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High levels of LINE-1 transposable elements expressed in Kaposi’s sarcoma-associated herpesvirus-related primary effusion lymphoma
Kaposi’s sarcoma-associated herpesvirus (KSHV, HHV-8) is a gamma herpesvirus associated with several human malignancies. Transposable elements (TEs)...
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Granzyme serine proteases in inflammation and rheumatic diseases
Granzymes (granule-secreted enzymes) are a family of serine proteases that have been viewed as redundant cytotoxic enzymes since their discovery more...
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TCR engineered T cells for solid tumor immunotherapy
T cell immunotherapy remains an attractive approach for cancer immunotherapy. T cell immunotherapy mainly employs chimeric antigen receptor (CAR)-...
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ERVs-TLR3-IRF axis is linked to myelodysplastic syndrome pathogenesis
AbstractToll-like receptors are mutated or overexpressed in up to 50% of patients with myelodysplastic syndrome (MDS). Endogenous retroviruses (ERV)...
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RNA N6-methyladenosine modifications in urological cancers: from mechanism to application
The N 6 ‐methyladenosine (m 6 A) modification is the most common modification of messenger RNAs in eukaryotes and has crucial roles in multiple cancers,...
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Decrease of Membrane B7-H5 on CD14+ Cells in Severe Acute Pancreatitis Is Related to RANSON Scores and APACHE II Scores
BackgroundB7-H5 is an important ligand which is deeply involved in the immune response in various diseases. However, its clinical usefulness as an...
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Common risk alleles for schizophrenia within the major histocompatibility complex predict white matter microstructure
Recent research has highlighted the role of complement genes in shaping the microstructure of the brain during early development, and in contributing...
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Beyond conventional immune-checkpoint inhibition — novel immunotherapies for renal cell carcinoma
The management of advanced-stage renal cell carcinoma (RCC) has been transformed by the development of immune-checkpoint inhibitors (ICIs)....
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G9a controls pluripotent-like identity and tumor-initiating function in human colorectal cancer
Colorectal tumors are hierarchically organized and governed by populations of self-renewing cancer stem cells, representing one of the deadliest...
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DNA hydrolysing IgG catalytic antibodies: an emerging link between psychoses and autoimmunity
It is not uncommon to observe autoimmune comorbidities in a significant subset of patients with psychotic disorders, namely schizophrenia (SCZ) and...
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Augmenting engineered T-cell strategies in solid cancers through epigenetic priming
T-cell receptor (TCR)- and chimeric antigen receptor (CAR)-based adoptive cell transfer (ACT) has shown promising results in hematological...
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COVID-19, Retroelements, and Aging
AbstractThe review presents an analysis of the scientific data on the characteristics of COVID-19 from the perspective of potential interactions...
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„Auf den Krieg vorbereiten, wenn du Frieden willst“ – eine Analyse des polizeilichen Gefahrennarrativs
It is intuitively and scientifically undisputed that the police profession carries an inherent risk of victimization by violence; however, it is...
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Breast cancer immunotherapy: a comprehensive review
Cancer remains a major health problem despite numerous new medical interventions that have been introduced in recent years. One of the major choices...
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Long Non-coding RNA UCA1a Promotes Proliferation via PKM2 in Cervical Cancer
Cervical cancer is a common malignancy that affects women worldwide. The long non-coding RNA (lncRNA) urothelial cancer-associated 1a ( UCA1a ) is...
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Increased activation product of complement 4 protein in plasma of individuals with schizophrenia
Structural variation in the complement 4 gene ( C4 ) confers genetic risk for schizophrenia. The variation includes numbers of the increased C4A copy...
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A potential new mechanism for pregnancy loss: considering the role of LINE-1 retrotransposons in early spontaneous miscarriage
LINE1 retrotransposons are mobile DNA elements that copy and paste themselves into new sites in the genome. To ensure their evolutionary success,...
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Human immunodeficiency virus and multiple sclerosis: a review of the literature
Multiple sclerosis (MS) and human immunodeficiency virus (HIV) infection are frequent and well-studied nosological entities. Yet, comorbidity of MS...
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Interactions between a polygenic risk score for plasma docosahexaenoic fatty acid concentration, eating behaviour, and body composition in children
BackgroundThe relationship between eating behaviour and current body weight has been described. However little is known about the effect of...
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Clinical and Pathological Characteristics and Outcomes of Clear Cell Carcinoma of Ovary: A Tertiary Cancer Centre Data
IntroductionClear cell carcinoma of ovary is a rare disease. Historically, they have been treated in lines of serous ovarian cancer. But available...
