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Lixisenatide in early parkinson’s disease: efficacy, safety, and future directions: a correspondence
Parkinson’s disease (PD) presents as a complex neurodegenerative disorder characterized by motor and non-motor symptoms, resulting from dopaminergic...
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Pharyngeal adaptation to bolus properties in patients with Parkinson’s disease
PurposeDysphagia is common in people with Parkinson’s disease (PD). Yet, literature describing swallow function in PD using high-resolution manometry...
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Serum salusin-α and -β levels in patients with parkinson’s disease
BackgroundThe etiology of Parkinson’s disease (PD) is not well known and there is increasing evidence that oxidative stress also plays an important...
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The Effects of Safinamide in Chinese and Non-Chinese Patients with Parkinson’s Disease
IntroductionEthnicity differences are an important determinant in the clinical manifestation of Parkinson’s disease (PD), but they are not yet widely...
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Sympathetic dysfunction as an early indicator of autonomic involvement in Parkinson’s disease
PurposeThe specific characteristics of autonomic involvement in patients with early Parkinson’s disease (PD) are unclear. This study aimed to...
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Gender differences in non-motor fluctuations in Parkinson’s disease
Non-motor symptoms (NMS) and Non-motor fluctuations (NMF) in Parkinson’s Disease (PD) are common, involving several domains and affecting quality of...
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Impact of autonomic symptoms on the clinical course of Parkinson’s disease
PurposePatients with Parkinson’s disease (PD) exhibit various degrees of autonomic symptoms, which may be associated with Lewy body pathology...
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Research progress in the early diagnosis of Parkinson’s disease
Parkinson’s disease is the second major neurodegenerative disease with increasing incidence and population in the world year by year. The...
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Association of health behaviors with function and health-related quality of life among patients with Parkinson’s disease
BackgroundCurrent evidence on chronic conditions favors promotion of health behaviors as a mean to positively impact health outcomes. In Parkinson’s...
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Association of activities of daily living, mobility and balance ability, and symptoms of Parkinson’s disease with the masses and amounts of intramuscular non-contractile tissue of the trunk and lower extremity muscles in patients with Parkinson’s disease
PurposeWe examined the association of activities of daily living (ADL), mobility and balance ability, and symptoms of Parkinson’s disease (PD) with...
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Axial postural abnormalities and pain in Parkinson’s disease
Axial postural abnormalities and pain are two main determinants of poor quality of life in patients with Parkinson’s disease (PD). Indeed, a detailed...
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Directional versus ring-mode deep brain stimulation for Parkinson’s disease: protocol of a multi-centre double-blind randomised crossover trial
BackgroundThe effectiveness of Deep Brain Stimulation (DBS) therapy for Parkinson’s disease can be limited by side-effects caused by electrical...
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Randomized controlled trial of intermittent hypoxia in Parkinson’s disease: study rationale and protocol
BackgroundParkinson’s disease (PD) is a neurodegenerative disease for which no disease-modifying therapies exist. Preclinical and clinical evidence...
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Anatomical correlates of apathy and impulsivity co-occurrence in early Parkinson’s disease
BackgroundAlthough apathy and impulse control disorders (ICDs) are considered to represent opposite extremes of a continuum of motivated behavior...
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Association between fatigue and MDS-UPDRS in individuals with Parkinson’s disease: cross-sectional study
BackgroundFatigue is significant in the context of Parkinson’s disease (PD), considering that one-third of patients classify it as the most...
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Correlation between the MNCD classification-based staging of Parkinson’s disease and quality of life: a cross-sectional study
Parkinson’s disease (PD) is a highly heterogeneous neurodegenerative disorder with varying clinical subtypes. Recently, a novel classification called...
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Prediction of Parkinson’s disease by transcranial sonography-based deep learning
ObjectivesTranscranial sonography has been used as a valid neuroimaging tool to diagnose Parkinson’s disease (PD). This study aimed to develop a...
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Association between major dietary patterns and Parkinson’s disease risk: a case–control study
BackgroundThere has been emerging attention to investigate the possible role of some dietary factors in the pathogenesis of Parkinson’s disease (PD);...
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Dyskinesia and Pain in Advanced Parkinson’s Disease: Post Hoc Analysis from the Phase 3b, Open-Label, Randomized DYSCOVER Study
IntroductionThe DYSCOVER study was a phase 3b, open-label, randomized trial (NCT02799381) that evaluated levodopa-carbidopa intestinal gel (LCIG)...
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Retinal functional and structural changes in patients with Parkinson’s disease
BackgroundVisual dysfunction have been well reported as one of the non-motor symptoms in Parkinson’s disease (PD). The aim of this study was to...
