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Do we really need cyclophosphamide for lupus nephritis?
A 14-year-old patient presents with hematuria and proteinuria. Clinical evaluation reveals a positive anti-nuclear antibody titer, positive...
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Regulatory T cells in skin regeneration and wound healing
As the body’s integumentary system, the skin is vulnerable to injuries. The subsequent wound healing processes aim to restore dermal and epidermal...
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Homeostasis and dyshomeostasis of the retina
Retinal homeostasis is maintained through a network of the nervous, circulatory, endocrine and immune systems. The integrity of the blood-retinal...
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The role of cancer-derived microRNAs in cancer immune escape
During malignant transformation, accumulated somatic mutations endow cancer cells with increased invasiveness and immunogenicity. Under selective...
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Optimizing aseptic and serum milieu for the isolation of human whole umbilical cord tissue-derived mesenchymal stem cells
BackgroundMesenchymal stem cells (MSCs) have become an attractive tool for tissue engineering and targets in clinical transplantation due to their...
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Baricitinib for the Treatment of Alopecia Areata
Alopecia areata (AA) is a relapsing, chronic, immune-mediated disease characterized by nonscarring, inflammatory hair loss that can affect any...
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Mitophagy genes in ovarian cancer: a comprehensive analysis for improved immunotherapy
BackgroundMitophagy is a process of selectively degrading damaged mitochondria, which has been found to be related to immunity, tumorigenesis, tumor...
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A Podcast Discussion on the Current Treatment Landscape for Renal Cell Carcinoma
During the last 15 years, tremendous efforts have been made in the medical treatment of metastatic renal cell carcinoma (mRCC). Immune-oncological...
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The role of thymic stromal lymphopoietin in cutaneous disorders
Thymic Stromal Lymphopoietin (TSLP) is an important cytokine that invokes early immune responses. TSLP, an IL-7-like cytokine encoded by the TSLP ...
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SARS-CoV-2 infection and human semen: possible modes of contamination and transmission
BackgroundCoronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), has turned into a global...
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Down Syndrome and Autoimmune Disease
Down syndrome is the most common genetic cause of intellectual disability and has previously been associated with a variety of autoimmune disorders...
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Neuro-ophthalmic complications of modern anti-cancer drugs
PurposeTargeted cancer therapies have been responsible for a dramatic shift in treatment strategies for cancer, and the number of drugs, classes, and...
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Qiangjing tablets repair of blood-testis barrier dysfunction in rats via regulating oxidative stress and p38 MAPK pathway
BackgroundThe blood-testis barrier (BTB) is a physical barrier of the testis to prevent various exogenous substrates from entering apical...
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Identification of co-expressed gene networks promoting CD8+ T cell infiltration and having prognostic value in uveal melanoma
Current immunotherapies are unsatisfactory against uveal melanoma (UM); however, elevated CD8 + T cell infiltration level indicates poor prognosis in...
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Autoimmune Inflammatory Eye Disease: Demystifying Clinical Presentations for the Internist
Purpose of ReviewProvide a framework for recognizing key symptoms and clinical findings in patients with autoimmune inflammatory eye disease.
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Antenatal hepatitis B virus sero-prevalence, risk factors, pregnancy outcomes and vertical transmission rate within 24 months after birth in a high HIV prevalence setting
BackgroundDespite the availability of an effective vaccine, chronic hepatitis B virus (HBV) infections remain a major cause of liver cirrhosis and...
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Alopecia Areata: an Update on Etiopathogenesis, Diagnosis, and Management
Alopecia areata (AA) is a common chronic tissue-specific autoimmune disease, resulting in hair loss, that affects up to 2% of the general population....
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Review on Alopecia Areata in the Middle East and Africa: Landscape and Unmet Needs
BackgroundAlopecia areata (AA) is an autoimmune disease characterized by non-scarring hair loss in adults and children. Clinical manifestations range...
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Alopecia areata: a review on diagnosis, immunological etiopathogenesis and treatment options
Patients suffering from alopecia areata (AA) can lose hair in focal regions, the complete scalp, including eyelashes and eyebrows, or even the entire...
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Alopecia Areata: Current Treatments and New Directions
Alopecia areata is an autoimmune hair loss disease that is non-scarring and is characterized by chronic inflammation at the hair follicle level....
