have sex with men (MSM),...
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A 3D atlas of the human developing pancreas to explore progenitor proliferation and differentiation
Aims/hypothesisRodent pancreas development has been described in great detail. On the other hand, there are still gaps in our understanding of the...
